XB-ART-358
Proc Natl Acad Sci U S A
2006 May 30;10322:8540-5. doi: 10.1073/pnas.0600194103.
Show Gene links
Show Anatomy links
Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513.
Wallner M
,
Hanchar HJ
,
Olsen RW
.
???displayArticle.abstract???
???displayArticle.pubmedLink??? 16698930
???displayArticle.pmcLink??? PMC1482527
???displayArticle.link??? Proc Natl Acad Sci U S A
???displayArticle.grants??? [+]
AA 015460 NIAAA NIH HHS , AA 07680 NIAAA NIH HHS , NS 35985 NINDS NIH HHS , F31 AA015460 NIAAA NIH HHS , P01 NS035985 NINDS NIH HHS , R37 AA007680 NIAAA NIH HHS , R01 AA007680 NIAAA NIH HHS
Species referenced: Xenopus laevis
Genes referenced: gabarap
References [+] :
Aguayo,
GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions?
2002, Pubmed
Aguayo, GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions? 2002, Pubmed
Allan, Gamma-aminobutyric acid and alcohol actions: neurochemical studies of long sleep and short sleep mice. 1986, Pubmed
Belelli, The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. 1997, Pubmed , Xenbase
Benson, Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits. 1998, Pubmed
Blednov, A pervasive mechanism for analgesia: activation of GIRK2 channels. 2003, Pubmed
Boileau, The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes. 2002, Pubmed , Xenbase
Bonetti, Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol. 1988, Pubmed
Borghese, The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. 2006, Pubmed , Xenbase
Brickley, Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. 2001, Pubmed
Britton, Is ethanol antagonist Ro15-4513 selective for ethanol? 1988, Pubmed
Brown, Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. 2002, Pubmed
Carta, Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability. 2004, Pubmed
Costa, G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses. 2005, Pubmed
Criswell, A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary. 2005, Pubmed
Dar, Antagonism by intracerebellar Ro15-4513 of acute ethanol-induced motor incoordination in mice. 1995, Pubmed
Dar, Possible role of adenosine in the CNS effects of ethanol. 1983, Pubmed
Davies, Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. 1997, Pubmed
Davies, A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. 2003, Pubmed
Davies, Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. 2003, Pubmed , Xenbase
Farrant, Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. 2005, Pubmed
Foreman, A study of the histamine H2-receptor mediating relaxation of the parenchymal lung strip preparation of the guinea-pig. 1985, Pubmed
Glowa, Ethanol and the GABA receptor complex: studies with the partial inverse benzodiazepine receptor agonist Ro 15-4513. 1988, Pubmed
Hanchar, Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors. 2006, Pubmed
Hanchar, Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. 2005, Pubmed , Xenbase
Hoffman, Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital. 1987, Pubmed
Hu, Interaction between flurazepam and ethanol. 1987, Pubmed
Ikeda, Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys? 2002, Pubmed
June, Ro15-4513 attenuates the consumption of ethanol in deprived rats. 1991, Pubmed
June, Interactions of Ro15-4513, Ro15-1788 (flumazenil) and ethanol on measures of exploration and locomotion in rats. 1994, Pubmed
June, Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil). 1994, Pubmed
Jurd, General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. 2003, Pubmed
Khanna, Rapid tolerance and crosstolerance to motor impairment effects of benzodiazepines, barbiturates, and ethanol. 1998, Pubmed
Kobayashi, Ethanol opens G-protein-activated inwardly rectifying K+ channels. 1999, Pubmed , Xenbase
Kolata, New drug counters alcohol intoxication. 1986, Pubmed
Korpi, Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor. 1993, Pubmed
Laurie, The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. 1992, Pubmed
Liang, Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. 2006, Pubmed
Liljequist, Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes. 1982, Pubmed
Liu, Essential role for smooth muscle BK channels in alcohol-induced cerebrovascular constriction. 2004, Pubmed
Mihalek, GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol. 2001, Pubmed
Mihic, Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. 1997, Pubmed , Xenbase
Ming, Differential modulation of GABA- and NMDA-gated currents by ethanol and isoflurane in cultured rat cerebral cortical neurons. 2001, Pubmed
Nabeshima, Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513. 1988, Pubmed
Nusser, Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. 2002, Pubmed
Nusser, Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. 1998, Pubmed
Nutt, Antagonizing the anticonvulsant effect of ethanol using drugs acting at the benzodiazepine/GABA receptor complex. 1988, Pubmed
Palmer, Antagonism of ethanol effects on cerebellar Purkinje neurons by the benzodiazepine inverse agonists Ro 15-4513 and FG 7142: electrophysiological studies. 1988, Pubmed
Paul, Alcohol-sensitive GABA receptors and alcohol antagonists. 2006, Pubmed
Petry, Ro 15-4513 selectively attenuates ethanol, but not sucrose, reinforced responding in a concurrent access procedure; comparison to other drugs. 1995, Pubmed
Popp, Factors that enhance ethanol inhibition of N-methyl-D-aspartate receptors in cerebellar granule cells. 1999, Pubmed
Rassnick, GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol. 1993, Pubmed
Reynolds, Ethanol modulation of GABA receptor-activated Cl- currents in neurons of the chick, rat and mouse central nervous system. 1992, Pubmed
Saxena, Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms. 1996, Pubmed
Sigel, Mapping of the benzodiazepine recognition site on GABA(A) receptors. 2002, Pubmed
Suzdak, Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. 1986, Pubmed
Suzdak, A selective imidazobenzodiazepine antagonist of ethanol in the rat. 1986, Pubmed
Suzdak, Response: is ethanol antagonist rol5-4513 selective for ethanol? 1988, Pubmed
Suzdak, Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat. 1988, Pubmed
Syapin, Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia. 1987, Pubmed
Syapin, Interactions between benzodiazepine antagonists, inverse agonists, and acute behavioral effects of ethanol in mice. 1990, Pubmed
Thompson, Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics. 2002, Pubmed , Xenbase
Wafford, A novel allosteric modulatory site on the GABAA receptor beta subunit. 1994, Pubmed , Xenbase
Wallner, Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans. 2003, Pubmed , Xenbase
Wei, Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons. 2004, Pubmed
Wei, Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. 2003, Pubmed
White, Differential effects of ethanol on motor coordination in adolescent and adult rats. 2002, Pubmed