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XB-ART-35865
FEBS Lett 2007 May 29;58113:2478-84. doi: 10.1016/j.febslet.2007.04.065.
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Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels.

Kozminsky-Atias A , Somech E , Zilberberg N .


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We have purified BoiTx1, the first toxin from the venom of the Israeli scorpion, Buthus occitanus israelis, and studied its activity and genomic organization. BoiTx1 is a 37 amino acid-long peptide contained six conserved cysteines, and is classified as an alpha-KTx3.10 toxin. The pharmacological effects of BoiTx1 were studied on various cloned K(+) channels expressed in Xenopus laevis oocytes. BoiTx1 inhibited currents through Drosophila Shaker channels with an IC(50) value of 3.5+/-0.5nM, yet had much lesser effect on its mammalian orthologs. Thus, BoiTx1 is the first member of the alpha-KTx3 family that preferentially affects insect potassium channels.

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