XB-ART-36530
Sci STKE
2007 Sep 25;2007405:pe54. doi: 10.1126/stke.4052007pe54.
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The spark of life: electricity and regeneration.
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A recent paper shows that a proton pump, the vacuolar-type adenosine triphosphatase (V-ATPase), is necessary for Xenopus tadpole tail regeneration. The V-ATPase is synthesized in distal cells of the regeneration bud as an early response to amputation, and its role in regeneration is specifically to pump H+ out of cells. Although the downstream effects of proton movement are not known, they may be mediated through changes in membrane potential. This work could reopen a consideration of the role of electric fields in regeneration, an issue that has caused much controversy in the past.
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