Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Cell
2007 Aug 24;1304:730-41. doi: 10.1016/j.cell.2007.06.045.
Show Gene links
Show Anatomy links
Intrinsic circadian clock of the Mammalian retina: importance for retinal processing of visual information.
Storch KF
,
Paz C
,
Signorovitch J
,
Raviola E
,
Pawlyk B
,
Li T
,
Weitz CJ
.
???displayArticle.abstract???
Circadian clocks are widely distributed in mammalian tissues, but little is known about the physiological functions of clocks outside the suprachiasmatic nucleus of the brain. The retina has an intrinsic circadian clock, but its importance for vision is unknown. Here we show that mice lacking Bmal1, a gene required for clock function, had abnormal retinal transcriptional responses to light and defective inner retinal electrical responses to light, but normal photoreceptor responses to light and retinas that appeared structurally normal by light and electron microscopy. We generated mice with a retina-specific genetic deletion of Bmal1, and they had defects of retinal visual physiology essentially identical to those of mice lacking Bmal1 in all tissues and lacked a circadian rhythm of inner retinal electrical responses to light. Our findings indicate that the intrinsic circadian clock of the retina regulates retinal visual processing in vivo.
Abe,
Circadian rhythms in isolated brain regions.
2002, Pubmed
Abe,
Circadian rhythms in isolated brain regions.
2002,
Pubmed
Akhtar,
Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus.
2002,
Pubmed
Bailey,
Transcriptional profiling of circadian patterns of mRNA expression in the chick retina.
2004,
Pubmed
Balsalobre,
A serum shock induces circadian gene expression in mammalian tissue culture cells.
1998,
Pubmed
Bardeesy,
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.
2002,
Pubmed
Barnard,
Melanopsin regulates visual processing in the mouse retina.
2006,
Pubmed
Besharse,
Circadian clock in Xenopus eye controlling retinal serotonin N-acetyltransferase.
,
Pubmed
,
Xenbase
Bunger,
Mop3 is an essential component of the master circadian pacemaker in mammals.
2000,
Pubmed
Cahill,
Circadian clock functions localized in xenopus retinal photoreceptors.
1993,
Pubmed
,
Xenbase
Ceriani,
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior.
2002,
Pubmed
Crosio,
Light induces chromatin modification in cells of the mammalian circadian clock.
2000,
Pubmed
Damiola,
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.
2000,
Pubmed
Doyle,
Circadian rhythms of dopamine in mouse retina: the role of melatonin.
2002,
Pubmed
Duffield,
Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells.
2002,
Pubmed
Durgan,
The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids.
2006,
Pubmed
Farley,
Widespread recombinase expression using FLPeR (flipper) mice.
2000,
Pubmed
Gekakis,
Role of the CLOCK protein in the mammalian circadian mechanism.
1998,
Pubmed
Goto,
Melatonin content of the pineal gland in different mouse strains.
1989,
Pubmed
Gustincich,
Control of dopamine release in the retina: a transgenic approach to neural networks.
1997,
Pubmed
Gustincich,
Gene discovery in genetically labeled single dopaminergic neurons of the retina.
2004,
Pubmed
Hattar,
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.
2003,
Pubmed
Hayasaka,
In vivo disruption of Xenopus CLOCK in the retinal photoreceptor cells abolishes circadian melatonin rhythmicity without affecting its production levels.
2002,
Pubmed
,
Xenbase
Humphries,
Circadian dependency of nocturnal immediate-early protein induction in rat retina.
2004,
Pubmed
Ko,
Molecular components of the mammalian circadian clock.
2006,
Pubmed
Kondratov,
Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation.
2006,
Pubmed
Kraves,
A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity.
2006,
Pubmed
LaVail,
Studies on the hormonal control of circadian outer segment disc shedding in the rat retina.
1978,
Pubmed
Li,
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application.
2001,
Pubmed
Lin,
Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.
2002,
Pubmed
Liu,
A highly efficient recombineering-based method for generating conditional knockout mutations.
2003,
Pubmed
Lu,
The mammalian retinal degeneration B2 gene is not required for photoreceptor function and survival.
2001,
Pubmed
Manglapus,
Circadian rhythms of rod-cone dominance in the Japanese quail retina.
1998,
Pubmed
Masana,
Light-induced c-fos mRNA expression in the suprachiasmatic nucleus and the retina of C3H/HeN mice.
1996,
Pubmed
McDearmon,
Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice.
2006,
Pubmed
McGoogan,
Circadian regulation of chick electroretinogram: effects of pinealectomy and exogenous melatonin.
1999,
Pubmed
Miranda-Anaya,
Circadian rhythm of iguana electroretinogram: the role of dopamine and melatonin.
2002,
Pubmed
Nir,
Dysfunctional light-evoked regulation of cAMP in photoreceptors and abnormal retinal adaptation in mice lacking dopamine D4 receptors.
2002,
Pubmed
Ouyang,
Resonating circadian clocks enhance fitness in cyanobacteria.
1998,
Pubmed
Panda,
Coordinated transcription of key pathways in the mouse by the circadian clock.
2002,
Pubmed
Panda,
It's all in the timing: many clocks, many outputs.
2004,
Pubmed
Pierce,
Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture.
1993,
Pubmed
Ripperger,
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP.
2000,
Pubmed
Rowan,
Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter.
2004,
Pubmed
Ruan,
Circadian organization of the mammalian retina.
2006,
Pubmed
Schwenk,
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.
1995,
Pubmed
Soriano,
Generalized lacZ expression with the ROSA26 Cre reporter strain.
1999,
Pubmed
Storch,
Extensive and divergent circadian gene expression in liver and heart.
2002,
Pubmed
,
Xenbase
Tanoue,
Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila.
2004,
Pubmed
Tosini,
Circadian rhythms in cultured mammalian retina.
1996,
Pubmed
Wijnen,
Control of daily transcript oscillations in Drosophila by light and the circadian clock.
2006,
Pubmed
Witkovsky,
Cellular location and circadian rhythm of expression of the biological clock gene Period 1 in the mouse retina.
2003,
Pubmed
Yamazaki,
Resetting central and peripheral circadian oscillators in transgenic rats.
2000,
Pubmed
