XB-ART-36638
Pflugers Arch
2006 Dec 01;4533:333-51. doi: 10.1007/s00424-006-0131-0.
Show Gene links
Show Anatomy links
Twenty odd years of stretch-sensitive channels.
Hamill OP
.
???displayArticle.abstract???
After formation of the giga-seal, the membrane patch can be stimulated by hydrostatic or osmotic pressure gradients applied across the patch. This feature led to the discovery of stretch-sensitive or mechanosensitive (MS) channels, which are now known to be ubiquitously expressed in cells representative of all the living kingdoms. In addition to mechanosensation, MS channels have been implicated in many basic cell functions, including regulation of cell volume, shape, and motility. The successful cloning, overexpression, and crystallization of bacterial MS channel proteins combined with patch clamp and modeling studies have provided atomic insight into the working of these nanomachines. In particular, studies of MS channels have revealed new understanding of how the lipid bilayer modulates membrane protein function. Three major membrane protein families, transient receptor potential, 2 pore domain K(+), and the epithelial Na(+) channels, have been shown to form MS channels in animal cells, and their polymodal activation embrace fields far beyond mechanosensitivity. The discovery of new drugs highly selective for MS channels ("mechanopharmaceutics") and the demonstration of MS channel involvement in several major human diseases ("mechanochannelopathies") provide added motivation for devising new techniques and approaches for studying MS channels.
???displayArticle.pubmedLink??? 17021800
???displayArticle.link??? Pflugers Arch
Species referenced: Xenopus laevis
GO keywords: potassium ion transport [+]
???displayArticle.disOnts??? Duchenne muscular dystrophy [+]
???displayArticle.omims??? POLYCYSTIC KIDNEY DISEASE 1 WITH OR WITHOUT POLYCYSTIC LIVER DISEASE; PKD1 [+]
MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD
GLAUCOMA, NORMAL TENSION, SUSCEPTIBILITY TO
GLIOMA SUSCEPTIBILITY 3; GLM3
References [+] :
Ajouz,
Contributions of the different extramembranous domains of the mechanosensitive ion channel MscL to its response to membrane tension.
2000, Pubmed
Ajouz, Contributions of the different extramembranous domains of the mechanosensitive ion channel MscL to its response to membrane tension. 2000, Pubmed
Akitake, The "dashpot" mechanism of stretch-dependent gating in MscS. 2005, Pubmed
Allen, Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes. 2005, Pubmed
Ashcroft, From molecule to malady. 2006, Pubmed
Assad, Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells. 1989, Pubmed
Bang, TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family. 2000, Pubmed
Bass, Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. 2002, Pubmed
Besch, High-speed pressure clamp. 2002, Pubmed
Bielfeld-Ackermann, Maitotoxin (MTX) activates a nonselective cation channel in Xenopus laevis oocytes. 1998, Pubmed , Xenbase
Blount, Molecular mechanisms of mechanosensation: big lessons from small cells. 2003, Pubmed
Bowman, Mechanotransducing ion channels in C6 glioma cells. 1996, Pubmed
Brereton, Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. 2001, Pubmed
Bryan-Sisneros, Electrophysiological, mechanosensitive responses of Xenopus laevis oocytes to direct, isotonic increase in intracellular volume. 2003, Pubmed , Xenbase
Buckler, The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection. 2005, Pubmed
Caldwell, Using gadolinium to identify stretch-activated channels: technical considerations. 1998, Pubmed
Cantiello, A tale of two tails: ciliary mechanotransduction in ADPKD. 2003, Pubmed
Casado, Opposite modulation of NMDA receptors by lysophospholipids and arachidonic acid: common features with mechanosensitivity. 1998, Pubmed
Cemerikic, Substrate activation of mechanosensitive, whole cell currents in renal proximal tubule. 1993, Pubmed
Chang, Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. 1998, Pubmed
Chapleau, Structural versus functional modulation of the arterial baroreflex. 1995, Pubmed
Chemin, A phospholipid sensor controls mechanogating of the K+ channel TREK-1. 2005, Pubmed
Chen, The relationship between cAMP, Ca(2)+, and transport of CFTR to the plasma membrane. 2001, Pubmed
Chen, Integrins and modulation of transmitter release from motor nerve terminals by stretch. 1995, Pubmed
Christensen, Mediation of cell volume regulation by Ca2+ influx through stretch-activated channels. , Pubmed
Clapham, TRP channels as cellular sensors. 2003, Pubmed
Dai, Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers. 1995, Pubmed
Dai, Membrane tether formation from blebbing cells. 1999, Pubmed
Dai, The secretion-coupled endocytosis correlates with membrane tension changes in RBL 2H3 cells. 1997, Pubmed
Dai, Membrane tension in swelling and shrinking molluscan neurons. 1998, Pubmed
Discher, Molecular maps of red cell deformation: hidden elasticity and in situ connectivity. 1994, Pubmed
Discher, Kinematics of red cell aspiration by fluorescence-imaged microdeformation. 1996, Pubmed
Drummond, Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor. 2004, Pubmed
Dunina-Barkovskaya, Gadolinium effects on gigaseal formation and the adhesive properties of a fungal amoeboid cell, the slime mutant of Neurospora crassa. 2004, Pubmed
Dutta, Identification and characterization of stretch-activated ion channels in pollen protoplasts. 2004, Pubmed
Erickson, Microvilli and blebs as sources of reserve surface membrane during cell spreading. 1976, Pubmed
Ermakov, Dipole potentials indicate restructuring of the membrane interface induced by gadolinium and beryllium ions. 2001, Pubmed
Ernstrom, Genetics of sensory mechanotransduction. 2002, Pubmed
Escobar, Maitotoxin, a cationic channel activator. 1998, Pubmed
Fink, A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. 1998, Pubmed , Xenbase
Fink, Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. 1996, Pubmed , Xenbase
Fong, Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin. 1990, Pubmed
Franco, Calcium entry through stretch-inactivated ion channels in mdx myotubes. 1990, Pubmed
Franco-Obregón, Changes in mechanosensitive channel gating following mechanical stimulation in skeletal muscle myotubes from the mdx mouse. 2002, Pubmed , Xenbase
Gil, Two-dimensional kinetic analysis suggests nonsequential gating of mechanosensitive channels in Xenopus oocytes. 2001, Pubmed , Xenbase
Goodman, Transducing touch in Caenorhabditis elegans. 2003, Pubmed
Gottlieb, Mechanosensitive ion channels as drug targets. 2004, Pubmed
Gottlieb, Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom. 2007, Pubmed
Guharay, Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. 1984, Pubmed
Guharay, Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH. 1985, Pubmed
Hamill, The pharmacology of mechanogated membrane ion channels. 1996, Pubmed
Hamill, Molecular basis of mechanotransduction in living cells. 2001, Pubmed , Xenbase
Hamill, Amiloride: a molecular probe for mechanosensitive channels. 1992, Pubmed
Hamill, Mechanogated channels in Xenopus oocytes: different gating modes enable a channel to switch from a phasic to a tonic mechanotransducer. 1997, Pubmed , Xenbase
Hamill, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. 1981, Pubmed
Hamill, Rapid adaptation of single mechanosensitive channels in Xenopus oocytes. 1992, Pubmed , Xenbase
Hamill, A supramolecular complex underlying touch sensitivity. 1996, Pubmed
Hamill, The cloning of a mechano-gated membrane ion channel. 1994, Pubmed
Hamill, Induced membrane hypo/hyper-mechanosensitivity: a limitation of patch-clamp recording. 1997, Pubmed
Häse, Purification and functional reconstitution of the recombinant large mechanosensitive ion channel (MscL) of Escherichia coli. 1995, Pubmed
Honoré, Desensitization of mechano-gated K2P channels. 2006, Pubmed
Honoré, An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1. 2002, Pubmed
Hörber, A look at membrane patches with a scanning force microscope. 1995, Pubmed , Xenbase
Howard, Mechanoelectrical transduction by hair cells. 1988, Pubmed
Howard, Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. 2004, Pubmed
Ingber, Mechanobiology and diseases of mechanotransduction. 2003, Pubmed
Inoue, The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. 2001, Pubmed
Ismailov, Mechanosensitivity of an epithelial Na+ channel in planar lipid bilayers: release from Ca2+ block. 1997, Pubmed
Jacques-Fricke, Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. 2006, Pubmed , Xenbase
Jung, Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. 2003, Pubmed
Kalapesi, Stretch-activated channels: a mini-review. Are stretch-activated channels an ocular barometer? 2005, Pubmed
Kim, A mechanosensitive K+ channel in heart cells. Activation by arachidonic acid. 1992, Pubmed
Kleyman, Amiloride and its analogs as tools in the study of ion transport. 1988, Pubmed
Kloda, Mechanosensitive channel of Thermoplasma, the cell wall-less archaea: cloning and molecular characterization. 2001, Pubmed
Knutton, Microvilli and cell swelling. 1976, Pubmed
Köhler, Increased mechanosensitive currents in aortic endothelial cells from genetically hypertensive rats. 1999, Pubmed
Konoki, Maitotoxin-induced calcium influx in erythrocyte ghosts and rat glioma C6 cells, and blockade by gangliosides and other membrane lipids. 1999, Pubmed
Koprowski, Voltage-independent adaptation of mechanosensitive channels in Escherichia coli protoplasts. 1998, Pubmed
Koprowski, C termini of the Escherichia coli mechanosensitive ion channel (MscS) move apart upon the channel opening. 2003, Pubmed
Kung, A possible unifying principle for mechanosensation. 2005, Pubmed
Lane, Ionic effects on amiloride block of the mechanosensitive channel in Xenopus oocytes. 1993, Pubmed , Xenbase
Lane, Amiloride block of the mechanosensitive cation channel in Xenopus oocytes. 1991, Pubmed , Xenbase
Lane, Structure-activity relations of amiloride and its analogues in blocking the mechanosensitive channel in Xenopus oocytes. 1992, Pubmed , Xenbase
Lee, Regulation of cell movement is mediated by stretch-activated calcium channels. 1999, Pubmed
Lesage, TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. 1996, Pubmed , Xenbase
Levina, Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. 1999, Pubmed
Markin, Thermodynamics of mechanosensitivity. 2004, Pubmed
Maroto, TRPC1 forms the stretch-activated cation channel in vertebrate cells. 2005, Pubmed , Xenbase
Maroto, Brefeldin A block of integrin-dependent mechanosensitive ATP release from Xenopus oocytes reveals a novel mechanism of mechanotransduction. 2001, Pubmed , Xenbase
Martinac, Mechanosensitive ion channels: molecules of mechanotransduction. 2004, Pubmed
Martinac, Pressure-sensitive ion channel in Escherichia coli. 1987, Pubmed
Martinac, Evolutionary origins of mechanosensitive ion channels. 2003, Pubmed
Martinac, Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness. 2002, Pubmed
Martinac, Mechanosensitive ion channels of E. coli activated by amphipaths. 1990, Pubmed
Mayer, Release of cell fragments by invading melanoma cells. 2004, Pubmed
McBride, Pressure-clamp technique for measurement of the relaxation kinetics of mechanosensitive channels. 1993, Pubmed
McBride, Pressure-clamp: a method for rapid step perturbation of mechanosensitive channels. 1992, Pubmed , Xenbase
McBride, Simplified fast pressure-clamp technique for studying mechanically gated channels. 1999, Pubmed
McNeil, Coping with the inevitable: how cells repair a torn surface membrane. 2001, Pubmed
McNeil, An emergency response team for membrane repair. 2005, Pubmed
McNeil, Plasma membrane disruption: repair, prevention, adaptation. 2003, Pubmed
Moe, Assessment of potential stimuli for mechano-dependent gating of MscL: effects of pressure, tension, and lipid headgroups. 2005, Pubmed
Morris, Stretch-inactivated ion channels coexist with stretch-activated ion channels. 1989, Pubmed
Morris, Failure to elicit neuronal macroscopic mechanosensitive currents anticipated by single-channel studies. 1991, Pubmed
Morris, Mechanosensitive ion channels. 1990, Pubmed
Morris, Cell surface area regulation and membrane tension. 2001, Pubmed
Nichol, Tensile strength and dilatational elasticity of giant sarcolemmal vesicles shed from rabbit muscle. 1996, Pubmed
O'Hagan, The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. 2005, Pubmed
Opsahl, Transduction of membrane tension by the ion channel alamethicin. 1994, Pubmed
Opsahl, Lipid-glass adhesion in giga-sealed patch-clamped membranes. 1994, Pubmed
Ostrow, Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiology. 2005, Pubmed
Palmer, Voltage-dependent block by amiloride and other monovalent cations of apical Na channels in the toad urinary bladder. 1984, Pubmed
Paoletti, Mechanosensitivity of NMDA receptors in cultured mouse central neurons. 1994, Pubmed
Patel, A mammalian two pore domain mechano-gated S-like K+ channel. 1998, Pubmed
Patel, Lipid and mechano-gated 2P domain K(+) channels. 2001, Pubmed
Patel, Properties and modulation of mammalian 2P domain K+ channels. 2001, Pubmed
Patel, The 2P-domain K+ channels: role in apoptosis and tumorigenesis. 2004, Pubmed
Patel, Inhalational anesthetics activate two-pore-domain background K+ channels. 1999, Pubmed
Perozo, Gating prokaryotic mechanosensitive channels. 2006, Pubmed
Perozo, Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. 2002, Pubmed
Perozo, Structure and mechanism in prokaryotic mechanosensitive channels. 2003, Pubmed
Prager, Genetic determinants: is there an "atherosclerosis gene"? 2004, Pubmed
Qi, Activation of a mechanosensitive BK channel by membrane stress created with amphipaths. 2005, Pubmed
Ramsey, An introduction to TRP channels. 2006, Pubmed
Rao, TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding. 2006, Pubmed
Raucher, Characteristics of a membrane reservoir buffering membrane tension. 1999, Pubmed
Rees, Crystallographic analyses of ion channels: lessons and challenges. 2000, Pubmed
Reifarth, Stretch-independent activation of the mechanosensitive cation channel in oocytes of Xenopus laevis. 1999, Pubmed , Xenbase
Ruknudin, The ultrastructure of patch-clamped membranes: a study using high voltage electron microscopy. 1991, Pubmed , Xenbase
Rüsch, Block by amiloride and its derivatives of mechano-electrical transduction in outer hair cells of mouse cochlear cultures. 1994, Pubmed , Xenbase
Sachs, Mechanosensitive ion channels in nonspecialized cells. 1998, Pubmed
Sachs, Gated, ion-selective channels observed with patch pipettes in the absence of membranes: novel properties of a gigaseal. 1993, Pubmed
Sachs, Mechanical transduction in biological systems. 1988, Pubmed
Sackin, A stretch-activated K+ channel sensitive to cell volume. 1989, Pubmed
Sackin, Mechanosensitive channels. 1995, Pubmed
Sheetz, Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics. 2006, Pubmed
Sheetz, Modulation of membrane dynamics and cell motility by membrane tension. 1996, Pubmed
Sigurdson, Stretch-activated ion channels in growth cones of snail neurons. 1989, Pubmed
Small, Delayed activation of single mechanosensitive channels in Lymnaea neurons. 1994, Pubmed , Xenbase
Sokabe, The structure and dynamics of patch-clamped membranes: a study using differential interference contrast light microscopy. 1990, Pubmed
Sokabe, Mechanics of patch clamped and intact cell-membranes in relation to SA channel activation. 1993, Pubmed
Sokabe, Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation. 1991, Pubmed
Suchyna, Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. 2000, Pubmed
Suchyna, Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real time. 2004, Pubmed
Suchyna, Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. 2004, Pubmed
Sukharev, Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL. 1999, Pubmed
Sukharev, Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes. 2002, Pubmed
Sukharev, A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. 1994, Pubmed
Sukharev, Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution. 1993, Pubmed
Tanaka, La(3+) and Gd(3+) induce shape change of giant unilamellar vesicles of phosphatidylcholine. 2002, Pubmed
Tang, Characterization of a functionally expressed stretch-activated BKca channel cloned from chick ventricular myocytes. 2003, Pubmed
Togo, A decrease in membrane tension precedes successful cell-membrane repair. 2000, Pubmed
Tousova, Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites. 2005, Pubmed
Trebak, Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition. 2002, Pubmed
Vandebrouck, Involvement of TRPC in the abnormal calcium influx observed in dystrophic (mdx) mouse skeletal muscle fibers. 2002, Pubmed
Vandorpe, Stretch activation of the Aplysia S-channel. 1992, Pubmed
Vanoye, Stretch-activated single K+ channels account for whole-cell currents elicited by swelling. 1999, Pubmed
Verkhovsky, Self-polarization and directional motility of cytoplasm. 1999, Pubmed
Voets, Sensing with TRP channels. 2005, Pubmed
Vogel, Local force and geometry sensing regulate cell functions. 2006, Pubmed
Wan, Activation of mechanosensitive currents in traumatized membrane. 1999, Pubmed
Weber, Maitotoxin induces insertion of different ion channels into the Xenopus oocyte plasma membrane via Ca(2+)-stimulated exocytosis. 2000, Pubmed , Xenbase
Welsh, Transient receptor potential channels regulate myogenic tone of resistance arteries. 2002, Pubmed
Wilkinson, Effects of mechano-gated cation channel blockers on Xenopus oocyte growth and development. 1998, Pubmed , Xenbase
Wu, Mg2+ block and inward rectification of mechanosensitive channels in Xenopus oocytes. 1998, Pubmed , Xenbase
Yang, Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. 1989, Pubmed , Xenbase
Yang, Characterization of stretch-activated ion channels in Xenopus oocytes. 1990, Pubmed , Xenbase
Yeung, Stretch-activated channels in stretch-induced muscle damage: role in muscular dystrophy. 2004, Pubmed
Zampighi, A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes. 1995, Pubmed , Xenbase
Zhang, On the discrepancy between whole-cell and membrane patch mechanosensitivity in Xenopus oocytes. 2000, Pubmed , Xenbase
Zhang, The ion selectivity of a membrane conductance inactivated by extracellular calcium in Xenopus oocytes. 1998, Pubmed , Xenbase
Zhang, Calcium-, voltage- and osmotic stress-sensitive currents in Xenopus oocytes and their relationship to single mechanically gated channels. 2000, Pubmed , Xenbase
Zhang, Mechanically gated channel activity in cytoskeleton-deficient plasma membrane blebs and vesicles from Xenopus oocytes. 2000, Pubmed , Xenbase