Methods Mol Biol 2008 Jan 01;468:145-56. doi: 10.1007/978-1-59745-249-6_11.

Image analysis of calcium release dynamics.

???displayArticle.abstract???
Many aspects of animal development are dependent on the dynamic release of calcium (Ca2+) ions. Although Ca2+ release within a cell is tightly controlled, how the release dynamics result in a specific biological output in embryonic development is less clear. The integration of pharmacological and molecular-genetic studies with in vivo imaging in zebrafish and Xenopus has linked endogenous Ca2+ release to the Wnt signaling network. Our data suggests that distinct Ca2+ release dynamics lead to antagonism of the developmentally important Wnt/beta-catenin pathway while sustained Ca2+ release modulates polarized cell movements.

???displayArticle.pubmedLink??? 19099252
???displayArticle.link??? Methods Mol Biol
???displayArticle.grants??? [+]