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The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
Chen H
,
Kronengold J
,
Yan Y
,
Gazula VR
,
Brown MR
,
Ma L
,
Ferreira G
,
Yang Y
,
Bhattacharjee A
,
Sigworth FJ
,
Salkoff L
,
Kaczmarek LK
.
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Potassium channels activated by intracellular Na(+) ions (K(Na)) play several distinct roles in regulating the firing patterns of neurons, and, at the single channel level, their properties are quite diverse. Two known genes, Slick and Slack, encode K(Na) channels. We have now found that Slick and Slack subunits coassemble to form heteromeric channels that differ from the homomers in their unitary conductance, kinetic behavior, subcellular localization, and response to activation of protein kinase C. Heteromer formation requires the N-terminal domain of Slack-B, one of the alternative splice variants of the Slack channel. This cytoplasmic N-terminal domain of Slack-B also facilitates the localization of heteromeric K(Na) channels to the plasma membrane. Immunocytochemical studies indicate that Slick and Slack-B subunits are coexpressed in many central neurons. Our findings provide a molecular explanation for some of the diversity in reported properties of neuronal K(Na) channels.
Bader,
Sodium-activated potassium current in cultured avian neurones.
, Pubmed
Bader,
Sodium-activated potassium current in cultured avian neurones.
,
Pubmed
Bähring,
Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.
2001,
Pubmed
Bhattacharjee,
Localization of the Na+-activated K+ channel Slick in the rat central nervous system.
2005,
Pubmed
Bhattacharjee,
Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
2003,
Pubmed
,
Xenbase
Bhattacharjee,
Localization of the Slack potassium channel in the rat central nervous system.
2002,
Pubmed
Bhattacharjee,
For K+ channels, Na+ is the new Ca2+.
2005,
Pubmed
Bischoff,
Na+-activated K+ channels in small dorsal root ganglion neurones of rat.
1998,
Pubmed
Brelidze,
A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification.
2003,
Pubmed
,
Xenbase
Brown,
Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.
2008,
Pubmed
,
Xenbase
Callsen,
Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected].
2005,
Pubmed
Cooper,
M-channels: neurological diseases, neuromodulation, and drug development.
2003,
Pubmed
Dryer,
Molecular identification of the Na+-activated K+ channel.
2003,
Pubmed
Dryer,
A Na+-activated K+ current in cultured brain stem neurones from chicks.
1989,
Pubmed
Egan,
Properties and rundown of sodium-activated potassium channels in rat olfactory bulb neurons.
1992,
Pubmed
Egan,
Na(+)-activated K+ channels are widely distributed in rat CNS and in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Gulbis,
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
2000,
Pubmed
,
Xenbase
Haimann,
Sodium-activated potassium current in sensory neurons: a comparison of cell-attached and cell-free single-channel activities.
1992,
Pubmed
Hess,
Characterization of Na+-activated K+ currents in larval lamprey spinal cord neurons.
2007,
Pubmed
Hofherr,
Selective Golgi export of Kir2.1 controls the stoichiometry of functional Kir2.x channel heteromers.
2005,
Pubmed
Joiner,
Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.
1998,
Pubmed
Kameyama,
Intracellular Na+ activates a K+ channel in mammalian cardiac cells.
,
Pubmed
Kim,
Sodium-activated potassium current in guinea pig gastric myocytes.
2007,
Pubmed
Koh,
Na(+)-activated K+ channels localized in the nodal region of myelinated axons of Xenopus.
1994,
Pubmed
,
Xenbase
Mao,
Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C.
2004,
Pubmed
,
Xenbase
Nimigean,
Electrostatic tuning of ion conductance in potassium channels.
2003,
Pubmed
,
Xenbase
Niu,
Potassium inhibition of sodium-activated potassium (K(Na)) channels in guinea-pig ventricular myocytes.
2000,
Pubmed
Paulais,
A Na+- and Cl- -activated K+ channel in the thick ascending limb of mouse kidney.
2006,
Pubmed
Pessia,
Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels.
1996,
Pubmed
,
Xenbase
Phartiyal,
Endoplasmic reticulum retention and rescue by heteromeric assembly regulate human ERG 1a/1b surface channel composition.
2008,
Pubmed
,
Xenbase
Rajan,
Sumoylation silences the plasma membrane leak K+ channel K2P1.
2005,
Pubmed
,
Xenbase
Rodrigo,
A sodium-activated potassium current in intact ventricular myocytes isolated from the guinea-pig heart.
1990,
Pubmed
Safronov,
Properties and functions of Na(+)-activated K+ channels in the soma of rat motoneurones.
1996,
Pubmed
Santi,
Opposite regulation of Slick and Slack K+ channels by neuromodulators.
2006,
Pubmed
,
Xenbase
Schwake,
Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.
2000,
Pubmed
,
Xenbase
Tucker,
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
1997,
Pubmed
,
Xenbase
Wang,
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
1998,
Pubmed
,
Xenbase
Wang,
Conductance properties of the Na(+)-activated K+ channel in guinea-pig ventricular cells.
1991,
Pubmed
Wang,
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits.
2007,
Pubmed
,
Xenbase
Yang,
Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.
2007,
Pubmed
Yuan,
The sodium-activated potassium channel is encoded by a member of the Slo gene family.
2003,
Pubmed
,
Xenbase
Zerangue,
A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.
1999,
Pubmed
,
Xenbase
Zerangue,
An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.
2000,
Pubmed
,
Xenbase
Zhang,
Functional evidence for Na+-activated K+ channels in circular smooth muscle of the opossum lower esophageal sphincter.
2007,
Pubmed
Zheng,
Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels.
1998,
Pubmed
,
Xenbase
Zhou,
Developmental regulation of a Na(+)-activated fast outward K+ current in rat myoblasts.
2004,
Pubmed
