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XB-ART-4085
Mol Cell 2004 Jan 16;131:2-3. doi: 10.1016/s1097-2765(03)00530-6.
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Destruction with a box: substrate recognition by the anaphase-promoting complex.

Zachariae W .


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Destruction boxes mark cyclin B and other proteins degraded in mitosis for ubiquitination by the anaphase-promoting complex (APC/C). In a paper in this issue of Molecular Cell, Yamano et al. show that destruction boxes directly bind to the APC/C in a cell cycle-regulated manner. Interestingly, this interaction does not require APC/C activators of the Cdc20 family, which were thought to be essential for recruiting substrates to the APC/C.

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Species referenced: Xenopus
Genes referenced: cdc20 tbx2

References :
Yamano, Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts. 2004, Pubmed, Xenbase