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A full-length of complementary deoxyribonucleic acid (Tscdc42) encoding a putative Rho-family small GTPase gene cdc42 was isolated from Trichinella spiralis, an economically important parasitic nematode of zoonosis. The uninterrupted open reading frame of TsCDC42 encodes a predicted protein of 147 amino acids and containing a highly conserved domain of CDC42. Comparison with selected sequences from the free-living nematode Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Danio rerio, Mus musculus, and human showed that Tscdc42 is highly conserved. The highest identity of TsCDC42 with CDC42 from Drosophila is 67%, the similarity is up to 73%, the identity of TsCDC42 with the CDC42 homologue of C. elegans is 62%, and the similarity is up to 71%. Phylogenetic analysis of the amino acid sequence data, using the neighbor-joining and maximum parsimony methods, revealed that TsCDC42 is closely related to the molecule inferred from the cdc-42 gene of C. elegans. The transcript of TsCDC42 was analyzed during different stages of the worm.
Aceto,
Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans.
2006, Pubmed
Aceto,
Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans.
2006,
Pubmed
Atwood,
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.
2007,
Pubmed
Azim,
Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor.
2000,
Pubmed
Balklava,
Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic.
2007,
Pubmed
Cappello,
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
2006,
Pubmed
Caron,
Rac and roll over the corpses.
2000,
Pubmed
Cowan,
Acto-myosin reorganization and PAR polarity in C. elegans.
2007,
Pubmed
Gao,
Assembly of epithelial tight junctions is negatively regulated by Par6.
2002,
Pubmed
Hu,
Adaptation of multilocus sequencing for studying variation within a major clone: evolutionary relationships of Salmonella enterica serovar Typhimurium.
2006,
Pubmed
Hurd,
Pars and polarity: taking control of Rac.
2005,
Pubmed
Johansson,
The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
2000,
Pubmed
Kay,
CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans.
2001,
Pubmed
Leclair,
A preliminary investigation on the infectivity of Trichinella larvae in traditional preparations of walrus meat.
2004,
Pubmed
Malakauskas,
Molecular epidemiology of Trichinella spp. in three Baltic countries: Lithuania, Latvia, and Estonia.
2007,
Pubmed
Mirbod,
Molecular cloning of a Rho family, CDC42Ca gene from Candida albicans and its mRNA expression changes during morphogenesis.
1997,
Pubmed
Nishimura,
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
2005,
Pubmed
Peterson,
Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition.
2004,
Pubmed
Qiu,
A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation.
2000,
Pubmed
Remonti,
Red fox (Vulpes vulpes) cannibalistic behaviour and the prevalence of Trichinella britovi in NW Italian Alps.
2005,
Pubmed
Schonegg,
CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos.
2006,
Pubmed
Schwamborn,
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
2004,
Pubmed
Solecki,
mPar6 alpha controls neuronal migration.
2006,
Pubmed
Sun,
Regulation of dynamic events by microfilaments during oocyte maturation and fertilization.
2006,
Pubmed
,
Xenbase
Taratuto,
Trichinosis.
1997,
Pubmed
Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed
Welchman,
Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types.
2007,
Pubmed
Wells,
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.
2006,
Pubmed
Wennerberg,
RhoG signals in parallel with Rac1 and Cdc42.
2002,
Pubmed
Yamanaka,
PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.
2001,
Pubmed
Yufu,
Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells.
2005,
Pubmed
Zhang,
A built-in arginine finger triggers the self-stimulatory GTPase-activating activity of rho family GTPases.
1999,
Pubmed
