Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Biochem Biophys Res Commun
2010 Nov 12;4022:241-6. doi: 10.1016/j.bbrc.2010.10.006.
Show Gene links
Show Anatomy links
Soluble factors from IL-1β-stimulated astrocytes activate NR1a/NR2B receptors: implications for HIV-1-induced neurodegeneration.
Jing T
,
Wu L
,
Borgmann K
,
Surendran S
,
Ghorpade A
,
Liu J
,
Xiong H
.
???displayArticle.abstract???
Astrocytes play an important role in astrocyte-neuron homeostasis. In HIV-1-infected brain, interleukin 1 beta (IL-1β) activation of astrocytes contributes to neurodegeneration. However, the molecular mechanisms underlying IL-1β-activated-astrocytes-induced neurodegeneration in HIV-1-infected brain are largely unknown. We hypothesize that secretory factors from the activated astrocytes affect N-methyl-d-aspartate (NMDA) receptor, a major pathway implicated in HIV-1-associated neurodegeneration. To test this hypothesis, we studied effects of IL-1β-stimulated astrocyte conditioned medium (ACM+) for its ability to activate NR1a/NR2B receptors expressed on Xenopus oocytes. Astrocytes treated with IL-1β 20ng/ml for 24h induced CXCL8, CCL2, MMP1 and MMP7. Pressure ejection of the ACM(+) produced an inward current in NR1a/NR2B-expressing oocytes. The inward current produced by ACM(+) was blocked by NMDA receptor antagonist, APV but not by non-NMDA receptor antagonist, CNQX. These results suggest that IL-1β stimulated astrocytes activate NR1a/NR2B receptors which may have implications in HIV-1-associated neurodegeneration.
Ahlemeyer,
Increase in glutamate-induced neurotoxicity by activated astrocytes involves stimulation of protein kinase C.
2002, Pubmed
Ahlemeyer,
Increase in glutamate-induced neurotoxicity by activated astrocytes involves stimulation of protein kinase C.
2002,
Pubmed
Bear,
Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.
1991,
Pubmed
,
Xenbase
Bliss,
A synaptic model of memory: long-term potentiation in the hippocampus.
1993,
Pubmed
Boven,
Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis.
2003,
Pubmed
Brack-Werner,
Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis.
1999,
Pubmed
Canki,
Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes.
2001,
Pubmed
Choi,
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
1988,
Pubmed
Collins,
Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms.
2010,
Pubmed
Deshpande,
Role of activated astrocytes in neuronal damage: potential links to HIV-1-associated dementia.
2005,
Pubmed
Dou,
Neuropathologic and neuroinflammatory activities of HIV-1-infected human astrocytes in murine brain.
2006,
Pubmed
Erichsen,
Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia.
2003,
Pubmed
Gardner,
Potential mechanisms for astrocyte-TIMP-1 downregulation in chronic inflammatory diseases.
2006,
Pubmed
Ghorpade,
HIV-1 and IL-1 beta regulate Fas ligand expression in human astrocytes through the NF-kappa B pathway.
2003,
Pubmed
Glass,
Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia.
1995,
Pubmed
Janabi,
Induction of human immunodeficiency virus type 1 replication in human glial cells after proinflammatory cytokines stimulation: effect of IFNgamma, IL1beta, and TNFalpha on differentiation and chemokine production in glial cells.
1998,
Pubmed
Kaul,
Pathways to neuronal injury and apoptosis in HIV-associated dementia.
2001,
Pubmed
Keblesh,
Pathogenesis of Human Immunodeficiency Virus Type-1 (HIV-1)-Associated Dementia: Role of Voltage-Gated Potassium Channels.
2008,
Pubmed
Kou,
CD38 regulation in activated astrocytes: implications for neuroinflammation and HIV-1 brain infection.
2009,
Pubmed
Levine,
CCL3 genotype and current depression increase risk of HIV-associated dementia.
2009,
Pubmed
Lipton,
Ca2+, N-methyl-D-aspartate receptors, and AIDS-related neuronal injury.
1994,
Pubmed
Lipton,
Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species.
1996,
Pubmed
Lipton,
AIDS-related dementia and calcium homeostasis.
1994,
Pubmed
Minagar,
The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis.
2002,
Pubmed
Müller,
Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1: induction and pharmacological intervention.
1996,
Pubmed
Peng,
HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
2006,
Pubmed
Reiner,
Methamphetamine abuse, HIV infection, and neurotoxicity.
2009,
Pubmed
Saito,
Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues.
1994,
Pubmed
Sas,
Cognitive dysfunction in HIV encephalitic SCID mice correlates with levels of Interferon-alpha in the brain.
2007,
Pubmed
Stys,
White matter NMDA receptors: an unexpected new therapeutic target?
2007,
Pubmed
Suryadevara,
Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia.
2003,
Pubmed
Takahashi,
Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry.
1996,
Pubmed
Toggas,
Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.
1996,
Pubmed
Traynelis,
Glutamate receptor ion channels: structure, regulation, and function.
2010,
Pubmed
Ushijima,
Exposure to gp120 of HIV-1 induces an increased release of arachidonic acid in rat primary neuronal cell culture followed by NMDA receptor-mediated neurotoxicity.
1995,
Pubmed
Xiong,
Activation of NR1a/NR2B receptors by monocyte-derived macrophage secretory products: implications for human immunodeficiency virus type one-associated dementia.
2003,
Pubmed
,
Xenbase
