Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-42186
Cancer Res 2000 Nov 15;6022:6303-6.
Show Gene links Show Anatomy links

The oncogenic potential of the high mobility group box protein Sox3.

Xia Y , Papalopulu N , Vogt PK , Li J .


???displayArticle.abstract???
Sox proteins belong to the superfamily of high mobility group (HMG) proteins. Sox3 is expressed predominantly in the immature neuroepithelium. Ectopic expression of Sox3 causes oncogenic transformation of chicken embryo fibroblasts (CEFs). The oncogenicity of Sox3 is correlated with nuclear localization and transcriptional regulatory activity; mutants containing deletions in the HMG box or the transactivation domain fail to induce foci of transformation. These observations suggest that Sox proteins can induce aberrant cell growth and strengthen the link of HMG proteins to oncogenesis.

???displayArticle.pubmedLink??? 11103788
???displayArticle.link??? Cancer Res
???displayArticle.grants??? [+]

Species referenced: Xenopus
Genes referenced: sox3