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XB-ART-42226
Proc Natl Acad Sci U S A 2010 Nov 16;10746:19885-90. doi: 10.1073/pnas.1003528107.
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Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation.

Wang R , Jung SY , Wu CF , Qin J , Kobayashi R , Gallick GE , Kuang J .


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The induction of M phase in eukaryotic cell cycles requires robust activation of Cdc2/cyclin B by Cdc25, which itself is robustly activated by serine/threonine phosphorylations. Although multiple protein kinases that directly activate Cdc25C have been identified, whether the combination of different primary phosphorylations of Cdc25C is sufficient to fully activate Cdc25C has not been determined. By analyzing the GST-Cdc25C phosphorylating activity in Xenopus egg extracts, we previously defined roles of MAPK and Cdc2/cyclin B in partially activating Cdc25C and predicted the presence of another major Cdc25C-activating kinase. In this study, we demonstrate that this missing kinase is RSK2, which phosphorylates three sites in Cdc25C and also partially activates Cdc25C. However, the phosphorylations catalyzed by MAPK, Cdc2, and RSK2 fail to fully activate Cdc25C, suggesting that additional biochemical events are required to fully activate this key cell cycle regulator.

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Species referenced: Xenopus
Genes referenced: ccnb1.2 cdc25c cdk1 mapk1 rasgrf1 rps6ka3

References [+] :
Anjum, The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. 2005, Pubmed