Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
The nuclear pore protein Nup153 is important for the transport of protein and RNA between the nucleus and cytoplasm. Recently, a novel RNA binding domain (RBD) was mapped within the N-terminal region of Nup153; however, the determinants of RNA association were not characterized. Here we have tested a range of RNAs with different general features to better understand targets recognized by this domain. We have found that the RBD associates with single-stranded RNA with little sequence preference. These results provide new information about a novel RNA binding domain and suggest new models to consider for the contribution of Nup153 to nucleocytoplasmic transport.
Bachi,
The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.
2000, Pubmed,
Xenbase
Bachi,
The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.
2000,
Pubmed
,
Xenbase
Bastos,
Targeting and function in mRNA export of nuclear pore complex protein Nup153.
1996,
Pubmed
Ben-Efraim,
Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import.
2001,
Pubmed
Dimaano,
RNA association defines a functionally conserved domain in the nuclear pore protein Nup153.
2001,
Pubmed
,
Xenbase
Duricka,
Analysis of RNA export using Xenopus oocytes.
2001,
Pubmed
,
Xenbase
Fahrenkrog,
The vertebrate nuclear pore complex: from structure to function.
2002,
Pubmed
Gwizdek,
Terminal minihelix, a novel RNA motif that directs polymerase III transcripts to the cell cytoplasm. Terminal minihelix and RNA export.
2001,
Pubmed
,
Xenbase
Gwizdek,
Exportin-5 mediates nuclear export of minihelix-containing RNAs.
2003,
Pubmed
,
Xenbase
Hamm,
In vitro assembly of U1 snRNPs.
1987,
Pubmed
,
Xenbase
Luo,
Splicing is required for rapid and efficient mRNA export in metazoans.
1999,
Pubmed
,
Xenbase
Marmier-Gourrier,
A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA.
2003,
Pubmed
Moroianu,
RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153.
1997,
Pubmed
Moroianu,
Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.
1995,
Pubmed
Morse,
RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA.
2002,
Pubmed
Nakielny,
Transportin: nuclear transport receptor of a novel nuclear protein import pathway.
1996,
Pubmed
Ohno,
Identity elements used in export of mRNAs.
2002,
Pubmed
,
Xenbase
Piñol-Roma,
Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.
1988,
Pubmed
Rodrigues,
REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus.
2001,
Pubmed
,
Xenbase
Rutjes,
Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs.
2001,
Pubmed
,
Xenbase
Shah,
Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors.
,
Pubmed
,
Xenbase
Shah,
Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr.
1998,
Pubmed
,
Xenbase
Suntharalingam,
Peering through the pore: nuclear pore complex structure, assembly, and function.
2003,
Pubmed
Ullman,
RNA export: searching for mRNA identity.
2002,
Pubmed
Ullman,
The nucleoporin nup153 plays a critical role in multiple types of nuclear export.
1999,
Pubmed
,
Xenbase
Weis,
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle.
2003,
Pubmed
