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Developing amphibians need vision to avoid predators and locate food before visual system circuits fully mature. Xenopus tadpoles can respond to visual stimuli as soon as retinal ganglion cells (RGCs) innervate the brain, however, in mammals, chicks and turtles, RGCs reach their central targets many days, or even weeks, before their retinas are capable of vision. In the absence of vision, activity-dependent refinement in these amniote species is mediated by waves of spontaneous activity that periodically spread across the retina, correlating the firing of action potentials in neighboring RGCs. Theory suggests that retinorecipient neurons in the brain use patterned RGC activity to sharpen the retinotopy first established by genetic cues. We find that in both wild type and albino Xenopus tadpoles, RGCs are spontaneously active at all stages of tadpole development studied, but their population activity never coalesces into waves. Even at the earliest stages recorded, visual stimulation dominates over spontaneous activity and can generate patterns of RGC activity similar to the locally correlated spontaneous activity observed in amniotes. In addition, we show that blocking AMPA and NMDA type glutamate receptors significantly decreases spontaneous activity in young Xenopus retina, but that blocking GABA(A) receptor blockers does not. Our findings indicate that vision drives correlated activity required for topographic map formation. They further suggest that developing retinal circuits in the two major subdivisions of tetrapods, amphibians and amniotes, evolved different strategies to supply appropriately patterned RGC activity to drive visual circuit refinement.
Aizenman,
Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo.
2003, Pubmed,
Xenbase
Aizenman,
Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo.
2003,
Pubmed
,
Xenbase
Aizenman,
Enhanced visual activity in vivo forms nascent synapses in the developing retinotectal projection.
2007,
Pubmed
,
Xenbase
Aizenman,
Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines.
2002,
Pubmed
,
Xenbase
Akerman,
Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo.
2006,
Pubmed
,
Xenbase
Cima,
Ontogeny of the retina and optic nerve of Xenopus laevis. IV. Ultrastructural evidence of early ganglion cell differentiation.
1980,
Pubmed
,
Xenbase
Cline,
Activity-dependent plasticity in the visual systems of frogs and fish.
1991,
Pubmed
Cline,
The regulation of dendritic arbor development and plasticity by glutamatergic synaptic input: a review of the synaptotrophic hypothesis.
2008,
Pubmed
Demas,
Developmental loss of synchronous spontaneous activity in the mouse retina is independent of visual experience.
2003,
Pubmed
Dong,
Visual avoidance in Xenopus tadpoles is correlated with the maturation of visual responses in the optic tectum.
2009,
Pubmed
,
Xenbase
Engert,
Moving visual stimuli rapidly induce direction sensitivity of developing tectal neurons.
2002,
Pubmed
,
Xenbase
He,
Light-evoked synaptic activity of retinal ganglion and amacrine cells is regulated in developing mouse retina.
2011,
Pubmed
Holt,
Order in the initial retinotectal map in Xenopus: a new technique for labelling growing nerve fibres.
1983,
Pubmed
,
Xenbase
Huberman,
Mechanisms underlying development of visual maps and receptive fields.
2008,
Pubmed
Keating,
Visual deprivation and the maturation of the retinotectal projection in Xenopus laevis.
1986,
Pubmed
,
Xenbase
Kerschensteiner,
Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina.
2008,
Pubmed
Lee,
Segregation of ON and OFF retinogeniculate connectivity directed by patterned spontaneous activity.
2002,
Pubmed
Li,
In vivo time-lapse imaging and serial section electron microscopy reveal developmental synaptic rearrangements.
2011,
Pubmed
,
Xenbase
Meister,
Multi-neuronal signals from the retina: acquisition and analysis.
1994,
Pubmed
Pratt,
Homeostatic regulation of intrinsic excitability and synaptic transmission in a developing visual circuit.
2007,
Pubmed
,
Xenbase
Ruthazer,
Stabilization of axon branch dynamics by synaptic maturation.
2006,
Pubmed
,
Xenbase
Ruthazer,
Control of axon branch dynamics by correlated activity in vivo.
2003,
Pubmed
,
Xenbase
Sernagor,
Influence of spontaneous activity and visual experience on developing retinal receptive fields.
1996,
Pubmed
Sernagor,
Developmental modulation of retinal wave dynamics: shedding light on the GABA saga.
2003,
Pubmed
Sernagor,
Spontaneous activity in developing turtle retinal ganglion cells: pharmacological studies.
1999,
Pubmed
Sin,
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases.
2002,
Pubmed
,
Xenbase
Syed,
Stage-dependent dynamics and modulation of spontaneous waves in the developing rabbit retina.
2004,
Pubmed
Tao,
Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields.
2005,
Pubmed
,
Xenbase
Tao,
Emergence of input specificity of ltp during development of retinotectal connections in vivo.
2001,
Pubmed
,
Xenbase
Vislay-Meltzer,
Spatiotemporal specificity of neuronal activity directs the modification of receptive fields in the developing retinotectal system.
2006,
Pubmed
,
Xenbase
Wong,
Rapid dendritic remodeling in the developing retina: dependence on neurotransmission and reciprocal regulation by Rac and Rho.
2000,
Pubmed
Wong,
Retinal waves and visual system development.
1999,
Pubmed
Wong,
Transient period of correlated bursting activity during development of the mammalian retina.
1993,
Pubmed
Zhou,
Reversal and stabilization of synaptic modifications in a developing visual system.
2003,
Pubmed
,
Xenbase
