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We found a previously unknown form of homeostatic synaptic plasticity in multisensory neurons in the optic tectum of Xenopus laevis tadpoles. Individual tectal neurons are known to receive converging inputs from multiple sensory modalities. We observed that long-term alterations in either visual or mechanosensory activity in vivo resulted in homeostatic changes specific to each sensory modality. In contrast with typical forms of homeostatic synaptic plasticity, such as synaptic scaling, we found that this type of plasticity occurred in a pathway-specific manner that is more reminiscent of hebbian-type plasticity.
Figure 2. Modality-specific changes in aEPSC amplitude after various sensory manipulations(A) aEPSCs evoked by visual or hindbrain stimulation after 48 hours of visual deprivation (left), enhanced mechanosensory stimulation (middle) or enhanced mechanosensory stimulation in the presence of inhibitory blockers (right). (B) Comparison of hindbrain and visual stimulation after various experimental conditions. Symbols next to paired data represent average values and error bars are SEM. (C) Scatterplot of aEPSC amplitude evoked by each pathway after various experimental conditions. (E) Cumulative probability distribution of aEPSC amplitudes from both pathways superimposed with spontaneous EPSC (sEPSC) amplitudes after various experimental conditions. Stars indicate p<0.05.
Figure 3. Summary of synaptic changes after in vivo sensory manipulations(A) Averaged data comparing aEPSC amplitude evoked by visual and mechanosensory pathways under various conditions. Notice modality specific changes. (B) Cumulative probability plots of sEPSC amplitudes from different experimental groups. Inset shows average sEPSC amplitudes across conditions. Error bars are SEM, stars indicate p<0.05. For direct comparisons see Sup. Fig. 5.
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