Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Neurochem Res
2011 Apr 01;364:627-35. doi: 10.1007/s11064-010-0146-y.
Show Gene links
Show Anatomy links
Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II α phosphatidylinositol-5-phosphate 4-kinase.
???displayArticle.abstract???
Type II phosphatidylinositol 5-phosphate 4-kinase (PIPKIIα) catalyzes the synthesis of phosphatidylinositol-4,5-bisphosphate (PI-4,5-P(2)), an essential lipid second messenger that may be involved in the regulation of phototransduction, neuroprotection, and morphogenesis in the vertebrate retina. Here we report that in rodent and transgenic frogs, the light-mediated activity and membrane binding of PIPKIIα in rod outer segments (ROS) is dependent on tyrosine phosphorylation of ROS proteins. The greater type II α PIP kinase activity in the light-adapted ROS membrane results from light-driven translocation of PIPKIIα from the rod inner segment to ROS, and subsequent binding to the ROS membrane, thus improving access of the kinase to its lipid substrates. These results indicate a novel mechanism of light regulation of the PIPKIIα activity in photoreceptors, and suggest that the greater PIPKIIα activity in light-adapted animals and the resultant accumulation of PI-4,5-P(2) within the ROS membrane may be important for the function of photoreceptor cells.
???displayArticle.pubmedLink???
20204506
???displayArticle.pmcLink???PMC4227407 ???displayArticle.link???Neurochem Res ???displayArticle.grants???[+]
Aikawa,
ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis.
2003, Pubmed
Aikawa,
ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis.
2003,
Pubmed
Bazenet,
The human erythrocyte contains two forms of phosphatidylinositol-4-phosphate 5-kinase which are differentially active toward membranes.
1990,
Pubmed
Bell,
Association of the tyrosine phosphatase SHP-2 with transducin-alpha and a 97-kDa tyrosine-phosphorylated protein in photoreceptor rod outer segments.
1999,
Pubmed
Botelho,
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
2000,
Pubmed
Castellino,
Differential association of phosphatidylinositol-5-phosphate 4-kinase with the EGF/ErbB family of receptors.
1999,
Pubmed
Chuang,
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.
2007,
Pubmed
Ciruela,
Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7.
2000,
Pubmed
Di Paolo,
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking.
2004,
Pubmed
Djordjevic,
Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases.
2002,
Pubmed
Doughman,
Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place.
2003,
Pubmed
Ghalayini,
Light stimulates tyrosine phosphorylation of rat rod outer segments In vivo.
1998,
Pubmed
Ghalayini,
Phosphatidylinositol 4,5-bisphosphate: light-mediated breakdown in the vertebrate retina.
1984,
Pubmed
Ghalayini,
Light adaptation of bovine retinas in situ stimulates phosphatidylinositol synthesis in rod outer segments in vitro.
1995,
Pubmed
Ghalayini,
Phospholipase Cgamma1 in bovine rod outer segments: immunolocalization and light-dependent binding to membranes.
1998,
Pubmed
Giusto,
Lipid second messengers and related enzymes in vertebrate rod outer segments.
2010,
Pubmed
Guo,
A Dictyostelium nuclear phosphatidylinositol phosphate kinase required for developmental gene expression.
2001,
Pubmed
Guo,
Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments.
1997,
Pubmed
Hayashi,
Light-mediated breakdown of phosphatidylinositol-4,5-bisphosphate in isolated rod outer segments of frog photoreceptor.
1985,
Pubmed
He,
Enhancement of phototransduction g protein-effector interactions by phosphoinositides.
2004,
Pubmed
Hinchliffe,
Regulation of type II PIP kinase by PKD phosphorylation.
2006,
Pubmed
Huang,
Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.
2004,
Pubmed
Huang,
Regulation of type II phosphatidylinositol phosphate kinase by tyrosine phosphorylation in bovine rod outer segments.
2001,
Pubmed
Huang,
Light-mediated activation of diacylglycerol kinase in rat and bovine rod outer segments.
2000,
Pubmed
Itoh,
Regulation of endocytosis by phosphatidylinositol 4,5-bisphosphate and ENTH proteins.
2004,
Pubmed
Itoh,
A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals.
1998,
Pubmed
Kapoor,
Phorbol ester- and light-induced endogenous phosphorylation of rat rod outer-segment proteins.
1987,
Pubmed
Ling,
Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.
2003,
Pubmed
Ling,
Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.
2006,
Pubmed
Logan,
Regulation of the actin cytoskeleton by PIP2 in cytokinesis.
2006,
Pubmed
McLaughlin,
PIP(2) and proteins: interactions, organization, and information flow.
2002,
Pubmed
Millar,
Polyphosphoinositide hydrolysis in response to light stimulation of rat and chick retina and retinal rod outer segments.
1988,
Pubmed
Newton,
Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors.
1993,
Pubmed
Nishizuka,
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.
1992,
Pubmed
Park,
Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli.
2001,
Pubmed
Pasquaré,
Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina.
2008,
Pubmed
Pasquaré,
Effect of light on phosphatidate phosphohydrolase activity of retina rod outer segments: the role of transducin.
2000,
Pubmed
Rajala,
In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit.
2002,
Pubmed
Rajala,
G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor.
2007,
Pubmed
Rameh,
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
1997,
Pubmed
Rümenapp,
Tyrosine-phosphorylation-dependent and rho-protein-mediated control of cellular phosphatidylinositol 4,5-bisphosphate levels.
1998,
Pubmed
Suh,
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.
2005,
Pubmed
Udovichenko,
Functional effect of phosphorylation of the photoreceptor phosphodiesterase inhibitory subunit by protein kinase C.
1994,
Pubmed
Udovichenko,
Protein kinase C in rod outer segments: effects of phosphorylation of the phosphodiesterase inhibitory subunit.
1996,
Pubmed
Udovichenko,
Contribution of protein kinase C to the phosphorylation of rhodopsin in intact retinas.
1997,
Pubmed
Wahlin,
A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells.
2004,
Pubmed
Wiechmann,
Direct modulation of rod photoreceptor responsiveness through a Mel(1c) melatonin receptor in transgenic Xenopus laevis retina.
2003,
Pubmed
,
Xenbase
Wolbring,
Activation by PKC of the Ca(2+)-sensitive guanylyl cyclase in bovine retinal rod outer segments measured with an optical assay.
1995,
Pubmed
Womack,
Do phosphatidylinositides modulate vertebrate phototransduction?
2000,
Pubmed
,
Xenbase
