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ACS Med Chem Lett
2010 Oct 08;21:39-42. doi: 10.1021/ml1001954.
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Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.
Fass DM
,
Shah R
,
Ghosh B
,
Hennig K
,
Norton S
,
Zhao WN
,
Reis SA
,
Klein PS
,
Mazitschek R
,
Maglathlin RL
,
Lewis TA
,
Haggarty SJ
.
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Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in human cervical carcinoma Hela cells and primary cultures from mouse forebrain, and a whole animal (Xenopus laevis) developmental assay. Relative to the parent carboxylic acids, two of these analogs exhibited enhanced potency, and one analog showed altered HDAC isoform selectivity and in vivo activity in the Xenopus assay. We discuss potential uses of these novel hydroxamic acids in studies aimed at determining the utility of HDAC inhibitors as memory enhancers and mood stabilizers.
Bradner,
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Bradner,
Chemical phylogenetics of histone deacetylases.
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Clark,
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2009,
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Dash,
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2009,
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Dickerson,
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2010,
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Eikel,
S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides.
2006,
Pubmed
Fischer,
Recovery of learning and memory is associated with chromatin remodelling.
2007,
Pubmed
Fishbein,
Preparation and some properties of stable and carbon-14 and tritium-labeled short-chain aliphatic hydroxamic acids.
1969,
Pubmed
Göttlicher,
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.
2001,
Pubmed
Gurvich,
Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo.
2005,
Pubmed
,
Xenbase
Gurvich,
Histone deacetylase is a target of valproic acid-mediated cellular differentiation.
2004,
Pubmed
Haddad,
A review of valproate in psychiatric practice.
2009,
Pubmed
Huang,
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
1989,
Pubmed
Hubbert,
HDAC6 is a microtubule-associated deacetylase.
2002,
Pubmed
Kavanaugh,
Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma.
2010,
Pubmed
Kilgore,
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.
2010,
Pubmed
Lea,
Induction of histone acetylation and growth regulation in eryrthroleukemia cells by 4-phenylbutyrate and structural analogs.
1999,
Pubmed
Levenson,
Regulation of histone acetylation during memory formation in the hippocampus.
2004,
Pubmed
Levi,
Pharmacokinetics and antiepileptic activity of valproyl hydroxamic acid derivatives.
1997,
Pubmed
Löscher,
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
2002,
Pubmed
Phiel,
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.
2001,
Pubmed
,
Xenbase
Ricobaraza,
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
2009,
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Skarpidi,
Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression.
2003,
Pubmed
Stefanko,
Modulation of long-term memory for object recognition via HDAC inhibition.
2009,
Pubmed
Tessier,
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
2009,
Pubmed
Walia,
Side effects of antiepileptics--a review.
2004,
Pubmed
