XB-ART-44232
Nat Rev Mol Cell Biol
2011 Jun 23;127:453-9. doi: 10.1038/nrm3140.
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Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?
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Differentiated cells can be experimentally reprogrammed back to pluripotency by nuclear transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell fusion can lead to efficient reprogramming of gene expression. The egg and oocyte reprogramming process includes the exchange of somatic proteins for oocyte proteins, the post-translational modification of histones and the demethylation of DNA. These events occur in an ordered manner and on a defined timescale, indicating that reprogramming by nuclear transfer and by cell fusion rely on deterministic processes.
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RHG54943 Wellcome Trust , 079948 Wellcome Trust , 081277 Wellcome Trust , G1001690 Medical Research Council , MRC_G1001690 Medical Research Council , WT079948 Wellcome Trust , WT081277 Wellcome Trust
Species referenced: Xenopus laevis
References [+] :
Barreto,
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.
2007, Pubmed,
Xenbase
Barreto, Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. 2007, Pubmed , Xenbase
Bhutani, Reprogramming towards pluripotency requires AID-dependent DNA demethylation. 2010, Pubmed
Bian, Epigenetic marks in somatic chromatin are remodelled to resemble pluripotent nuclei by amphibian oocyte extracts. 2009, Pubmed
Biddle, Xenopus oocytes reactivate muscle gene transcription in transplanted somatic nuclei independently of myogenic factors. 2009, Pubmed , Xenbase
Blau, Plasticity of the differentiated state. 1985, Pubmed
Blau, Cytoplasmic activation of human nuclear genes in stable heterocaryons. 1983, Pubmed
Blelloch, Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. 2006, Pubmed
Boiani, Oct4 distribution and level in mouse clones: consequences for pluripotency. 2002, Pubmed
Bortvin, Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. 2003, Pubmed
Byrne, Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes. 2003, Pubmed , Xenbase
Campbell, Sheep cloned by nuclear transfer from a cultured cell line. 1996, Pubmed
Chuang, Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter. 2011, Pubmed
D'Alessio, Shifting players and paradigms in cell-specific transcription. 2009, Pubmed
Efroni, Global transcription in pluripotent embryonic stem cells. 2008, Pubmed
Eggan, Mice cloned from olfactory sensory neurons. 2004, Pubmed
Egli, Reprogramming after chromosome transfer into mouse blastomeres. 2009, Pubmed
Egli, Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. 2007, Pubmed
Epsztejn-Litman, De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. 2008, Pubmed
Feldman, G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. 2006, Pubmed
Ficz, Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. 2011, Pubmed
Gao, Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice. 2004, Pubmed
Gao, Nuclear reprogramming: the strategy used in normal development is also used in somatic cell nuclear transfer and parthenogenesis. 2007, Pubmed
Goodrich, Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation. 2010, Pubmed
Greda, Mouse zygotes as recipients in embryo cloning. 2006, Pubmed
Gu, Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation. 2005, Pubmed
Gu, Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. 2005, Pubmed
Gurdon, Injected nuclei in frog oocytes:RNA synthesis and protein exchange. 1976, Pubmed , Xenbase
Gurdon, Changes in somatic cell nuclei inserted into growing and maturing amphibian oocytes. 1968, Pubmed , Xenbase
GURDON, The developmental capacity of nuclei taken from differentiating endoderm cells of Xenopus laevis. 1960, Pubmed , Xenbase
GURDON, Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. 1958, Pubmed , Xenbase
Halley-Stott, Mammalian nuclear transplantation to Germinal Vesicle stage Xenopus oocytes - a method for quantitative transcriptional reprogramming. 2010, Pubmed , Xenbase
Hanna, Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. 2008, Pubmed
Hanna, Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. 2010, Pubmed
Hanna, Direct cell reprogramming is a stochastic process amenable to acceleration. 2009, Pubmed
Harris, The reactivation of the red cell nucleus. 1967, Pubmed
Hiiragi, Reprogramming is essential in nuclear transfer. 2005, Pubmed
Inoue, Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer. 2010, Pubmed
Ito, Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. 2010, Pubmed
Jullien, Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation. 2010, Pubmed , Xenbase
Kikyo, Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI. 2000, Pubmed , Xenbase
Kimura, Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B. 2001, Pubmed
Kimura, Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. 2004, Pubmed
Kishigami, Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. 2006, Pubmed
Koche, Reprogramming factor expression initiates widespread targeted chromatin remodeling. 2011, Pubmed
Meshorer, Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. 2006, Pubmed
Misteli, Dynamic binding of histone H1 to chromatin in living cells. 2000, Pubmed
Miyamoto, Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. 2011, Pubmed , Xenbase
Murata, Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes. 2010, Pubmed , Xenbase
Ng, Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. 2005, Pubmed , Xenbase
Pasque, Efficiencies and mechanisms of nuclear reprogramming. 2010, Pubmed
Pasque, Histone variant macroH2A confers resistance to nuclear reprogramming. 2011, Pubmed , Xenbase
Pereira, Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. 2008, Pubmed
Pfeiffer, Proteomic analysis of mouse oocytes reveals 28 candidate factors of the "reprogrammome". 2011, Pubmed
Phair, Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. 2004, Pubmed
Rechsteiner, Microinjection of the nonhistone chromosomal protein HMG1 into bovine fibroblasts and HeLa cells. 1979, Pubmed
Saeki, Linker histone variants control chromatin dynamics during early embryogenesis. 2005, Pubmed , Xenbase
Schmiedeberg, High- and low-mobility populations of HP1 in heterochromatin of mammalian cells. 2004, Pubmed
Simonsson, DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. 2004, Pubmed , Xenbase
Smith, Simultaneous gene quantitation of multiple genes in individual bovine nuclear transfer blastocysts. 2007, Pubmed
Smith, Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning. 2005, Pubmed
Smith, Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. 2010, Pubmed
Sridharan, Role of the murine reprogramming factors in the induction of pluripotency. 2009, Pubmed
Stadtfeld, Induced pluripotency: history, mechanisms, and applications. 2010, Pubmed
Stadtfeld, Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. 2008, Pubmed
Takahashi, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 2006, Pubmed
Tamada, Chromatin decondensation and nuclear reprogramming by nucleoplasmin. 2006, Pubmed , Xenbase
Taranger, Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. 2005, Pubmed
Teranishi, Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. 2004, Pubmed , Xenbase
Terranova, Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming. 2006, Pubmed
Wossidlo, Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes. 2010, Pubmed
Wossidlo, 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. 2011, Pubmed
Wu, Dynamic behavior of histone H1 microinjected into HeLa cells. 1986, Pubmed
Yamanaka, Elite and stochastic models for induced pluripotent stem cell generation. 2009, Pubmed
Yamanaka, Nuclear reprogramming to a pluripotent state by three approaches. 2010, Pubmed