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XB-ART-44785
Biochimie 2011 Nov 01;9311:1955-61. doi: 10.1016/j.biochi.2011.07.008.
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Binary function of mRNA.

Kloc M , Foreman V , Reddy SA .


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Since the discovery of messenger RNA (mRNA) over half a century ago, the assumption has always been that the only function of mRNA is to make a protein. However, recent studies of prokaryotic and eukaryotic organisms unexpectedly show that some mRNAs may be functionally binary and have additional structural functions that are unrelated to their translation product. These findings imply that some of the phenotypic features of cells and organisms can also be binary, that is, they depend both on the function of a protein and the independent structural function of its mRNA. In this review, we will discuss this concept within the framework of multifunctional RNA molecules and the RNA World Hypothesis.

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