Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Members of the leucine zipper putative tumor suppressor (LZTS) family play crucial roles in transcription modulation and cell cycle control. We previously demonstrated that LZTS2 functions as a novel β-catenin-interacting protein and represses β-catenin-mediated transcription on T-cell factor/lymphoid enhancing factor. Here, we investigate the biological role of LZTS2 using newly established Lzts2 KO mice. Homozygosity for loss-of-function of the Lzts2-targeted allele resulted in severe kidney and urinary tract developmental defects, including renal/ureteral duplication, hydroureter, and hydronephrosis, which were visible prenatally. Altered ureteric bud outgrowth was identified in Lzts2 null embryos. Further analysis indicated that β-catenin subcellular localization was altered in fibroblasts isolated from Lzts2 null embryos. In addition, Wnt growth factor-induced β-catenin-mediated transcriptional activity was increased in Lzts2 null fibroblasts, suggesting a direct role for Lzts2 in the Wnt signaling pathway. These data demonstrate a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of β-catenin-mediated nephrogenesis.
Basson,
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.
2006, Pubmed
Basson,
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.
2006,
Pubmed
Beliakoff,
The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
2008,
Pubmed
Bridgewater,
Canonical WNT/beta-catenin signaling is required for ureteric branching.
2008,
Pubmed
Cabeza-Arvelaiz,
LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.
2001,
Pubmed
Chen,
Genetic and developmental basis for urinary tract obstruction.
2009,
Pubmed
Costantini,
GDNF/Ret signaling and the development of the kidney.
2006,
Pubmed
Dressler,
Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.
1993,
Pubmed
Gray,
Mouse brain organization revealed through direct genome-scale TF expression analysis.
2004,
Pubmed
Hyun Hwa Cho,
Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells.
2008,
Pubmed
Ichikawa,
Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT.
2002,
Pubmed
Iglesias,
Canonical WNT signaling during kidney development.
2007,
Pubmed
Kerecuk,
Renal tract malformations: perspectives for nephrologists.
2008,
Pubmed
Kobayashi,
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development.
2005,
Pubmed
,
Xenbase
Lakso,
Targeted oncogene activation by site-specific recombination in transgenic mice.
1992,
Pubmed
Li,
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
1997,
Pubmed
Mahoney,
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.
2006,
Pubmed
Marose,
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state.
2008,
Pubmed
,
Xenbase
Moore,
Renal and neuronal abnormalities in mice lacking GDNF.
1996,
Pubmed
Pachnis,
Expression of the c-ret proto-oncogene during mouse embryogenesis.
1993,
Pubmed
Park,
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.
2007,
Pubmed
Peng,
A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.
2010,
Pubmed
Peters,
Animal models of fetal renal disease.
2001,
Pubmed
Pichel,
Defects in enteric innervation and kidney development in mice lacking GDNF.
1996,
Pubmed
Qian,
Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.
2005,
Pubmed
Rodríguez,
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP.
2000,
Pubmed
Rosenthal,
The GDNF protein family: gene ablation studies reveal what they really do and how.
1999,
Pubmed
Saadi-Kheddouci,
Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene.
2001,
Pubmed
Sainio,
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium.
1997,
Pubmed
Saxén,
Early organogenesis of the kidney.
1987,
Pubmed
Schmeisser,
Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses.
2009,
Pubmed
Sharma,
hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci.
2003,
Pubmed
Sudo,
LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin.
2007,
Pubmed
Sudo,
LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing.
2008,
Pubmed
Teufel,
In silico characterization of LZTS3, a potential tumor suppressor.
2005,
Pubmed
Thyssen,
LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
2006,
Pubmed
Vecchione,
Fez1/lzts1 alterations in gastric carcinoma.
2001,
Pubmed
Vecchione,
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
2007,
Pubmed
Verras,
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells.
2004,
Pubmed
