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Magenheim J
,
Ilovich O
,
Lazarus A
,
Klochendler A
,
Ziv O
,
Werman R
,
Hija A
,
Cleaver O
,
Mishani E
,
Keshet E
,
Dor Y
.
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How organ size and form are controlled during development is a major question in biology. Blood vessels have been shown to be essential for early development of the liver and pancreas, and are fundamental to normal and pathological tissue growth. Here, we report that, surprisingly, non-nutritional signals from blood vessels act to restrain pancreas growth. Elimination of endothelial cells increases the size of embryonic pancreatic buds. Conversely, VEGF-induced hypervascularization decreases pancreas size. The growth phenotype results from vascular restriction of pancreatic tip cell formation, lateral branching and differentiation of the pancreatic epithelium into endocrine and acinar cells. The effects are seen both in vivo and ex vivo, indicating a perfusion-independent mechanism. Thus, the vasculature controls pancreas morphogenesis and growth by reducing branching and differentiation of primitive epithelial cells.
Ahnfelt-Rønne,
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.
2007, Pubmed
Ahnfelt-Rønne,
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.
2007,
Pubmed
Ahnfelt-Rønne,
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas.
2007,
Pubmed
Apelqvist,
Notch signalling controls pancreatic cell differentiation.
1999,
Pubmed
,
Xenbase
Butler,
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors.
2010,
Pubmed
Butler,
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
2010,
Pubmed
D'Amour,
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells.
2006,
Pubmed
Dor,
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects.
2001,
Pubmed
Esni,
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas.
2004,
Pubmed
Gittes,
Developmental biology of the pancreas: a comprehensive review.
2009,
Pubmed
Gu,
Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
2004,
Pubmed
Hald,
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.
2003,
Pubmed
Hart,
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.
2003,
Pubmed
Holland,
Experimental control of pancreatic development and maintenance.
2002,
Pubmed
Ilovich,
Formation of fluorine-18 labeled diaryl ureas--labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis.
2008,
Pubmed
Jacquemin,
An endothelial-mesenchymal relay pathway regulates early phases of pancreas development.
2006,
Pubmed
Jørgensen,
An illustrated review of early pancreas development in the mouse.
2007,
Pubmed
Kesavan,
Cdc42-mediated tubulogenesis controls cell specification.
2009,
Pubmed
Kroon,
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.
2008,
Pubmed
Lammert,
Induction of pancreatic differentiation by signals from blood vessels.
2001,
Pubmed
,
Xenbase
LeCouter,
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.
2003,
Pubmed
Magenheim,
Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium.
2011,
Pubmed
Matsumoto,
Liver organogenesis promoted by endothelial cells prior to vascular function.
2001,
Pubmed
May,
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation.
2008,
Pubmed
Murtaugh,
Notch signaling controls multiple steps of pancreatic differentiation.
2003,
Pubmed
Murtaugh,
Pancreas and beta-cell development: from the actual to the possible.
2007,
Pubmed
Nikolova,
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
2006,
Pubmed
Norgaard,
FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.
2003,
Pubmed
Oliver-Krasinski,
On the origin of the beta cell.
2008,
Pubmed
Palmer,
Vascular niche for adult hippocampal neurogenesis.
2000,
Pubmed
Pierreux,
Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.
2010,
Pubmed
Puri,
Dynamics of embryonic pancreas development using real-time imaging.
2007,
Pubmed
Sand,
Growth-limiting role of endothelial cells in endoderm development.
2011,
Pubmed
Shalaby,
A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis.
1997,
Pubmed
Shen,
Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells.
2004,
Pubmed
Shen,
Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions.
2008,
Pubmed
Solar,
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.
2009,
Pubmed
Tang,
White fat progenitor cells reside in the adipose vasculature.
2008,
Pubmed
Tavazoie,
A specialized vascular niche for adult neural stem cells.
2008,
Pubmed
van Eyll,
Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A.
2004,
Pubmed
Yoshida,
A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis.
2007,
Pubmed
Yoshitomi,
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.
2004,
Pubmed
Zaret,
Pancreatic beta cells: responding to the matrix.
2006,
Pubmed
Zaret,
Generation and regeneration of cells of the liver and pancreas.
2008,
Pubmed
Zhou,
A multipotent progenitor domain guides pancreatic organogenesis.
2007,
Pubmed
