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Development
2010 Dec 01;13724:4295-305. doi: 10.1242/dev.052993.
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Epithelial dynamics of pancreatic branching morphogenesis.
Villasenor A
,
Chong DC
,
Henkemeyer M
,
Cleaver O
.
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The mammalian pancreas is a highly branched gland, essential for both digestion and glucose homeostasis. Pancreatic branching, however, is poorly understood, both at the ultrastructural and cellular levels. In this article, we characterize the morphogenesis of pancreatic branches, from gross anatomy to the dynamics of their epithelial organization. We identify trends in pancreatic branch morphology and introduce a novel mechanism for branch formation, which involves transient epithelial stratification and partial loss of cell polarity, changes in cell shape and cell rearrangements, de novo tubulogenesis and epithelial tubule remodeling. In contrast to the classical epithelial budding and tube extension observed in other organs, a pancreatic branch takes shape as a multi-lumen tubular plexus coordinately extends and remodels into a ramifying, single-lumen ductal system. Moreover, our studies identify a role for EphB signaling in epithelial remodeling during pancreatic branching. Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ.
Andrew,
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.
2010, Pubmed
Andrew,
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.
2010,
Pubmed
Batlle,
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
2002,
Pubmed
Böck,
Development of pancreas.
,
Pubmed
Bonal,
Genes controlling pancreas ontogeny.
2008,
Pubmed
Dessimoz,
Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.
2005,
Pubmed
García-Ceca,
On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network.
2009,
Pubmed
Gittes,
Developmental biology of the pancreas: a comprehensive review.
2009,
Pubmed
Gottardi,
Adhesion signaling: how beta-catenin interacts with its partners.
2001,
Pubmed
Gu,
Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis.
2003,
Pubmed
Heiser,
Stabilization of beta-catenin impacts pancreas growth.
2006,
Pubmed
Hogan,
Morphogenesis.
1999,
Pubmed
Hogg,
Lumen formation in the developing mouse mammary gland.
1983,
Pubmed
Holmberg,
EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.
2006,
Pubmed
Horne-Badovinac,
Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis.
2001,
Pubmed
Jensen,
Gene regulatory factors in pancreatic development.
2004,
Pubmed
Jones,
What determines blood vessel structure? Genetic prespecification vs. hemodynamics.
2006,
Pubmed
Jørgensen,
An illustrated review of early pancreas development in the mouse.
2007,
Pubmed
Kawaguchi,
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.
2002,
Pubmed
Kesavan,
Cdc42-mediated tubulogenesis controls cell specification.
2009,
Pubmed
Lechler,
Asymmetric cell divisions promote stratification and differentiation of mammalian skin.
2005,
Pubmed
Lu,
Patterning mechanisms of branched organs.
2008,
Pubmed
Mailleux,
Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models.
2008,
Pubmed
Masui,
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.
2008,
Pubmed
Metzger,
The branching programme of mouse lung development.
2008,
Pubmed
Miao,
Eph/ephrin signaling in epithelial development and homeostasis.
2009,
Pubmed
Muñoz,
Organizing the thymus gland.
2009,
Pubmed
Murtaugh,
Genes, signals, and lineages in pancreas development.
2003,
Pubmed
Murtaugh,
Beta-catenin is essential for pancreatic acinar but not islet development.
2005,
Pubmed
Offield,
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
1996,
Pubmed
,
Xenbase
Oliver-Krasinski,
On the origin of the beta cell.
2008,
Pubmed
Pierreux,
The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.
2006,
Pubmed
Puri,
Dynamics of embryonic pancreas development using real-time imaging.
2007,
Pubmed
Risau,
Vasculogenesis.
1995,
Pubmed
Slack,
Developmental biology of the pancreas.
1995,
Pubmed
Sternlicht,
Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis.
2006,
Pubmed
Tucker,
Salivary gland development.
2007,
Pubmed
van Eyll,
Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.
2006,
Pubmed
Villasenor,
Biphasic Ngn3 expression in the developing pancreas.
2008,
Pubmed
,
Xenbase
Walker,
Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures.
2008,
Pubmed
Wells,
Wnt/beta-catenin signaling is required for development of the exocrine pancreas.
2007,
Pubmed
Zhou,
A multipotent progenitor domain guides pancreatic organogenesis.
2007,
Pubmed
