XB-ART-4713
Dev Cell
2003 Sep 01;53:359-60. doi: 10.1016/s1534-5807(03)00267-3.
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Methylation gets SMRT. Functional insights into Rett syndrome.
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Rett syndrome, a neurodevelopmental disorder, is caused by mutations in the methyl-CpG binding protein MeCP2. A recent report demonstrates that MeCP2 cooperates with the SMRT corepressor complex to inhibit expression of a hairy-related repressor during primary neurogenesis in Xenopus, and that this can be modulated by Notch signaling. Rett syndrome mutations that disrupt interaction with the SMRT corepressor complex also prevent regulation of MeCP2 by activated Notch."Well-timed silence hath more eloquence than speech."-Martin Farquhar Tupper (1810-1889)
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Species referenced: Xenopus
Genes referenced: dll1 hdac3 hes4 mecp2 ncor2 notch1 rbpj sin3a