Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Janganati V
,
Penthala NR
,
Cragle CE
,
MacNicol AM
,
Crooks PA
.
???displayArticle.abstract???
Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression.
Bagowski,
The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes.
2001, Pubmed,
Xenbase
Bagowski,
The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes.
2001,
Pubmed
,
Xenbase
Bork,
Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB.
1997,
Pubmed
Cross,
Learning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts.
2009,
Pubmed
,
Xenbase
Dupré,
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
2008,
Pubmed
,
Xenbase
Dush,
Heterotaxin: a TGF-β signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos.
2011,
Pubmed
,
Xenbase
Ferrell,
Xenopus oocyte maturation: new lessons from a good egg.
1999,
Pubmed
,
Xenbase
Flament,
Differential effects of 6-DMAP, olomoucine and roscovitine on Xenopus oocytes and eggs.
2000,
Pubmed
,
Xenbase
Gaffré,
A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes.
2011,
Pubmed
,
Xenbase
Gard,
F-actin is required for spindle anchoring and rotation in Xenopus oocytes: a re-examination of the effects of cytochalasin B on oocyte maturation.
1995,
Pubmed
,
Xenbase
Gross,
The critical role of the MAP kinase pathway in meiosis II in Xenopus oocytes is mediated by p90(Rsk).
2000,
Pubmed
,
Xenbase
Grzmil,
Translation regulation as a therapeutic target in cancer.
2012,
Pubmed
Guzman,
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
2005,
Pubmed
Guzman,
Feverfew: weeding out the root of leukaemia.
2005,
Pubmed
Hehner,
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.
1998,
Pubmed
Howard,
The mitogen-activated protein kinase signaling pathway stimulates mos mRNA cytoplasmic polyadenylation during Xenopus oocyte maturation.
1999,
Pubmed
,
Xenbase
Huchon,
Microtubules during germinal vesicle breakdown (GVBD) of Xenopus oocytes: effect of Ca2+ ionophore A-23187 and taxol.
1985,
Pubmed
,
Xenbase
Jessus,
Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte. Antagonistic action of okadaic acid and 6-DMAP.
1991,
Pubmed
,
Xenbase
Kälin,
An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis.
2009,
Pubmed
,
Xenbase
Keady,
MAPK interacts with XGef and is required for CPEB activation during meiosis in Xenopus oocytes.
2007,
Pubmed
,
Xenbase
Knight,
Feverfew: chemistry and biological activity.
1995,
Pubmed
Lasko,
Translational control during early development.
2009,
Pubmed
,
Xenbase
Machaca,
Induction of maturation-promoting factor during Xenopus oocyte maturation uncouples Ca(2+) store depletion from store-operated Ca(2+) entry.
2002,
Pubmed
,
Xenbase
MacNicol,
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF.
1993,
Pubmed
,
Xenbase
MacNicol,
Developmental timing of mRNA translation--integration of distinct regulatory elements.
2010,
Pubmed
,
Xenbase
Nasim,
Melampomagnolide B: a new antileukemic sesquiterpene.
2011,
Pubmed
Nasim,
Antileukemic activity of aminoparthenolide analogs.
2008,
Pubmed
Nozaki,
Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.
2001,
Pubmed
Pei,
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
2013,
Pubmed
Peterson,
A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.
2001,
Pubmed
,
Xenbase
Schwab,
p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis.
1999,
Pubmed
,
Xenbase
Skalska,
Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.
2009,
Pubmed
Sweeney,
Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate.
2004,
Pubmed
Tomlinson,
Chemical genetics and drug discovery in Xenopus.
2012,
Pubmed
,
Xenbase
Verma,
Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.
2004,
Pubmed
,
Xenbase
Wen,
Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide.
2002,
Pubmed
Wheeler,
Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus.
2009,
Pubmed
,
Xenbase
Wheeler,
Xenopus: an ideal system for chemical genetics.
2012,
Pubmed
,
Xenbase
White,
DHODH modulates transcriptional elongation in the neural crest and melanoma.
2011,
Pubmed
Wignall,
Identification of a novel protein regulating microtubule stability through a chemical approach.
2004,
Pubmed
,
Xenbase
Woods,
Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments.
2011,
Pubmed
Yip-Schneider,
Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.
2005,
Pubmed
Zhang,
Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells.
2012,
Pubmed