Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.
Emery B
,
Agalliu D
,
Cahoy JD
,
Watkins TA
,
Dugas JC
,
Mulinyawe SB
,
Ibrahim A
,
Ligon KL
,
Rowitch DH
,
Barres BA
.
???displayArticle.abstract???
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination. Within the CNS, MRF is specifically expressed by postmitotic oligodendrocytes. MRF is a nuclear protein containing an evolutionarily conserved DNA binding domain homologous to a yeast transcription factor. Knockdown of MRF in oligodendrocytes by RNA interference prevents expression of most CNS myelin genes; conversely, overexpression of MRF within cultured oligodendrocyte progenitors or the chick spinal cord promotes expression of myelin genes. In mice lacking MRF within the oligodendrocyte lineage, premyelinating oligodendrocytes are generated but display severe deficits in myelin gene expression and fail to myelinate. These mice display severe neurological abnormalities and die because of seizures during the third postnatal week. These findings establish MRF as a critical transcriptional regulator essential for oligodendrocyte maturation and CNS myelination.
Arnett,
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
2004, Pubmed
Arnett,
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
2004,
Pubmed
Barres,
Cell death and control of cell survival in the oligodendrocyte lineage.
1992,
Pubmed
Cahoy,
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.
2008,
Pubmed
Dugas,
Functional genomic analysis of oligodendrocyte differentiation.
2006,
Pubmed
Farley,
Widespread recombinase expression using FLPeR (flipper) mice.
2000,
Pubmed
Fu,
Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation.
2002,
Pubmed
He,
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.
2007,
Pubmed
He,
The Yin and Yang of YY1 in the nervous system.
2008,
Pubmed
Jang,
In vivo detection of Egr2 binding to target genes during peripheral nerve myelination.
2006,
Pubmed
Kuhlbrodt,
Sox10, a novel transcriptional modulator in glial cells.
1998,
Pubmed
Lappe-Siefke,
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.
2003,
Pubmed
Li,
Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes.
2007,
Pubmed
Lu,
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.
2000,
Pubmed
Lu,
Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.
2002,
Pubmed
Montano,
Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast.
2002,
Pubmed
Nagarajan,
EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression.
2001,
Pubmed
Pakkasjärvi,
Indicative oligodendrocyte dysfunction in spinal cords of human fetuses suffering from a lethal motoneuron disease.
2005,
Pubmed
Qi,
Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor.
2001,
Pubmed
Schüller,
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
2008,
Pubmed
Southwood,
CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure.
2004,
Pubmed
Stöhr,
cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein.
2000,
Pubmed
Stolt,
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.
2002,
Pubmed
Topilko,
Krox-20 controls myelination in the peripheral nervous system.
1994,
Pubmed
Trapp,
Differentiation and death of premyelinating oligodendrocytes in developing rodent brain.
1997,
Pubmed
Xin,
Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice.
2005,
Pubmed
Zhou,
The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.
2001,
Pubmed
Zhou,
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.
2002,
Pubmed
