Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Environ Sci Pollut Res Int
2014 Mar 01;215:3582-91. doi: 10.1007/s11356-013-2323-4.
Show Gene links
Show Anatomy links
Toxicity of the azo dyes Acid Red 97 and Bismarck Brown Y to Western clawed frog (Silurana tropicalis).
Soriano JJ
,
Mathieu-Denoncourt J
,
Norman G
,
de Solla SR
,
Langlois VS
.
???displayArticle.abstract???
Azo compounds are used in a variety of industrial applications, such as textile colorant. Azo dyes have been found to contaminate aquatic environments and it has been shown that these compounds could potentially be toxic or induce endocrine disruption in aquatic organisms. However, there are few data available on the toxicity of these dyes, specifically Acid Red 97 (AR97) and Bismarck Brown Y (BBY). The aim of this study was to determine the toxicity and the endocrine-disrupting properties of AR97 and BBY in frogs. As fugacity modeling predicted that both compounds would sorb to sediment, sediment exposures were performed using a geometric range of concentrations (0, 1, 10, 100 and 1,000 ppm). Both AR97 and BBY dyes were not lethal to Silurana tropicalis embryos; however, BBY significantly induced malformations. Gene expression analysis of oxidative stress and mutagen-related genes was performed in BBY-treated larvae. There were significant two-fold increases of the tumor-suppressing protein p53 and heat shock protein 70 mRNA at 1,000 ppm suggesting that BBY induces cellular stress in early S. tropicalis development. Transcripts of the heat shock protein 90 did not change. Furthermore, reproductive-related genes were assessed and a 2.1-fold change was observed in the mRNA of the steroidogenic acute regulatory protein while steroid 5 alpha-reductase type 2 and androgen receptor transcript levels did not vary among treatments. In conclusion, high concentrations of BBY lead to increased developmental defects in frog embryogenesis and early larval development.
Altenburger,
Mixture toxicity and its modeling by quantitative structure-activity relationships.
2003, Pubmed
Altenburger,
Mixture toxicity and its modeling by quantitative structure-activity relationships.
2003,
Pubmed
Beckham,
Role of HSP70 in cellular thermotolerance.
2008,
Pubmed
Ben Mansour,
In vitro study of DNA damage induced by acid orange 52 and its biodegradation derivatives.
2009,
Pubmed
Berzins,
Bioaccumulation of lead in Xenopus laevis tadpoles from water and sediment.
2002,
Pubmed
,
Xenbase
Birhanli,
Evaluation of the toxicity and teratogenity of six commercial textile dyes using the frog embryo teratogenesis assay-Xenopus.
2005,
Pubmed
,
Xenbase
Chung,
The significance of azo-reduction in the mutagenesis and carcinogenesis of azo dyes.
1983,
Pubmed
Collier,
Reduction of azo dyes during in vitro percutaneous absorption.
1993,
Pubmed
de Aragão Umbuzeiro,
The contribution of azo dyes to the mutagenic activity of the Cristais River.
2005,
Pubmed
De Gendt,
Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice.
2012,
Pubmed
Dong,
Induction of p53-mediated apoptosis in splenocytes and thymocytes of C57BL/6 mice exposed to perfluorooctane sulfonate (PFOS).
2012,
Pubmed
Gao,
Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.
2011,
Pubmed
Giaccia,
The complexity of p53 modulation: emerging patterns from divergent signals.
1998,
Pubmed
Güngördü,
Biochemical response to exposure to six textile dyes in early developmental stages of Xenopus laevis.
2013,
Pubmed
,
Xenbase
Hallare,
Comparative embryotoxicity and proteotoxicity of three carrier solvents to zebrafish (Danio rerio) embryos.
2006,
Pubmed
Han,
The in vivo gene expression signature of oxidative stress.
2008,
Pubmed
Kumar,
Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system.
2008,
Pubmed
Langlois,
Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development.
2010,
Pubmed
,
Xenbase
Lehmann,
Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate.
2004,
Pubmed
Matwee,
The effects of antibodies to heat shock protein 70 in fertilization and embryo development.
2001,
Pubmed
Moallem,
The role of p53 and cell death by apoptosis and necrosis in 4-hydroperoxycyclophosphamide-induced limb malformations.
1998,
Pubmed
Mosser,
Molecular chaperones and the stress of oncogenesis.
2004,
Pubmed
Nakayama,
Generation of hydrogen peroxide and superoxide anion from active metabolites of naphthylamines and aminoazo dyes: its possible role in carcinogenesis.
1983,
Pubmed
Nelson,
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
1994,
Pubmed
Osugi,
Photoelectrocatalytic oxidation of remazol turquoise blue and toxicological assessment of its oxidation products.
2006,
Pubmed
Paden,
Expression of steroidogenic acute regulatory protein (StAR) in male American bullfrog (Rana catesbeiana) and preliminary evaluation of the response to TNT.
2010,
Pubmed
Papadopoulos,
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis.
1997,
Pubmed
Rupik,
Promoter of the heat shock testis-specific Hsp70.2/Hst70 gene is active in nervous system during embryonic development of mice.
2006,
Pubmed
Sánchez,
Steroid 5α-reductase in adult rat brain after neonatal dihydrotestosterone administration.
2013,
Pubmed
Sharma,
Identification of a sensitive index during fish bioassay of an azo dye methyl red (untreated and treated).
2006,
Pubmed
Suryavathi,
Acute toxicity of textile dye wastewaters (untreated and treated) of Sanganer on male reproductive systems of albino rats and mice.
2005,
Pubmed
Topaç,
Effect of a sulfonated azo dye and sulfanilic acid on nitrogen transformation processes in soil.
2009,
Pubmed
Weber,
Chemical- and sediment-mediated reduction of the azo dye disperse blue 79.
1995,
Pubmed
Zhou,
Chemical pollution and transport of organic dyes in water-soil-crop systems of the Chinese Coast.
2001,
Pubmed
