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XB-ART-5023
J Med Chem 2003 Jul 17;4615:3197-200. doi: 10.1021/jm034073f.
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(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.

Wu YJ , Boissard CG , Greco C , Gribkoff VK , Harden DG , He H , L'Heureux A , Kang SH , Kinney GG , Knox RJ , Natale J , Newton AE , Lehtinen-Oboma S , Sinz MW , Sivarao DV , Starrett JE , Sun LQ , Tertyshnikova S , Thompson MW , Weaver D , Wong HS , Zhang L , Dworetzky SI .


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(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.

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Species referenced: Xenopus laevis
Genes referenced: kcnq2