XB-ART-50234
Gene Expr Patterns
2015 Jan 01;171:38-44. doi: 10.1016/j.gep.2014.12.002.
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Characterization of tweety gene (ttyh1-3) expression in Xenopus laevis during embryonic development.
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The tweety family of genes encodes large-conductance chloride channels and has been implicated in a wide array of cellular processes including cell division, cell adhesion, regulation of calcium activity, and tumorigenesis, particularly in neuronal cells. However, their expression patterns during early development remain largely unknown. Here, we describe the spatial and temporal patterning of ttyh1, ttyh2, and ttyh3 in Xenopus laevis during early embryonic development. Ttyh1 and ttyh3 are initially expressed at the late neurula stage are and primarily localized to the developing nervous system; however ttyh1 and ttyh3 both show transient expression in the somites. By swimming tadpole stages, all three genes are expressed in the brain, spinal cord, eye, and cranial ganglia. While ttyh1 is restricted to proliferative, ventricular zones, ttyh3 is primarily localized to postmitotic regions of the developing nervous system. Ttyh2, however, is strongly expressed in cranial ganglia V, VII, IX and X. The differing temporal and spatial expression patterns of ttyh1, ttyh2, and ttyh3 suggest that they may play distinct roles throughout embryonic development.
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Species referenced: Xenopus laevis
Genes referenced: slc17a7 ttyh1 ttyh2 ttyh3
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References [+] :
Al-Jumaily,
Expression of three distinct families of calcium-activated chloride channel genes in the mouse dorsal root ganglion.
2007, Pubmed