XB-ART-50560
Development
2015 May 01;1429:1555-60. doi: 10.1242/dev.121590.
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Animal models for studying neural crest development: is the mouse different?
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The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we discuss these species-specific differences, suggest possible explanations for the divergent phenotypes in mouse and urge the community to consider these issues and the need for further research in complementary systems.
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HD037105 NICHD NIH HHS , MR/J000655/1 Medical Research Council , R01 DE016082 NIDCR NIH HHS, MR/M010465/1 Medical Research Council , DE024157 NIDCR NIH HHS, DE 016082 NIDCR NIH HHS, Wellcome Trust , MRC_MR/M010465/1 Medical Research Council , R01 DE024157 NIDCR NIH HHS, P01 HD037105 NICHD NIH HHS
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