Abousaab A , Warsi J , Elvira B , Alesutan I , Hoseinzadeh Z , Lang F .

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Alessi, The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. 2014, Pubmed
Almilaji, Regulation of the voltage gated K channel Kv1.3 by recombinant human klotho protein. 2014, Pubmed , Xenbase
Almilaji, Upregulation of the creatine transporter Slc6A8 by Klotho. 2014, Pubmed , Xenbase
Almilaji, Upregulation of Na+,Cl(-)-coupled betaine/γ-amino-butyric acid transporter BGT1 by Tau tubulin kinase 2. 2013, Pubmed , Xenbase
Almilaji, Down-regulation of Na/K+ atpase activity by human parvovirus B19 capsid protein VP1. 2013, Pubmed , Xenbase
Amara, Excitatory amino acid transporters: keeping up with glutamate. 2002, Pubmed
Barnett, Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function. 2000, Pubmed
Beart, Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. 2007, Pubmed
Ben-Ari, The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. 2012, Pubmed
Berger, Comparative analysis of glutamate transporter expression in rat brain using differential double in situ hybridization. 1998, Pubmed
Boehmer, Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. 2003, Pubmed , Xenbase
Boehmer, Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases. 2006, Pubmed , Xenbase
Boycott, Hypoxia suppresses astrocyte glutamate transport independently of amyloid formation. 2007, Pubmed
Capasso, Channels, carriers, and pumps in the pathogenesis of sodium-sensitive hypertension. 2005, Pubmed
Castañeda-Bueno, SPAKling insight into blood pressure regulation. 2010, Pubmed
Cholet, Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. 2002, Pubmed
Delpire, SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. 2008, Pubmed
Delpire, SPAK and OSR1, key kinases involved in the regulation of chloride transport. 2006, Pubmed
Dërmaku-Sopjani, Down-regulation of the Na+-coupled phosphate transporter NaPi-IIa by AMP-activated protein kinase. 2013, Pubmed , Xenbase
Derouiche, Coincidence of L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) immunoreactions in retinal glia: evidence for coupling of GLAST and GS in transmitter clearance. 1995, Pubmed
Desilva, Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia. 2008, Pubmed
Domercq, Expression of glutamate transporters in rat optic nerve oligodendrocytes. 1999, Pubmed
Domercq, Expression of glutamate transporters in the adult bovine corpus callosum. 1999, Pubmed
Elvira, SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1. 2014, Pubmed , Xenbase
Estrada Sánchez, Excitotoxic neuronal death and the pathogenesis of Huntington's disease. 2008, Pubmed
Falin, Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel. 2009, Pubmed
Falin, C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling. 2011, Pubmed
Fezai, Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1. 2014, Pubmed , Xenbase
Flatman, Cotransporters, WNKs and hypertension: an update. 2008, Pubmed , Xenbase
Foran, Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. 2009, Pubmed
Fukaya, Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella. 1999, Pubmed
Furgeson, Mechanisms of type I and type II pseudohypoaldosteronism. 2010, Pubmed
Furness, Immunocytochemical localization of a high-affinity glutamate-aspartate transporter, GLAST, in the rat and guinea-pig cochlea. 1997, Pubmed
Gagnon, On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity. 2010, Pubmed , Xenbase
Gagnon, Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport. 2012, Pubmed
Gaillet, Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture. 2001, Pubmed
Gehring, Regulation of the glutamate transporter EAAT2 by PIKfyve. 2009, Pubmed , Xenbase
Gibb, A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. 2007, Pubmed
Giménez, Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters. 2006, Pubmed
Glover, SPAK and WNK kinases: a new target for blood pressure treatment? 2011, Pubmed
Glover, Hypertension, dietary salt intake, and the role of the thiazide-sensitive sodium chloride transporter NCCT. 2011, Pubmed
Gray, Glutamate does not play a major role in controlling bone growth. 2001, Pubmed
Hoffmann, Physiology of cell volume regulation in vertebrates. 2009, Pubmed
Hoffmann, Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells. 2011, Pubmed
Hosseinzadeh, Down-regulation of the epithelial Na⁺ channel ENaC by Janus kinase 2. 2014, Pubmed , Xenbase
Hosseinzadeh, Upregulation of peptide transporters PEPT1 and PEPT2 by Janus kinase JAK2. 2013, Pubmed , Xenbase
Hosseinzadeh, Downregulation of KCNQ4 by Janus kinase 2. 2013, Pubmed , Xenbase
Huang, Mechanism of regulation of renal ion transport by WNK kinases. 2008, Pubmed
Huggett, The open reading frame of the Na(+)-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. 2000, Pubmed
Hurtado, Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke. 2008, Pubmed
Kahle, Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. 2010, Pubmed
Karlsson, Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist. 2008, Pubmed
Karlsson, Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia. 2009, Pubmed
Kimmich, Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1. 2001, Pubmed
Lang, Mechanisms and significance of cell volume regulation. 2007, Pubmed
Lang, Molecular mechanisms of schizophrenia. 2007, Pubmed
Lawton, Localization of the glutamate-aspartate transporter, GLAST, in rat taste buds. 2000, Pubmed
Lee, Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands. 2001, Pubmed
Lehre, The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. 1998, Pubmed
Li, Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression. 1997, Pubmed
Li, Identification of a glutamate/aspartate transporter in the rat cochlea. 1994, Pubmed
Lin, Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. 2011, Pubmed
Markowitz, Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration. 2007, Pubmed
Mason, Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents? 1997, Pubmed
Matsumoto, The -181 A/C polymorphism in the excitatory amino acid transporter-2 gene promoter affects the personality trait of reward dependence in healthy subjects. 2007, Pubmed
Mercier-Zuber, Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters. 2011, Pubmed
Milton, Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study. 1997, Pubmed
Miyazaki, Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation. 2012, Pubmed
Münch, Chemical hypoxia facilitates alternative splicing of EAAT2 in presymptomatic APP23 transgenic mice. 2008, Pubmed
Munoz, Up-regulation of the inwardly rectifying K⁺ channel Kir2.1 (KCNJ2) by protein kinase B (PKB/Akt) and PIKfyve. 2013, Pubmed , Xenbase
Nomura, Molecular events caused by mechanical stress in bone. 2000, Pubmed
O'Reilly, WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. 2003, Pubmed
Pakladok, PIKfyve sensitivity of hERG channels. 2013, Pubmed , Xenbase
Pampliega, Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple sclerosis. 2008, Pubmed
Park, Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion. 2010, Pubmed
Pathare, OSR1-sensitive renal tubular phosphate reabsorption. 2012, Pubmed , Xenbase
Plachez, Transient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture. 2000, Pubmed
Rafiqi, Role of the WNK-activated SPAK kinase in regulating blood pressure. 2010, Pubmed
Rakhade, Focal reduction of neuronal glutamate transporters in human neocortical epilepsy. 2008, Pubmed
Rakhade, Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy. 2007, Pubmed
Redecker, Immunohistochemical study of the glutamate transporter proteins GLT-1 and GLAST in rat and gerbil pineal gland. 2000, Pubmed
Richardson, Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. 2011, Pubmed
Richardson, The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. 2008, Pubmed
Rothstein, Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. 1995, Pubmed
Rothstein, Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. 1992, Pubmed
Rothstein, Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. 1996, Pubmed
Rothstein, Localization of neuronal and glial glutamate transporters. 1994, Pubmed
Rothstein, Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. 2005, Pubmed
Rumbaugh, Ceftriaxone protects against the neurotoxicity of human immunodeficiency virus proteins. 2007, Pubmed
Sandhu, Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells. 2002, Pubmed
Sheldon, The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. 2007, Pubmed
Shigeri, Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). 2001, Pubmed , Xenbase
Suárez, Modulation of glutamate transporters (GLAST, GLT-1 and EAAC1) in the rat cerebellum following portocaval anastomosis. 2000, Pubmed
Suzuki, Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor, insulin-like growth factor and epidermal growth factor in cultured astrocytes. 2001, Pubmed
Takumi, Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organ. 1997, Pubmed
Tanaka, Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. 1997, Pubmed
Tian, Translational control of glial glutamate transporter EAAT2 expression. 2007, Pubmed
Uchida, Pathophysiological roles of WNK kinases in the kidney. 2010, Pubmed
Ullensvang, Differential developmental expression of the two rat brain glutamate transporter proteins GLAST and GLT. 1997, Pubmed
Utsumi, Differential expression patterns of three glutamate transporters (GLAST, GLT1 and EAAC1) in the rat main olfactory bulb. 2001, Pubmed
van Landeghem, Decreased expression of glutamate transporters in astrocytes after human traumatic brain injury. 2006, Pubmed
Vercellino, Altered glutamate reuptake in relapsing-remitting and secondary progressive multiple sclerosis cortex: correlation with microglia infiltration, demyelination, and neuronal and synaptic damage. 2007, Pubmed
Villa, Structure of the OSR1 kinase, a hypertension drug target. 2008, Pubmed
Vitari, The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. 2005, Pubmed
Vitari, Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. 2006, Pubmed
Vorwerk, Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. 2000, Pubmed
Warsi, Regulation of ClC-2 activity by SPAK and OSR1. 2014, Pubmed , Xenbase
Warsi, SPAK dependent regulation of peptide transporters PEPT1 and PEPT2. 2014, Pubmed , Xenbase
Warsi, Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1. 2014, Pubmed , Xenbase
Wilson, Human hypertension caused by mutations in WNK kinases. 2001, Pubmed
Yang, SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. 2010, Pubmed
Yang, STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. 2013, Pubmed