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This review addresses the developmental roles of 2 GTPases of the Rho family, RhoV/Chp and RhoU/Wrch. These two GTPases form a distinct subfamily related to Rac and Cdc42 proteins and were detected in a screen for Rho members that are particularly expressed in the neural crest, an embryonic tissue peculiar to vertebrates. The neural crest represents a physiological model of normal epithelial to mesenchymal transition (EMT), in which epithelial cells at the border of neural and non-neural ectoderm differentiate, lose their intercellular connections and migrate throughout the embryo. We showed that RhoV, transiently induced by the canonical Wnt pathway, is required for the full differentiation of neural crest cells, while RhoU, induced later by the non-canonical Wnt pathway, is necessary for the migration process. These two GTPases, which are highly conserved across vertebrates, are thus tightly functionally linked to Wnt signaling, whose implication in embryonic development and cancer progression is well established. In the light of the recent literature, we discuss how RhoV and RhoU may achieve their physiological functions.
Alan,
Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.
2010, Pubmed
Alan,
Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.
2010,
Pubmed
Aspenström,
Rho GTPases have diverse effects on the organization of the actin filament system.
2004,
Pubmed
Aspenström,
Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases.
2007,
Pubmed
Aybar,
Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest.
2003,
Pubmed
,
Xenbase
Betancur,
Assembling neural crest regulatory circuits into a gene regulatory network.
2010,
Pubmed
Block,
Pyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cells.
2010,
Pubmed
Boureux,
Evolution of the Rho family of ras-like GTPases in eukaryotes.
2007,
Pubmed
,
Xenbase
Brady,
The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis.
2009,
Pubmed
Broders-Bondon,
Regulation of XSnail2 expression by Rho GTPases.
2007,
Pubmed
,
Xenbase
Budi,
Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation.
2008,
Pubmed
Chenette,
Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase.
2005,
Pubmed
Chuang,
The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration.
2007,
Pubmed
Davidson,
Neural tube closure in Xenopus laevis involves medial migration, directed protrusive activity, cell intercalation and convergent extension.
1999,
Pubmed
,
Xenbase
De Calisto,
Essential role of non-canonical Wnt signalling in neural crest migration.
2005,
Pubmed
,
Xenbase
Fort,
Activity of the RhoU/Wrch1 GTPase is critical for cranial neural crest cell migration.
2011,
Pubmed
,
Xenbase
Fuchs,
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.
2009,
Pubmed
Guémar,
The small GTPase RhoV is an essential regulator of neural crest induction in Xenopus.
2007,
Pubmed
,
Xenbase
Huang,
Induction of the neural crest and the opportunities of life on the edge.
2004,
Pubmed
,
Xenbase
Katoh,
Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells.
2011,
Pubmed
Le Douarin,
Multipotentiality of the neural crest.
2003,
Pubmed
Lee,
Requirement for neuregulin receptor erbB2 in neural and cardiac development.
1995,
Pubmed
Liu,
A role for rhoB in the delamination of neural crest cells from the dorsal neural tube.
1998,
Pubmed
Matthews,
Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.
2008,
Pubmed
,
Xenbase
Murphy,
A Src-Tks5 pathway is required for neural crest cell migration during embryonic development.
2011,
Pubmed
Ory,
Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration.
2007,
Pubmed
Ruusala,
The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics.
2008,
Pubmed
Saras,
Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects.
2004,
Pubmed
Saxton,
Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis.
2001,
Pubmed
Schiavone,
The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways.
2009,
Pubmed
Schlessinger,
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity.
2007,
Pubmed
Schlessinger,
Wnt signaling pathways meet Rho GTPases.
2009,
Pubmed
,
Xenbase
Shutes,
Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.
2004,
Pubmed
Takebe,
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways.
2011,
Pubmed
Tao,
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.
2001,
Pubmed
Tay,
A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly.
2010,
Pubmed
Theveneau,
Integrating chemotaxis and contact-inhibition during collective cell migration: Small GTPases at work.
2010,
Pubmed
Thiery,
Epithelial-mesenchymal transitions in development and disease.
2009,
Pubmed
Thomas,
Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations.
2010,
Pubmed
Weisz Hubsman,
Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.
2007,
Pubmed
Whale,
Signalling to cancer cell invasion through PAK family kinases.
2011,
Pubmed
Yang,
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.
2005,
Pubmed
Zhang,
GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.
2011,
Pubmed
