Babiker T , Vedovato N , Patel K , Thomas N , Finn R , Männikkö R , Chakera AJ , Flanagan SE , Shepherd MH , Ellard S , Ashcroft FM , Hattersley AT .

Wellcome Trust , PDA/02/06/098 Department of Health

             regulation of insulin secretion

Fig. 1. Sulfonylurea block of wild-type and mutant KATP channels. Percentage inhibition of whole-cell KATP channel currents in wild-type (WT) and mutant (as indicated) channels in response to 0.5 mmol/l tolbutamide. Current in the presence of tolbutamide is expressed as a percentage of that in the absence of drug [2, 9, 11–14]. The numbers in parenthesis indicate the number of patients who responded to sulfonylureas (left) out of the total number (right) with the indicated mutation. White bars, all patients responded; grey bars, some patients responded; black bars, no patients responded. The vertical light grey bar indicates the level of block that separates those patients who responded from those who did not

Fig. 2. The younger the patients are (i.e. the shorter the duration of diabetes), the greater the likelihood of a successful transfer. Only KCNJ11 mutations for which some patients transfer and others do not (p.R201H, p.R201C, p.V59M, p.G334C, p.G53S, p.Q52R) are shown. White bars, successful transfer; black bars, unsuccessful transfer

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