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Triclosan (TCS) is commonly used worldwide in a range of personal care and sanitizing products. The aim of this study was to evaluate potential effects of TCS exposure on embryonic development of Bufo gargarizans, an endemic frog species in China. Standard Gosner stage 3 B. gargarizans embryos were exposed to 10 ~ 150 μg/L TCS during embryogenesis. Survival, total length, weight, developmental stage, duration of different embryo stages, malformation, and type II and III deiodinase (D2 and D3) expression were measured. Inhibitory effects on embryo developmental stage, total length and weight were found at 30 ~ 150 μg/L TCS. Moreover, the duration of embryonic development was increased at gastrula, neural, circulation, and operculum development stage in TCS-treated groups. In addition, TCS exposure induced morphological malformations in B. gargarizans embryos, which are characterized by hyperplasia, abdominal edema, and axial flexures. Furthermore, our results showed that the expression of D2 in embryos was probably down-regulated at 60 and 150 μg/L TCS, but its spatial expression patterns was not affected by TCS. In summary, our study suggested that TCS exposure not only resulted in delayed growth and development but also caused teratogenic effects in B. gargarizans embryos, and the developmental effects of TCS at high concentrations may be associated with disruption of THs homeostasis. Although further studies are necessary, the present findings could provide a basis for understanding on harmful effects and the potential mechanisms of TCS in amphibian embryos.
Aronzon,
Differential toxicity and uptake of Diazinon on embryo-larval development of Rhinella arenarum.
2014, Pubmed
Aronzon,
Differential toxicity and uptake of Diazinon on embryo-larval development of Rhinella arenarum.
2014,
Pubmed
Binelli,
Cytotoxic and genotoxic effects of in vitro exposure to triclosan and trimethoprim on zebra mussel (Dreissena polymorpha) hemocytes.
2009,
Pubmed
Binelli,
In vivo experiments for the evaluation of genotoxic and cytotoxic effects of Triclosan in Zebra mussel hemocytes.
2009,
Pubmed
Bonett,
Molecular mechanisms of corticosteroid synergy with thyroid hormone during tadpole metamorphosis.
2010,
Pubmed
,
Xenbase
Bonfanti,
Comparative teratogenicity of chlorpyrifos and malathion on Xenopus laevis development.
2004,
Pubmed
,
Xenbase
Edginton,
2,4-D butoxyethyl ester kinetics in embryos of Xenopus laevis: the role of the embryonic jelly coat in reducing chemical absorption.
2007,
Pubmed
,
Xenbase
Fini,
Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption.
2012,
Pubmed
,
Xenbase
Foran,
Developmental evaluation of a potential non-steroidal estrogen: triclosan.
2000,
Pubmed
Fort,
The hypothalamic-pituitary-thyroid (HPT) axis in frogs and its role in frog development and reproduction.
2007,
Pubmed
,
Xenbase
Fort,
Triclosan and thyroid-mediated metamorphosis in anurans: differentiating growth effects from thyroid-driven metamorphosis in Xenopus laevis.
2011,
Pubmed
,
Xenbase
Galton,
The role of 3,5,3'-triiodothyronine in the physiological action of thyroxine in the premetamorphic tadpole.
1989,
Pubmed
Heijlen,
Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish.
2014,
Pubmed
Helbing,
Triclosan affects thyroid hormone-dependent metamorphosis in anurans.
2011,
Pubmed
,
Xenbase
Hutler Wolkowicz,
Lethal and sublethal toxicity of the industrial chemical epichlorohydrin on Rhinella arenarum (Anura, Bufonidae) embryos and larvae.
2013,
Pubmed
Ishibashi,
Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin.
2004,
Pubmed
Kuiper,
Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil.
2006,
Pubmed
,
Xenbase
Levy,
Molecular basis of triclosan activity.
1999,
Pubmed
Li,
Toxic effects of 1-methyl-3-octylimidazolium bromide on the early embryonic development of the frog Rana nigromaculata.
2009,
Pubmed
Liu,
Thyroid hormones are important for embryonic to larval transitory phase in zebrafish.
2002,
Pubmed
Marlatt,
Triclosan exposure alters postembryonic development in a Pacific tree frog (Pseudacris regilla) Amphibian Metamorphosis Assay (TREEMA).
2013,
Pubmed
,
Xenbase
McArthur,
Antimicrobial textiles.
2012,
Pubmed
Monsoro-Burq,
A rapid protocol for whole-mount in situ hybridization on Xenopus embryos.
2007,
Pubmed
,
Xenbase
Møretrø,
Assessment of the antibacterial activity of a triclosan-containing cutting board.
2011,
Pubmed
Morvan Dubois,
Deiodinase activity is present in Xenopus laevis during early embryogenesis.
2006,
Pubmed
,
Xenbase
Mukhi,
Effects of prolonged exposure to perchlorate on thyroid and reproductive function in zebrafish.
2007,
Pubmed
Nakada,
Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage.
2008,
Pubmed
Nassef,
In ovo nanoinjection of triclosan, diclofenac and carbamazepine affects embryonic development of medaka fish (Oryzias latipes).
2010,
Pubmed
Newton,
Effect of triclosan (TRN) on energy-linked functions of rat liver mitochondria.
2005,
Pubmed
Oliveira,
Effects of triclosan on zebrafish early-life stages and adults.
2009,
Pubmed
Orvos,
Aquatic toxicity of triclosan.
2002,
Pubmed
Piccoli,
Determination of triclosan in personal health care products by liquid chromatography (HPLC).
2002,
Pubmed
Ramaswamy,
GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers.
2011,
Pubmed
Salin,
Alteration of mitochondrial efficiency affects oxidative balance, development and growth in frog (Rana temporaria) tadpoles.
2012,
Pubmed
Schultz,
Effects of triclosan and triclocarban, two ubiquitous environmental contaminants, on anatomy, physiology, and behavior of the fathead minnow (Pimephales promelas).
2012,
Pubmed
Singh,
Occurrence and distribution of steroids, hormones and selected pharmaceuticals in South Florida coastal environments.
2010,
Pubmed
Sone,
Effects of 17beta-estradiol, nonylphenol, and bisphenol-A on developing Xenopus laevis embryos.
2004,
Pubmed
,
Xenbase
Tindall,
Expression of enzymes involved in thyroid hormone metabolism during the early development of Xenopus tropicalis.
2007,
Pubmed
,
Xenbase
Veldhoen,
The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development.
2006,
Pubmed
,
Xenbase
Walpita,
Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish.
2009,
Pubmed
Weber,
Changes in whole-body thyroxine and triiodothyronine concentrations and total content during early development and metamorphosis of the toad Bufo marinus.
1994,
Pubmed
Xia,
Chronic toxicity of copper on embryo development in Chinese toad, Bufo gargarizans.
2012,
Pubmed
Yueh,
The commonly used antimicrobial additive triclosan is a liver tumor promoter.
2014,
Pubmed
Zhang,
Multimedia modeling of the fate of triclosan and triclocarban in the Dongjiang River Basin, South China and comparison with field data.
2013,
Pubmed
Zhao,
Effects of fluoride on metamorphosis, thyroid and skeletal development in Bufo gargarizans tadpoles.
2013,
Pubmed
