XB-ART-53027
Genesis
2017 Jan 01;551-2:. doi: 10.1002/dvg.23007.
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Maternal messages to live by: a personal historical perspective.
King ML
.
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In the 1980s, the study of localized maternal mRNAs was just emerging as a new research area. Classic embryological studies had linked the inheritance of cytoplasmic domains with specific cell lineages, but the underlying molecular nature of these putative determinants remained a mystery. The model system Xenopus would play a pivotal role in the progress of this new field. In fact, the first localized maternal mRNA to be identified and cloned from any organism was Xenopus vg1, a TGF-beta family member. This seminal finding opened the door to many subsequent studies focused on how RNAs are localized and what functions they had in development. As the field moves into the future, Xenopus remains the system of choice for studies identifying RNA/protein transport particles and maternal RNAs through RNA-sequencing.
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Species referenced: Xenopus laevis
Genes referenced: gdf1
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References [+] :
Ahmad,
RNA-SSPT: RNA Secondary Structure Prediction Tools.
2013, Pubmed
Ahmad, RNA-SSPT: RNA Secondary Structure Prediction Tools. 2013, Pubmed
Alarcón, RNA anchoring in the vegetal cortex of the Xenopus oocyte. 2001, Pubmed , Xenbase
Birsoy, XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development. 2005, Pubmed , Xenbase
BLACKLER, Contribution to the study of germ-cells in the anura. 1958, Pubmed
Blitz, Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system. 2013, Pubmed , Xenbase
Briggs, Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs. 1952, Pubmed
BRIGGS, Nuclear transplantation studies on the early gastrula (Rana pipiens). I. Nuclei of presumptive endoderm. 1960, Pubmed
Bruce, The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation. 2003, Pubmed , Xenbase
Bubunenko, A consensus RNA signal that directs germ layer determinants to the vegetal cortex of Xenopus oocytes. 2002, Pubmed , Xenbase
Chan, fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes. 1999, Pubmed , Xenbase
Chang, Localization of RNAs to the mitochondrial cloud in Xenopus oocytes through entrapment and association with endoplasmic reticulum. 2004, Pubmed , Xenbase
Claussen, Functional dissection of the RNA signal sequence responsible for vegetal localization of XGrip2.1 mRNA in Xenopus oocytes. 2011, Pubmed , Xenbase
Claußen, Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species. 2015, Pubmed , Xenbase
Colozza, Maternal syntabulin is required for dorsal axis formation and is a germ plasm component in Xenopus. 2014, Pubmed , Xenbase
Cote, A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization. 1999, Pubmed , Xenbase
Cui, Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis. 1995, Pubmed , Xenbase
Cuykendall, Identification of germ plasm-associated transcripts by microarray analysis of Xenopus vegetal cortex RNA. 2010, Pubmed , Xenbase
De Domenico, Molecular asymmetry in the 8-cell stage Xenopus tropicalis embryo described by single blastomere transcript sequencing. 2015, Pubmed , Xenbase
Deshler, Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum. 1997, Pubmed , Xenbase
Elinson, A transient array of parallel microtubules in frog eggs: potential tracks for a cytoplasmic rotation that specifies the dorso-ventral axis. 1988, Pubmed , Xenbase
Elinson, Isolated vegetal cortex from Xenopus oocytes selectively retains localized mRNAs. 1993, Pubmed , Xenbase
Forristall, Patterns of localization and cytoskeletal association of two vegetally localized RNAs, Vg1 and Xcat-2. 1995, Pubmed , Xenbase
Gagnon, Directional transport is mediated by a Dynein-dependent step in an RNA localization pathway. 2013, Pubmed , Xenbase
Ge, Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. 2014, Pubmed , Xenbase
Grant, The amphibian gray crescent region--a site of developmental information? 1972, Pubmed
Gurdon, The translation of mammalian globin mRNA injected into fertilized eggs of Xenopus laevis I. Message stability in development. 1974, Pubmed , Xenbase
Gurdon, "Fertile" intestine nuclei. 1966, Pubmed
Gurdon, The future of cloning. 1999, Pubmed
Heasman, Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. 1994, Pubmed , Xenbase
Heasman, Vegetal localization of maternal mRNAs is disrupted by VegT depletion. 2001, Pubmed , Xenbase
Horb, A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation. 1997, Pubmed , Xenbase
Houston, A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule. 1998, Pubmed , Xenbase
Houston, Cortical rotation and messenger RNA localization in Xenopus axis formation. 2012, Pubmed , Xenbase
Houston, Regulation of cell polarity and RNA localization in vertebrate oocytes. 2013, Pubmed , Xenbase
Houston, A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus. 2000, Pubmed , Xenbase
Hudson, Xpat, a gene expressed specifically in germ plasm and primordial germ cells of Xenopus laevis. 1998, Pubmed , Xenbase
Jeffery, A yellow crescent cytoskeletal domain in ascidian eggs and its role in early development. 1983, Pubmed
Kaneshiro, The mRNA coding for Xenopus glutamate receptor interacting protein 2 (XGRIP2) is maternally transcribed, transported through the late pathway and localized to the germ plasm. 2007, Pubmed , Xenbase
Kirilenko, The efficiency of Xenopus primordial germ cell migration depends on the germplasm mRNA encoding the PDZ domain protein Grip2. 2008, Pubmed , Xenbase
Kloc, Binary function of mRNA. 2011, Pubmed , Xenbase
Kloc, Structural messenger RNA contains cytokeratin polymerization and depolymerization signals. 2011, Pubmed , Xenbase
Kloc, Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopus oocytes. 1995, Pubmed , Xenbase
Kloc, Organization of cytokeratin cytoskeleton and germ plasm in the vegetal cortex of Xenopus laevis oocytes depends on coding and non-coding RNAs: three-dimensional and ultrastructural analysis. 2007, Pubmed , Xenbase
Kloc, Three-dimensional ultrastructural analysis of RNA distribution within germinal granules of Xenopus. 2002, Pubmed , Xenbase
Kloc, Contribution of METRO pathway localized molecules to the organization of the germ cell lineage. 1998, Pubmed , Xenbase
Kloc, Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA. 1994, Pubmed , Xenbase
Kloc, The targeting of Xcat2 mRNA to the germinal granules depends on a cis-acting germinal granule localization element within the 3'UTR. 2000, Pubmed , Xenbase
Kloc, Translocation of repetitive RNA sequences with the germ plasm in Xenopus oocytes. 1993, Pubmed , Xenbase
Kloc, Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex of Xenopus oocytes. 2005, Pubmed , Xenbase
Koebernick, Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma. 2010, Pubmed , Xenbase
Kress, Nuclear RNP complex assembly initiates cytoplasmic RNA localization. 2004, Pubmed , Xenbase
Krieg, Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs. 1985, Pubmed , Xenbase
Ku, Xwnt-11: a maternally expressed Xenopus wnt gene. 1993, Pubmed , Xenbase
Lewis, PTB/hnRNP I is required for RNP remodeling during RNA localization in Xenopus oocytes. 2008, Pubmed , Xenbase
Lustig, Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. 1996, Pubmed , Xenbase
MacArthur, Xcat2 RNA is a translationally sequestered germ plasm component in Xenopus. 1999, Pubmed , Xenbase
MacArthur, DEADSouth is a germ plasm specific DEAD-box RNA helicase in Xenopus related to eIF4A. 2000, Pubmed , Xenbase
Machado, Xenopus Xpat protein is a major component of germ plasm and may function in its organisation and positioning. 2005, Pubmed , Xenbase
McMahon, Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. 1989, Pubmed , Xenbase
Melton, Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes. , Pubmed , Xenbase
Messitt, Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes. 2008, Pubmed , Xenbase
Mosquera, A mRNA localized to the vegetal cortex of Xenopus oocytes encodes a protein with a nanos-like zinc finger domain. 1993, Pubmed , Xenbase
Mowry, Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes. 1992, Pubmed , Xenbase
Nakayama, Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis. 2013, Pubmed , Xenbase
Newport, A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. 1982, Pubmed , Xenbase
Nieuwkoop, Origin and establishment of embryonic polar axes in amphibian development. 1977, Pubmed
Owens, High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration. 2017, Pubmed , Xenbase
Pondel, Localized maternal mRNA related to transforming growth factor beta mRNA is concentrated in a cytokeratin-enriched fraction from Xenopus oocytes. 1988, Pubmed , Xenbase
Ray, A compendium of RNA-binding motifs for decoding gene regulation. 2013, Pubmed
Rebagliati, Identification and cloning of localized maternal RNAs from Xenopus eggs. 1985, Pubmed , Xenbase
Richter, Interspersed poly(A) RNAs of amphibian oocytes are not translatable. 1984, Pubmed , Xenbase
Rowning, Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs. 1997, Pubmed , Xenbase
Scharf, Determination of the dorsal-ventral axis in eggs of Xenopus laevis: complete rescue of uv-impaired eggs by oblique orientation before first cleavage. 1980, Pubmed , Xenbase
Schröder, Super-resolution biomolecular crystallography with low-resolution data. 2010, Pubmed
Smith, Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center. 1991, Pubmed , Xenbase
Smith, The role of a "germinal plasm" in the formation of primordial germ cells in Rana pipiens. 1966, Pubmed
Sokol, Injected Wnt RNA induces a complete body axis in Xenopus embryos. 1991, Pubmed , Xenbase
Stennard, The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation. 1996, Pubmed , Xenbase
Summerton, Morpholino antisense oligomers: design, preparation, and properties. 1997, Pubmed , Xenbase
Tan, GRIP1 is required for homeostatic regulation of AMPAR trafficking. 2015, Pubmed
Tao, Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. 2005, Pubmed , Xenbase
Tarbashevich, XGRIP2.1 is encoded by a vegetally localizing, maternal mRNA and functions in germ cell development and anteroposterior PGC positioning in Xenopus laevis. 2007, Pubmed , Xenbase
Torpey, Function of maternal cytokeratin in Xenopus development. 1992, Pubmed , Xenbase
Venkataraman, PCR-based cloning and differential screening of RNAs from Xenopus primordial germ cells: cloning uniquely expressed RNAs from rare cells. 2004, Pubmed , Xenbase
Wang, Activity of long-chain acyl-CoA synthetase is required for maintaining meiotic arrest in Xenopus laevis. 2012, Pubmed , Xenbase
Weaver, Move it or lose it: axis specification in Xenopus. 2004, Pubmed , Xenbase
Weeks, A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. 1987, Pubmed , Xenbase
Woodland, The translation of mammalian globin mRNA injected into fertilized eggs of Xenopus laevis. II. The distribution of globin synthesis in different tissues. 1974, Pubmed , Xenbase
Yisraeli, A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. 1990, Pubmed , Xenbase
Yisraeli, The material mRNA Vg1 is correctly localized following injection into Xenopus oocytes. 1988, Pubmed , Xenbase
Zearfoss, Hermes is a localized factor regulating cleavage of vegetal blastomeres in Xenopus laevis. 2004, Pubmed , Xenbase
Zhang, Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning. 1996, Pubmed , Xenbase
Zhang, The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. 1998, Pubmed , Xenbase
Zhou, RNA transport to the vegetal cortex of Xenopus oocytes. 1996, Pubmed , Xenbase
Zhou, Xenopus autosomal recessive hypercholesterolemia protein couples lipoprotein receptors with the AP-2 complex in oocytes and embryos and is required for vitellogenesis. 2003, Pubmed , Xenbase
Zhou, Polarized distribution of mRNAs encoding a putative LDL receptor adaptor protein, xARH (autosomal recessive hypercholesterolemia) in Xenopus oocytes. 2004, Pubmed , Xenbase
Zhou, Localization of Xcat-2 RNA, a putative germ plasm component, to the mitochondrial cloud in Xenopus stage I oocytes. 1996, Pubmed , Xenbase