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Since their initial discovery, the intriguing proteins of the +TIP network have been the focus of intense investigation. Although many of the individual +TIP functions have been revealed, the capacity for +TIP proteins to regulate each other has not been widely addressed. Importantly, recent studies involving EBs, the master regulators of the +TIP complex, and several TOG-domain proteins have uncovered a novel mechanism of mutual +TIP regulation: allosteric interactions through changes in microtubule structure. These findings have added another level of complexity to the existing evidence on +TIP regulation and highlight the cooperative nature of the +TIP protein network.
Akhmanova,
Tracking the ends: a dynamic protein network controls the fate of microtubule tips.
2008, Pubmed
Akhmanova,
Tracking the ends: a dynamic protein network controls the fate of microtubule tips.
2008,
Pubmed
Al-Bassam,
Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.
2011,
Pubmed
,
Xenbase
Al-Bassam,
CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.
2010,
Pubmed
Alushin,
High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis.
2014,
Pubmed
Ayaz,
A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase.
2012,
Pubmed
Bieling,
Reconstitution of a microtubule plus-end tracking system in vitro.
2007,
Pubmed
Brouhard,
XMAP215 is a processive microtubule polymerase.
2008,
Pubmed
,
Xenbase
Buey,
Sequence determinants of a microtubule tip localization signal (MtLS).
2012,
Pubmed
Desai,
Microtubule polymerization dynamics.
1997,
Pubmed
des Georges,
Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice.
2008,
Pubmed
Elie-Caille,
Straight GDP-tubulin protofilaments form in the presence of taxol.
2007,
Pubmed
Fan,
Microtubule minus ends can be labelled with a phage display antibody specific to alpha-tubulin.
1996,
Pubmed
Grimaldi,
CLASPs are required for proper microtubule localization of end-binding proteins.
2014,
Pubmed
Honnappa,
An EB1-binding motif acts as a microtubule tip localization signal.
2009,
Pubmed
Honnappa,
Key interaction modes of dynamic +TIP networks.
2006,
Pubmed
Jiang,
A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins.
2012,
Pubmed
Leano,
A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation.
2013,
Pubmed
Maurer,
GTPgammaS microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs).
2011,
Pubmed
Maurer,
EBs recognize a nucleotide-dependent structural cap at growing microtubule ends.
2012,
Pubmed
Maurer,
EB1 accelerates two conformational transitions important for microtubule maturation and dynamics.
2014,
Pubmed
McEwen,
Evidence for a mixed lattice in microtubules reassembled in vitro.
1980,
Pubmed
Mitchison,
Localization of an exchangeable GTP binding site at the plus end of microtubules.
1993,
Pubmed
Mitchison,
Dynamic instability of microtubule growth.
,
Pubmed
Mitchison,
Microtubule assembly nucleated by isolated centrosomes.
,
Pubmed
Montenegro Gouveia,
In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends.
2010,
Pubmed
Nakamura,
Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells.
2012,
Pubmed
Vitre,
EB1 regulates microtubule dynamics and tubulin sheet closure in vitro.
2008,
Pubmed
Wade,
Cryoelectron microscopy of microtubules.
1993,
Pubmed
Walker,
Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.
1988,
Pubmed
Zanic,
Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels.
2013,
Pubmed
Zanic,
EB1 recognizes the nucleotide state of tubulin in the microtubule lattice.
2009,
Pubmed
