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XB-ART-53511
Rouxs Arch Dev Biol 1996 Feb 01;2055-6:282-289. doi: 10.1007/BF00365806.
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Heart formative factor(s) is localized in the anterior endoderm of early Xenopus neurula.

Tonegawa A , Moriya M , Tada M , Nishimatsu S , Katagiri C , Ueno N .


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To elucidate the mechanisms of early heart morphogenesis in Xenopus laevis, we examined the effect of endoderm on heart morphogenesis in the early Xenopus neurula. Explants of anterior ventral (presumptive heart) mesoderm from early neurula were cultured alone or in combination with endoderm dissected from various regions. Heart formation was scored by an original heart index based on morphology. These explant studies revealed that anterior ventral endoderm plays a critical role in heart morphogenesis. Furthermore, we found that it was possible to confer this heart-forming ability on posterior ventral endoderm by the injection of poly(A)+ RNA from stage 13 anterior endoderm. These results imply that the heart formative factor(s) is localized in the anterior endoderm of the early neurula and that at least part of this activity is encoded by mRNA(s).

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References [+] :
Dale, Fate map for the 32-cell stage of Xenopus laevis. 1987, Pubmed, Xenbase