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XB-ART-53565
Rouxs Arch Dev Biol 1987 Apr 01;1964:203-209. doi: 10.1007/BF00376344.
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Binding of anti-fibronectin to early amphibian ectoderm does not result in inhibition of neural induction under in vitro conditions.



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Antibodies directed to fibronectin (anti-FN) were injected into the blastocoel of late blastulae of Xenopus laevis. Two animal caps (ectoderm) were isolated, when control embryos reached the early gastrula stage, and were combined with untreated upper blastopore lip in the sandwich method. In two control series fibronectin or Holtfreter solution was injected into the blastocoel. The results of the experiments suggest that neural induction cannot be prevented by binding anti-FN to fibronectin, which covers the blastocoelic side of the ectoderm. The data support the view that extracellular matrix proteins are not themselves responsible for neural induction. However, in comparison with the control series a slight shift of the differentiation pattern in the spinocaudal direction could be observed in the anti-FN series. The possible role of extracellular proteins in the formation of a close juxtaposition of mesodermal and ectodermal target cells as a prerequisite for shortdistance transmission of neural inducers is discussed.

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Species referenced: Xenopus laevis
Genes referenced: fn1

References [+] :
Asashima, Effects of inducers on inner and outer gastrula ectoderm layers of Xenopus laevis. 1983, Pubmed, Xenbase