Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Genet
2017 Mar 01;961:3-8. doi: 10.1007/s12041-016-0721-3.
Show Gene links
Show Anatomy links
Cloning and expression analysis of zygote arrest 1 (Zar1) in New Zealand white rabbits.
Wang D
,
Xie SY
,
Zhang W
,
Sun CX
,
Huang T
,
Wang AS
,
Han XL
,
Sun GR
,
Li M
.
???displayArticle.abstract???
Zygote arrest 1 (Zar1) is an oocyte-specific maternal-effect gene. Previous studies indicate that Zar1 plays important role in early embryo development, but little is known about its function in rabbit. The objectives of this study were to clone the New Zealand white rabbit Zar1 gene and to investigate its expression in various organs in groups of animals with different reproductive traits.We obtained a 709-bp Zar1 cDNA fragment consisting of an 8-bp exon 1, 161-bp exon 2, 75-bp exon 3, 271-bp exon 4 and 194-bp 3'sequences. The rabbit Zar1 nucleotide sequence showed per cent identities of 91, 88, 88, 87, 86, 87, 76 and 82% with Zar1 orthologues in human, cattle, sheep, pig, mouse, rat, zebrafish and Xenopus laevis, respectively, indicating a high homology with other species and evolutionary conservation. Quantitative real-time polymerase chain reaction analyses revealed nonoocyte-specific Zar1 expression, with expression in spleen, lung, ovary, uterus, heart, liver and kidney. The expression level was highest in the lung. This study may lay the theoretical foundation for the study of ZAR1's biological function.
Ali-Benali,
Comparative expression of five Lea Genes during wheat seed development and in response to abiotic stresses by real-time quantitative RT-PCR.
2005, Pubmed
Ali-Benali,
Comparative expression of five Lea Genes during wheat seed development and in response to abiotic stresses by real-time quantitative RT-PCR.
2005,
Pubmed
Brevini,
Expression pattern of the maternal factor zygote arrest 1 (Zar1) in bovine tissues, oocytes, and embryos.
2004,
Pubmed
Burns,
Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos.
2003,
Pubmed
,
Xenbase
Christians,
Maternal effect of Hsf1 on reproductive success.
2000,
Pubmed
Farley,
Regulation of maternal mRNAs in early development.
2008,
Pubmed
Howell,
Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.
2001,
Pubmed
Leader,
Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes.
2002,
Pubmed
Ma,
Basonuclin: a novel mammalian maternal-effect gene.
2006,
Pubmed
Michailidis,
Expression of chicken zygote arrest 1 (Zar1) and Zar1-like genes during sexual maturation and embryogenesis.
2010,
Pubmed
Minami,
Zygotic gene activation and maternal factors in mammals.
2007,
Pubmed
Payer,
Stella is a maternal effect gene required for normal early development in mice.
2003,
Pubmed
Ramos,
The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development.
2004,
Pubmed
Roa S,
[Gene methylation patterns in digestive tumors].
2008,
Pubmed
Tadros,
The maternal-to-zygotic transition: a play in two acts.
2009,
Pubmed
Takagi,
DNA hypermethylation of zygote arrest 1 (ZAR1) in hepatitis C virus positive related hepatocellular carcinoma.
2013,
Pubmed
Telford,
Transition from maternal to embryonic control in early mammalian development: a comparison of several species.
1990,
Pubmed
Uzbekova,
Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells.
2006,
Pubmed
Wu,
Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries.
2003,
Pubmed
,
Xenbase
Wu,
Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition.
2003,
Pubmed
Yamamoto,
Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2.
2013,
Pubmed
,
Xenbase
