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Perlecan is required for FGF-2 signaling in the neural stem cell niche.
Kerever A
,
Mercier F
,
Nonaka R
,
de Vega S
,
Oda Y
,
Zalc B
,
Okada Y
,
Hattori N
,
Yamada Y
,
Arikawa-Hirasawa E
.
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In the adult subventricular zone (neurogenic niche), neural stem cells double-positive for two markers of subsets of neural stem cells in the adult central nervous system, glial fibrillary acidic protein and CD133, lie in proximity to fractones and to blood vessel basement membranes, which contain the heparan sulfate proteoglycan perlecan. Here, we demonstrate that perlecan deficiency reduces the number of both GFAP/CD133-positive neural stem cells in the subventricular zone and new neurons integrating into the olfactory bulb. We also show that FGF-2 treatment induces the expression of cyclin D2 through the activation of the Akt and Erk1/2 pathways and promotes neurosphere formation in vitro. However, in the absence of perlecan, FGF-2 fails to promote neurosphere formation. These results suggest that perlecan is a component of the neurogenic niche that regulates FGF-2 signaling and acts by promoting neural stem cell self-renewal and neurogenesis.
Altman,
Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.
1969, Pubmed
Altman,
Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.
1969,
Pubmed
ALTMAN,
Autoradiographic investigation of cell proliferation in the brains of rats and cats.
1963,
Pubmed
Arikawa-Hirasawa,
Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.
2001,
Pubmed
Arikawa-Hirasawa,
Perlecan is essential for cartilage and cephalic development.
1999,
Pubmed
Arikawa-Hirasawa,
A severe muscular dystrophy patient with an internally deleted very short (110 kD) dystrophin: presence of the binding site for dystrophin-associated glycoprotein (DAG) may not be enough for physiological function of dystrophin.
1995,
Pubmed
Arikawa-Hirasawa,
Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia.
2002,
Pubmed
Arikawa-Hirasawa,
Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice.
2002,
Pubmed
Aviezer,
Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis.
1994,
Pubmed
Brightman,
The distribution within the brain of ferritin injected into cerebrospinal fluid compartments. I. Ependymal distribution.
1965,
Pubmed
Brightman,
The brain's interstitial clefts and their glial walls.
2002,
Pubmed
Chan,
Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses.
2009,
Pubmed
Corti,
Isolation and characterization of murine neural stem/progenitor cells based on Prominin-1 expression.
2007,
Pubmed
Costell,
Perlecan maintains the integrity of cartilage and some basement membranes.
1999,
Pubmed
Dey,
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.
2000,
Pubmed
Doetsch,
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.
1999,
Pubmed
Doetsch,
Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain.
1997,
Pubmed
Douet,
Fractone-heparan sulphates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone.
2013,
Pubmed
Eriksson,
Neurogenesis in the adult human hippocampus.
1998,
Pubmed
Fatrai,
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.
2006,
Pubmed
Filla,
The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity.
1998,
Pubmed
Fischer,
Prospective isolation of adult neural stem cells from the mouse subependymal zone.
2011,
Pubmed
Girós,
Perlecan controls neurogenesis in the developing telencephalon.
2007,
Pubmed
Hagihara,
Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells.
2000,
Pubmed
Ishijima,
Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation.
2012,
Pubmed
Kerever,
Novel extracellular matrix structures in the neural stem cell niche capture the neurogenic factor fibroblast growth factor 2 from the extracellular milieu.
2007,
Pubmed
Kojima,
Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum.
2010,
Pubmed
Kowalczyk,
The critical role of cyclin D2 in adult neurogenesis.
2004,
Pubmed
Liu,
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.
2006,
Pubmed
Lois,
Long-distance neuronal migration in the adult mammalian brain.
1994,
Pubmed
Maric,
Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors.
2007,
Pubmed
Mercier,
Fractones and other basal laminae in the hypothalamus.
2003,
Pubmed
Mercier,
Anatomy of the brain neurogenic zones revisited: fractones and the fibroblast/macrophage network.
2002,
Pubmed
Mercier,
Heparan sulfate niche for cell proliferation in the adult brain.
2012,
Pubmed
Mirzadeh,
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.
2008,
Pubmed
Palmer,
FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain.
1995,
Pubmed
Palmer,
Vascular niche for adult hippocampal neurogenesis.
2000,
Pubmed
Pastrana,
Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny.
2009,
Pubmed
Petreanu,
Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction.
2002,
Pubmed
Raballo,
Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex.
2000,
Pubmed
Rapraeger,
In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding?
1995,
Pubmed
Seki,
Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat.
1993,
Pubmed
Shen,
Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions.
2008,
Pubmed
Sirko,
Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny.
2010,
Pubmed
Sun,
CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent.
2009,
Pubmed
Tavazoie,
A specialized vascular niche for adult neural stem cells.
2008,
Pubmed
Tsumaki,
Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation.
1999,
Pubmed
Uchida,
Direct isolation of human central nervous system stem cells.
2000,
Pubmed
Voigt,
Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts.
2002,
Pubmed
Winner,
Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb.
2002,
Pubmed
Xu,
Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition.
2010,
Pubmed
Yayon,
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
1991,
Pubmed
Zhou,
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.
2004,
Pubmed
