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Onco Targets Ther
2018 Mar 05;11:1229-1243. doi: 10.2147/OTT.S150829.
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Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis.
Wang G
,
Wang Q
,
Li Z
,
Liu C
,
He X
.
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Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated protein that plays an important role in spindle assembly and dynamics. However, the clinical and prognostic value of TPX2 in the digestive system cancers remains unclear. The objective of this review was to evaluate the association of TPX2 expression with disease-free survival (DFS), overall survival (OS), and clinicopathological features of digestive system cancers. The software Stata 12.0 was used to analyze the outcomes, including OS, disease-free survival (DFS), and clinicopathological characteristics. A total of 10 eligible studies with 906 patients were included. Elevated TPX2 expression was significantly associated with poor DFS (pooled hazard ratio [HR] =2.48, 95% confidence interval [CI]: 1.96-3.13) and OS (pooled HR =2.66, 95% CI: 2.04-3.48) of digestive system malignancies. Subgroup analyses showed that cancer type, sample size, study quality, and laboratory detection methods did not alter the significant prognostic value of TPX2. Additionally, TPX2 expression was found to be an independent predictive factor for DFS (HR =2.31, 95% CI: 1.78-3.01). TPX2 expression might be associated with TNM stage and pathological grade in digestive system cancer. In conclusion, TPX2 is an independent prognostic factor for survival of patients with digestive system cancer. Furthermore, its overexpression is associated with TNM stage and pathological grade in digestive system cancer.
Figure 1. Flowchart of the process of identifying relevant studies.Abbreviation: TPX2, Xenopus kinesin-like protein 2.
Figure 2. Meta-analysis of aberrant overexpression of TPX2 in digestive system cancers.Note: Weights are from random-effects analysis.Abbreviations: TPX2, Xenopus kinesin-like protein 2; OR, odds ratios; CI, confidence interval.
Figure 3. Meta-analysis of the pooled HRs of patients with elevated TPX2 expression.Note: Weights are from random-effects analysis.Abbreviations: TPX2, Xenopus kinesin-like protein 2; HR, hazard ratio; CI, confidence interval; DFS, disease-free survival; OS, overall survival.
Figure 4. Subgroup analyses were performed by the factors of cancer type (A), sample size (B), quality score (C), and laboratory detection method (D).Note: Weights are from random-effects analysis.Abbreviations: HR, hazard ratio; CI, confidence interval.
Figure 5. Sensitivity analysis of the effect of the individual study on the pooled HRs for the correlation between TPX2 and disease-free survival (A) and overall survival (B) in patients with digestive system cancer.Abbreviations: TPX2, Xenopus kinesin-like protein 2; HR, hazard ratio; CI, confidence interval.
Figure 6. Meta-analysis of the independent role of TPX2 in overall survival of cancer patients.Note: Weights are from random-effects analysis.Abbreviations: TPX2, Xenopus kinesin-like protein 2; HR, hazard ratio; CI, confidence interval.
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