Moiseeva TN , Bakkenist CJ .

R01 CA204173 NCI NIH HHS

Alver, Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. 2017, Pubmed, Xenbase

Alver, Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. 2017, Pubmed , Xenbase
Aparicio, The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. 2009, Pubmed , Xenbase
Balestrini, GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication. 2010, Pubmed , Xenbase
Ballabeni, Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase. 2009, Pubmed
Bell, Chromosome Duplication in Saccharomyces cerevisiae. 2016, Pubmed
Bermudez, Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. 2011, Pubmed
Berthet, Cdk2 knockout mice are viable. 2003, Pubmed
Blow, Xenopus cell-free extracts and their contribution to the study of DNA replication and other complex biological processes. 2016, Pubmed , Xenbase
Boos, Identification of a heteromeric complex that promotes DNA replication origin firing in human cells. 2013, Pubmed
Boos, Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. 2011, Pubmed
Bruck, Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase. 2015, Pubmed
Brustel, Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. 2017, Pubmed
Burkhart, Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. 1995, Pubmed
Caillat, The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins. 2015, Pubmed
Chagin, 4D Visualization of replication foci in mammalian cells corresponding to individual replicons. 2016, Pubmed
Chowdhury, The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. 2010, Pubmed , Xenbase
Cook, Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 2002, Pubmed
Couch, ATR phosphorylates SMARCAL1 to prevent replication fork collapse. 2013, Pubmed , Xenbase
Das, Replication timing is regulated by the number of MCMs loaded at origins. 2015, Pubmed
Das, MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity. 2014, Pubmed
Dierov, BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint. 2004, Pubmed
Di Perna, The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties. 2013, Pubmed
Dixon, Topological domains in mammalian genomes identified by analysis of chromatin interactions. 2012, Pubmed
Donovan, Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. 1997, Pubmed , Xenbase
Eser, Form and function of topologically associating genomic domains in budding yeast. 2017, Pubmed
Falck, The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. 2001, Pubmed
Feng, BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. 2016, Pubmed
Ferreira, Spatial organization of large-scale chromatin domains in the nucleus: a magnified view of single chromosome territories. 1997, Pubmed
Gao, Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation. 2014, Pubmed , Xenbase
Ge, Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. 2010, Pubmed
Ge, Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. 2007, Pubmed
Gerhardt, Identification of new human origins of DNA replication by an origin-trapping assay. 2006, Pubmed
Gindin, A chromatin structure-based model accurately predicts DNA replication timing in human cells. 2014, Pubmed
Giordano-Coltart, Studies of the properties of human origin recognition complex and its Walker A motif mutants. 2005, Pubmed , Xenbase
Gu, Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. 1992, Pubmed
Guo, Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. 2015, Pubmed , Xenbase
Hao, And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. 2015, Pubmed
Harper, Inhibition of cyclin-dependent kinases by p21. 1995, Pubmed
Heffernan, Cdc7-Dbf4 and the human S checkpoint response to UVC. 2007, Pubmed
Hiraga, Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. 2017, Pubmed
Huang, A Role of hIPI3 in DNA Replication Licensing in Human Cells. 2016, Pubmed
Hyrien, How MCM loading and spreading specify eukaryotic DNA replication initiation sites. 2016, Pubmed
Ibarra, Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. 2008, Pubmed
Im, RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells. 2015, Pubmed
Im, Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. 2009, Pubmed
Izumi, The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing. 2017, Pubmed
Jackson, Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. 1998, Pubmed
Jeon, Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. 2007, Pubmed
Jiang, Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. 1999, Pubmed
Jiang, Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. 1999, Pubmed
Katou, S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. 2003, Pubmed
Kim, Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways. 2007, Pubmed
Kitamura, Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. 2011, Pubmed
Köhler, Cdc45 is limiting for replication initiation in humans. 2016, Pubmed
Kulak, Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells. 2014, Pubmed
Kumagai, Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. 2010, Pubmed , Xenbase
Kumagai, Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. 2011, Pubmed , Xenbase
Kwok, Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway. 2015, Pubmed
Lee, Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. 2012, Pubmed
Leman, Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion. 2010, Pubmed
Lewis, Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome. 2017, Pubmed
Li, Role for Cdk1 (Cdc2)/cyclin A in preventing the mammalian origin recognition complex's largest subunit (Orc1) from binding to chromatin during mitosis. 2004, Pubmed
Liu, The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. 2006, Pubmed
Löb, 3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression. 2016, Pubmed
Macheret, Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress. 2018, Pubmed
Mahbubani, Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor. 1997, Pubmed , Xenbase
Maiorano, Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis. 2004, Pubmed , Xenbase
Merrick, Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. 2008, Pubmed
Merrick, Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. 2011, Pubmed
Mimura, Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. 2000, Pubmed , Xenbase
Miotto, HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin. 2010, Pubmed
Miotto, Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers. 2016, Pubmed
Moiseeva, ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1. 2017, Pubmed
Montagnoli, Drf1, a novel regulatory subunit for human Cdc7 kinase. 2002, Pubmed
Muramatsu, CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. 2010, Pubmed
Nishitani, Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region. 2004, Pubmed
O'Donnell, Principles and concepts of DNA replication in bacteria, archaea, and eukarya. 2013, Pubmed
Pasero, A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication. 1999, Pubmed
Perez-Arnaiz, An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation. 2016, Pubmed
Petersen, Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. 1999, Pubmed
Petryk, Replication landscape of the human genome. 2016, Pubmed
Picard, The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells. 2014, Pubmed
Pope, Topologically associating domains are stable units of replication-timing regulation. 2014, Pubmed
Rialland, Essential role of human CDT1 in DNA replication and chromatin licensing. 2002, Pubmed , Xenbase
Ritzi, Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin. 1998, Pubmed
Saha, Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. 1998, Pubmed
Sangoram, Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. 1998, Pubmed
Sansam, A mechanism for epigenetic control of DNA replication. 2018, Pubmed
Schmidt, Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein. 2008, Pubmed , Xenbase
Silva, Xenopus CDC7/DRF1 complex is required for the initiation of DNA replication. 2006, Pubmed , Xenbase
Soos, Formation of p27-CDK complexes during the human mitotic cell cycle. 1996, Pubmed
Sørensen, Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. 2003, Pubmed
Sugimoto, Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. 2015, Pubmed
Sugimoto, Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. 2009, Pubmed
Sugimoto, Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. 2011, Pubmed
Symeonidou, Multi-step loading of human minichromosome maintenance proteins in live human cells. 2013, Pubmed
Szambowska, Cdc45-induced loading of human RPA onto single-stranded DNA. 2017, Pubmed
Takeda, Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells. 2005, Pubmed
Tatsumi, The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1. 2003, Pubmed
Tenca, Cdc7 is an active kinase in human cancer cells undergoing replication stress. 2007, Pubmed
Tsuji, Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. 2006, Pubmed
Tsuji, The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. 2008, Pubmed , Xenbase
Utani, Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability. 2017, Pubmed
Welburn, How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A. 2007, Pubmed
Wohlschlegel, Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. 2000, Pubmed , Xenbase
Wu, H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. 2017, Pubmed
Xu, TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin. 2016, Pubmed
Yamazaki, Rif1 regulates the replication timing domains on the human genome. 2012, Pubmed
Yang, Modeling genome-wide replication kinetics reveals a mechanism for regulation of replication timing. 2010, Pubmed
Yeeles, Regulated eukaryotic DNA replication origin firing with purified proteins. 2015, Pubmed
Yoshizawa-Sugata, A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. 2005, Pubmed
Yoshizawa-Sugata, Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. 2007, Pubmed
Zegerman, Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. 2010, Pubmed
Zhang, A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells. 2016, Pubmed
Zhu, Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. 2007, Pubmed , Xenbase