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All animals use sensory systems to monitor external events and have to decide whether to move. Response times are long and variable compared to reflexes, and fast escape movements. The complexity of adult vertebrate brains makes it difficult to trace the neuronal circuits underlying basic decisions to move. To simplify the problem, we investigate the nervous system and responses of hatchling frog tadpoles which swim when their skin is stimulated. Studying the neuron-by-neuron pathway from sensory to hindbrain neurons, where the decision to swim is made, has revealed two simple pathways generating excitation which sums to threshold in these neurons to initiate swimming. The direct pathway leads to short, and reliable delays like an escape response. The other includes a population of sensory processing neurons which extend firing to introduce noise and delay into responses. These neurons provide a brief, sensory memory of the stimulus, that allows tadpoles to integrate stimuli occurring within a second or so of each other. We relate these findings to other studies and conclude that sensory memory makes a fundamental contribution to simple decisions and is present in the brainstem of a basic vertebrate at a surprisingly early stage in development.
Brody,
Neural underpinnings of the evidence accumulator.
2016, Pubmed
Brody,
Neural underpinnings of the evidence accumulator.
2016,
Pubmed
Buhl,
Sensory initiation of a co-ordinated motor response: synaptic excitation underlying simple decision-making.
2015,
Pubmed
,
Xenbase
Buhl,
The role of a trigeminal sensory nucleus in the initiation of locomotion.
2012,
Pubmed
,
Xenbase
Carpenter,
Neural computation of log likelihood in control of saccadic eye movements.
1995,
Pubmed
Clarke,
Sensory physiology, anatomy and immunohistochemistry of Rohon-Beard neurones in embryos of Xenopus laevis.
1984,
Pubmed
,
Xenbase
Clarke,
Interneurones in the Xenopus embryo spinal cord: sensory excitation and activity during swimming.
1984,
Pubmed
,
Xenbase
Daghfous,
Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.
2016,
Pubmed
Dale,
Reciprocal inhibitory interneurones in the Xenopus embryo spinal cord.
1985,
Pubmed
,
Xenbase
Deliagina,
Encoding and decoding of reticulospinal commands.
2002,
Pubmed
Di Prisco,
Role of sensory-evoked NMDA plateau potentials in the initiation of locomotion.
1997,
Pubmed
Domenici,
Animal escapology I: theoretical issues and emerging trends in escape trajectories.
2011,
Pubmed
Durstewitz,
Neurocomputational models of working memory.
2000,
Pubmed
Edwards,
Fifty years of a command neuron: the neurobiology of escape behavior in the crayfish.
1999,
Pubmed
Ferrario,
Bifurcations of Limit Cycles in a Reduced Model of the Xenopus Tadpole Central Pattern Generator.
2018,
Pubmed
,
Xenbase
Ferrario,
Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network.
2018,
Pubmed
,
Xenbase
Fetcho,
Spinal network of the Mauthner cell.
1991,
Pubmed
Gold,
The neural basis of decision making.
2007,
Pubmed
Goldman-Rakic,
Cellular basis of working memory.
1995,
Pubmed
Hanes,
Neural control of voluntary movement initiation.
1996,
Pubmed
Herberholz,
Decision Making and Behavioral Choice during Predator Avoidance.
2012,
Pubmed
Hull,
Modelling Feedback Excitation, Pacemaker Properties and Sensory Switching of Electrically Coupled Brainstem Neurons Controlling Rhythmic Activity.
2016,
Pubmed
,
Xenbase
Hull,
Modelling the Effects of Electrical Coupling between Unmyelinated Axons of Brainstem Neurons Controlling Rhythmic Activity.
2015,
Pubmed
,
Xenbase
Jamieson,
A possible pathway connecting the photosensitive pineal eye to the swimming central pattern generator in young Xenopus laevis tadpoles.
1999,
Pubmed
,
Xenbase
Jordan,
Descending command systems for the initiation of locomotion in mammals.
2008,
Pubmed
Kahn,
The central nervous origin of the swimming motor pattern in embryos of Xenopus laevis.
1982,
Pubmed
,
Xenbase
Kimura,
Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming.
2013,
Pubmed
Korn,
The Mauthner cell half a century later: a neurobiological model for decision-making?
2005,
Pubmed
Koutsikou,
A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times.
2018,
Pubmed
,
Xenbase
Kristan,
Neuronal decision-making circuits.
2008,
Pubmed
Li,
Generation of locomotion rhythms without inhibition in vertebrates: the search for pacemaker neurons.
2011,
Pubmed
,
Xenbase
Li,
Persistent responses to brief stimuli: feedback excitation among brainstem neurons.
2006,
Pubmed
,
Xenbase
Li,
The spinal interneurons and properties of glutamatergic synapses in a primitive vertebrate cutaneous flexion reflex.
2003,
Pubmed
,
Xenbase
Li,
Locomotor rhythm maintenance: electrical coupling among premotor excitatory interneurons in the brainstem and spinal cord of young Xenopus tadpoles.
2009,
Pubmed
,
Xenbase
Li,
The generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator.
2014,
Pubmed
,
Xenbase
Li,
Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors.
2010,
Pubmed
,
Xenbase
McLean,
Peeling back the layers of locomotor control in the spinal cord.
2015,
Pubmed
Messina,
Elimination of Left-Right Reciprocal Coupling in the Adult Lamprey Spinal Cord Abolishes the Generation of Locomotor Activity.
2017,
Pubmed
Noorani,
The LATER model of reaction time and decision.
2016,
Pubmed
Roberts,
Responses of hatchling Xenopus tadpoles to water currents: first function of lateral line receptors without cupulae.
2009,
Pubmed
,
Xenbase
Roberts,
Characterization and Function of Spinal Excitatory Interneurons with Commissural Projections in Xenopus laevis embryos.
1990,
Pubmed
,
Xenbase
Roberts,
Can simple rules control development of a pioneer vertebrate neuronal network generating behavior?
2014,
Pubmed
,
Xenbase
Roberts,
How neurons generate behavior in a hatchling amphibian tadpole: an outline.
2010,
Pubmed
,
Xenbase
Roberts,
The anatomy and function of 'free' nerve endings in an amphibian skin sensory system.
1977,
Pubmed
,
Xenbase
Schall,
Neural correlates of decision processes: neural and mental chronometry.
2003,
Pubmed
Smith,
Psychology and neurobiology of simple decisions.
2004,
Pubmed
Soffe,
Defining the excitatory neurons that drive the locomotor rhythm in a simple vertebrate: insights into the origin of reticulospinal control.
2009,
Pubmed
,
Xenbase
Wang,
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.
2013,
Pubmed
