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The tail of Xenopus tadpole is an excellent model for appendage regeneration studies. We analyzed the distribution pattern of the transcription factor Xvent-2 mRNA and protein in the beginning of the regeneration of Xenopus tadpoletail stumps after amputation. We revealed the emergence of Xvent-2 mRNA and protein in regeneration bud during the first day after amputation. The data obtained confirm that soon after amputation of the part of the Xenopus tadpoletail, there occurs the emergence of a structure, to some extend, resembling the early embryonic tail bud.
Figure 1 The spatial distribution of Xvent-2 protein and mRNA in the regenerating tails of Xenopus embryos. (A,B,C,D) Immunostaining; (E,F,G,H) in situ hybridization. A: 0 h; C: 6 h; D,E,F: 20 h after amputation; G,H: amputated tail parts; B: cross-section of the tail in the amputation area. Sections thickness about 0.2 mm. nc, notochord; sc, spinal cord; a, dorsal aorta; v, posterior cardinal vein; av, dorsal lateral anastomosing vessel; f, fin; H, control in situ hybridization with a sense probe. Scale bars: A–E,G,H, 500 µm; F, 100 µm.
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