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???displayArticle.abstract??? Znf703 is an RAR- and Wnt-inducible transcription factor that exhibits a complex expression pattern in the developing embryo: Znf703 mRNA is found in the early circumblastoporal ring, then later throughout the neural plate and its border, and subsequently in the mid/hindbrain and somites. We show that Znf703 has a different and separable function in early mesoderm versus neural crest and placode development. Independent of its early knockdown phenotype on Gdf3 and Wnt8, Znf703 disrupts patterning of distinct neural crest migratory streams normally delineated by Sox10, Twist, and Foxd3 and inhibits otocyst formation and otic expression of Sox10 and Eya1. Furthermore, Znf703 promotes massive overgrowth of SOX2+ cells, disrupting the SoxB1 balance at the neural plate border. Despite prominent expression in other neural plate border-derived cranial and sensory domains, Znf703 is selectively absent from the otocyst, suggesting that Znf703 must be specifically cleared or down-regulated for proper otic development. We show that mutation of the putative Groucho-repression domain does not ameliorate Znf703 effects on mesoderm, neural crest, and placodes. We instead provide evidence that Znf703 requires the Buttonhead domain for transcriptional repression.
Andreazzoli,
Cloning and expression of noz1, a zebrafish zinc finger gene related to Drosophila nocA.
2001, Pubmed
Andreazzoli,
Cloning and expression of noz1, a zebrafish zinc finger gene related to Drosophila nocA.
2001,
Pubmed
Bordo,
Suggestions for "safe" residue substitutions in site-directed mutagenesis.
1991,
Pubmed
Brown,
Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure.
2009,
Pubmed
Buitrago-Delgado,
NEURODEVELOPMENT. Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells.
2015,
Pubmed
,
Xenbase
Chang,
Identification of a developmentally regulated striatum-enriched zinc-finger gene, Nolz-1, in the mammalian brain.
2004,
Pubmed
Cheah,
The Drosophila l(2)35Ba/nocA gene encodes a putative Zn finger protein involved in the development of the embryonic brain and the adult ocellar structures.
1994,
Pubmed
Crooks,
WebLogo: a sequence logo generator.
2004,
Pubmed
Diez del Corral,
Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension.
2003,
Pubmed
Dorfman,
Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches.
2002,
Pubmed
Duncan,
Continued expression of GATA3 is necessary for cochlear neurosensory development.
2013,
Pubmed
Frenz,
Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.
2010,
Pubmed
Gentsch,
In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency.
2013,
Pubmed
,
Xenbase
Goldstein,
Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho.
1999,
Pubmed
Groves,
Setting appropriate boundaries: fate, patterning and competence at the neural plate border.
2014,
Pubmed
,
Xenbase
Hama,
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain.
2011,
Pubmed
Holland,
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
2011,
Pubmed
Hollenberg,
Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination.
1993,
Pubmed
Hong,
Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm.
2008,
Pubmed
,
Xenbase
Hong,
Znf703, a novel target of Pax3 and Zic1, regulates hindbrain and neural crest development in Xenopus.
2017,
Pubmed
,
Xenbase
Janesick,
RARγ is required for mesodermal gene expression prior to gastrulation in Xenopus.
2018,
Pubmed
,
Xenbase
Janesick,
RIPPLY3 is a retinoic acid-inducible repressor required for setting the borders of the pre-placodal ectoderm.
2012,
Pubmed
,
Xenbase
Janesick,
RARβ2 is required for vertebrate somitogenesis.
2017,
Pubmed
,
Xenbase
Janesick,
On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens.
2016,
Pubmed
Janesick,
ERF and ETV3L are retinoic acid-inducible repressors required for primary neurogenesis.
2013,
Pubmed
,
Xenbase
Janesick,
Active repression by RARγ signaling is required for vertebrate axial elongation.
2014,
Pubmed
,
Xenbase
Jansson,
Making sense of Wnt signaling-linking hair cell regeneration to development.
2015,
Pubmed
Katoh,
MAFFT version 5: improvement in accuracy of multiple sequence alignment.
2005,
Pubmed
Kjolby,
Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.
2017,
Pubmed
,
Xenbase
Koide,
Active repression of RAR signaling is required for head formation.
2001,
Pubmed
,
Xenbase
Kolm,
Efficient hormone-inducible protein function in Xenopus laevis.
1995,
Pubmed
,
Xenbase
Kumar,
Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex.
2016,
Pubmed
Kuraku,
aLeaves facilitates on-demand exploration of metazoan gene family trees on MAFFT sequence alignment server with enhanced interactivity.
2013,
Pubmed
Lalevée,
Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp).
2011,
Pubmed
Lilleväli,
Gata3 is required for early morphogenesis and Fgf10 expression during otic development.
2006,
Pubmed
Lolas,
Charting Brachyury-mediated developmental pathways during early mouse embryogenesis.
2014,
Pubmed
Luo,
GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea.
2013,
Pubmed
Mendoza-Parra,
Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics.
2011,
Pubmed
Miwata,
Systematic analysis of embryonic expression profiles of zinc finger genes in Ciona intestinalis.
2006,
Pubmed
Monsoro-Burq,
Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals.
2003,
Pubmed
,
Xenbase
Moutier,
Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.
2012,
Pubmed
Nakamura,
Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β-catenin recruitment to cis-regulatory modules.
2016,
Pubmed
,
Xenbase
Nakamura,
A novel subfamily of zinc finger genes involved in embryonic development.
2004,
Pubmed
Nakamura,
Nlz1/Znf703 acts as a repressor of transcription.
2008,
Pubmed
Ohyama,
Wnt signals mediate a fate decision between otic placode and epidermis.
2006,
Pubmed
Ono,
FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.
2014,
Pubmed
Pereira-Castro,
Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression.
2013,
Pubmed
Plouhinec,
A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates.
2017,
Pubmed
,
Xenbase
Roellig,
Dynamic transcriptional signature and cell fate analysis reveals plasticity of individual neural plate border cells.
2017,
Pubmed
Rogers,
Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives.
2009,
Pubmed
,
Xenbase
Runko,
Isolation of nlz2 and characterization of essential domains in Nlz family proteins.
2004,
Pubmed
Runko,
Nlz belongs to a family of zinc-finger-containing repressors and controls segmental gene expression in the zebrafish hindbrain.
2003,
Pubmed
Sagerström,
Isolation and characterization of posteriorly restricted genes in the zebrafish gastrula.
2001,
Pubmed
Savory,
Identification of novel retinoic acid target genes.
2014,
Pubmed
Schlosser,
Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion.
2008,
Pubmed
,
Xenbase
Shahi,
The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion.
2015,
Pubmed
Shahi,
ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression.
2017,
Pubmed
Slorach,
Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization.
2011,
Pubmed
Steventon,
Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction.
2009,
Pubmed
,
Xenbase
Theveneau,
Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration.
2012,
Pubmed
,
Xenbase
Trevers,
Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells.
2018,
Pubmed
Umesono,
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.
1991,
Pubmed
Uray,
Retinoids and rexinoids in cancer prevention: from laboratory to clinic.
2016,
Pubmed
Wakamatsu,
Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development.
2004,
Pubmed
Yao,
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish.
2014,
Pubmed
Zhang,
Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo.
2001,
Pubmed
