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Hybrids provide an interesting model to study the evolution of sex-determining genes and sex chromosome systems as they offer the opportunity to see how independently evolving sex-determining pathways interact in vivo. In this context, the genus Xenopus represents a stimulating model, since species with non-homologous sex chromosomes and different sex-determining genes have been identified. In addition, the possibility of interspecies breeding is favoured in this group, which arose by alloploidization events, with species ploidy ranging from 2n = 2x = 20 in X. tropicalis (the only diploid representative of the genus) to 2n = 12x = 108 in X. ruwenzoriensis. To study how two sex-determining genes interact in vivo, X. laevis × X. tropicalis hybrids were produced. Gonadal differentiation in these hybrids revealed that the dm-w gene is dominant over X. tropicalis male-determining sex chromosomes (Y or Z), even though the Y chromosome is dominant in X. tropicalis (Y > W>Z). In the absence of the dm-w gene (the Z chromosome from X. laevis is present), the W chromosome from X. tropicalis is able to trigger ovarian development. Testicular differentiation will take place in the absence of W chromosomes from any of the parental species. The dominance/recessivity relationships between these sex-determining loci in the context of either parental genome remains unknown. This article is part of the theme issue 'Challenging the paradigm in sex chromosome evolution: empirical and theoretical insights with a focus on vertebrates (Part II)'.
Albrecht,
DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit.
1997, Pubmed
Albrecht,
DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit.
1997,
Pubmed
Bergstrom,
Related function of mouse SOX3, SOX9, and SRY HMG domains assayed by male sex determination.
2000,
Pubmed
Bewick,
Evolution of the closely related, sex-related genes DM-W and DMRT1 in African clawed frogs (Xenopus).
2011,
Pubmed
,
Xenbase
Bullejos,
Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal.
2005,
Pubmed
Carlisle,
Absence of correlation between Sry polymorphisms and XY sex reversal caused by the M. m. domesticus Y chromosome.
1996,
Pubmed
Eicher,
Inherited sex reversal in mice: identification of a new primary sex-determining gene.
1983,
Pubmed
Evans,
A mitochondrial DNA phylogeny of African clawed frogs: phylogeography and implications for polyploid evolution.
2004,
Pubmed
,
Xenbase
Furman,
Sequential Turnovers of Sex Chromosomes in African Clawed Frogs (Xenopus) Suggest Some Genomic Regions Are Good at Sex Determination.
2016,
Pubmed
,
Xenbase
Furman,
Divergent Evolutionary Trajectories of Two Young, Homomorphic, and Closely Related Sex Chromosome Systems.
2018,
Pubmed
,
Xenbase
Furman,
Limited genomic consequences of hybridization between two African clawed frogs, Xenopus gilli and X. laevis (Anura: Pipidae).
2017,
Pubmed
,
Xenbase
Geach,
Developmental genetics in Xenopus tropicalis.
2011,
Pubmed
,
Xenbase
Gibeaux,
Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.
2018,
Pubmed
,
Xenbase
Kato,
A sex-determining region on the Y chromosome controls the sex-reversal ratio in interspecific hybrids between Oryzias curvinotus females and Oryzias latipes males.
2010,
Pubmed
Kawamura,
Suitability of hybrid mackerel (Scomber australasicus × S. japonicus) with germ cell-less sterile gonads as a recipient for transplantation of bluefin tuna germ cells.
2020,
Pubmed
Kobel,
Hyperdiploid species hybrids for gene mapping in Xenopus.
1979,
Pubmed
,
Xenbase
Koopman,
Male development of chromosomally female mice transgenic for Sry.
1991,
Pubmed
Lovell-Badge,
Sex-determining genes in mice: building pathways.
2002,
Pubmed
Malone,
Sterility and gene expression in hybrid males of Xenopus laevis and X. muelleri.
2007,
Pubmed
,
Xenbase
Matsuda,
Oryzias curvinotus has DMY, a gene that is required for male development in the medaka, O. latipes.
2003,
Pubmed
Matsuda,
DMY is a Y-specific DM-domain gene required for male development in the medaka fish.
2002,
Pubmed
Mawaribuchi,
Sex chromosome differentiation and the W- and Z-specific loci in Xenopus laevis.
2017,
Pubmed
,
Xenbase
Mawaribuchi,
Molecular Evolution of Two Distinct dmrt1 Promoters for Germ and Somatic Cells in Vertebrate Gonads.
2017,
Pubmed
,
Xenbase
Müller,
Diplotene chromosomes of Xenopus hybrid oocytes.
1977,
Pubmed
,
Xenbase
Nagamine,
Sex reversal caused by Mus musculus domesticus Y chromosomes linked to variant expression of the testis-determining gene Sry.
1999,
Pubmed
Narbonne,
Deficient induction response in a Xenopus nucleocytoplasmic hybrid.
2011,
Pubmed
,
Xenbase
Olmstead,
Genotyping sex in the amphibian, Xenopus (Silurana) tropicalis, for endocrine disruptor bioassays.
2010,
Pubmed
,
Xenbase
Pan,
Vertebrate sex-determining genes play musical chairs.
2016,
Pubmed
Pannetier,
Goat SRY induces testis development in XX transgenic mice.
2006,
Pubmed
Piprek,
Differential effects of busulfan on gonadal development in five divergent anuran species.
2012,
Pubmed
,
Xenbase
Roco,
Coexistence of Y, W, and Z sex chromosomes in Xenopus tropicalis.
2015,
Pubmed
,
Xenbase
Session,
Genome evolution in the allotetraploid frog Xenopus laevis.
2016,
Pubmed
,
Xenbase
Shinomiya,
Interspecific hybridization between Oryzias latipes and Oryzias curvinotus causes XY sex reversal.
2006,
Pubmed
Sinclair,
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.
1990,
Pubmed
Sive,
Inducing Ovulation in Xenopus laevis.
2007,
Pubmed
,
Xenbase
Thiébaud,
Diploid gynogenesis in Xenopus laevis and the localization with respect to the centromere of the gene for periodic albinism ap.
1984,
Pubmed
,
Xenbase
Tucker,
Rapid evolution of the sex determining locus in Old World mice and rats.
1993,
Pubmed
Whitfield,
Rapid sequence evolution of the mammalian sex-determining gene SRY.
1993,
Pubmed
Wlizla,
Generation and Care of Xenopus laevis and Xenopus tropicalis Embryos.
2018,
Pubmed
,
Xenbase
Yoshikawa,
Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells.
2018,
Pubmed
Yoshimoto,
A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis.
2008,
Pubmed
,
Xenbase
Yoshimoto,
Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual dimorphism of Xenopus laevis: implications of a ZZ/ZW-type sex-determining system.
2010,
Pubmed
,
Xenbase
Zarkower,
DMRT genes in vertebrate gametogenesis.
2013,
Pubmed
