Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Eur J Immunol
2021 Nov 01;5111:2590-2606. doi: 10.1002/eji.202149383.
Show Gene links
Show Anatomy links
Identification of the Fc-alpha/mu receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport.
Flowers EM
,
Neely HR
,
Guo J
,
Almeida T
,
Ohta Y
,
Castro CD
,
Flajnik MF
.
???displayArticle.abstract???
The polyimmunoglobulin receptor (pIgR) transcytoses J chain-containing antibodies through mucosal epithelia. In mammals, two cis-duplicates of PIGR, FCMR, and FCAMR, flank the PIGR gene. A PIGR duplication is first found in amphibians, previously annotated as PIGR2 (herein xlFCAMR), and is expressed by APCs. We demonstrate that xlFcamR is the equivalent of mammalian FcamR. It has been assumed that pIgR is the oldest member of this family, yet our data could not distinguish whether PIGR or FCAMR emerged first; however, FCMR was the last family member to emerge. Interestingly, bony fish "pIgR" is not an orthologue of tetrapod pIgR, and possibly acquired its function via convergent evolution. PIGR/FCAMR/FCMR are members of a larger superfamily, including TREM, CD300, and NKp44, which we name the "double-disulfide Ig superfamily" (ddIgSF). Domains related to each ddIgSF family were identified in cartilaginous fish (sharks, chimeras) and encoded in a single gene cluster syntenic to the human pIgR locus. Thus, the ddIgSF families date back to the earliest antibody-based adaptive immunity, but apparently not before. Finally, our data strongly suggest that the J chain arose in evolution only for Ig multimerization. This study provides a framework for further studies of pIgR and the ddIgSF in vertebrates.
Akula,
The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution.
2017, Pubmed
Akula,
The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution.
2017,
Pubmed
Akula,
Fc receptors for immunoglobulins and their appearance during vertebrate evolution.
2014,
Pubmed
Allcock,
The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.
2003,
Pubmed
Aydar,
Altered regulation of Fc gamma RII on aged follicular dendritic cells correlates with immunoreceptor tyrosine-based inhibition motif signaling in B cells and reduced germinal center formation.
2003,
Pubmed
Barrington,
B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors.
2002,
Pubmed
Borrego,
The CD300 molecules: an emerging family of regulators of the immune system.
2013,
Pubmed
Bouchon,
TREM-1 amplifies inflammation and is a crucial mediator of septic shock.
2001,
Pubmed
Bowes,
Xenbase: gene expression and improved integration.
2010,
Pubmed
,
Xenbase
Braathen,
Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians.
2007,
Pubmed
,
Xenbase
Brandtzaeg,
Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins.
,
Pubmed
Brandtzaeg,
Human secretory immunoglobulins. VII. Concentrations of parotid IgA and other secretory proteins in relation to the rate of flow and duration of secretory stimulus.
1971,
Pubmed
Brandtzaeg,
Human secretory immunoglobulins. V. Occurrence of secretory piece in human serum.
1971,
Pubmed
Bromage,
Use of staphylococcal protein A in the analysis of teleost immunoglobulin structural diversity.
2004,
Pubmed
Cannon,
Ancient divergence of a complex family of immune-type receptor genes.
2006,
Pubmed
Cantoni,
The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.
2003,
Pubmed
Castro,
Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny.
2013,
Pubmed
Choi,
Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses.
2013,
Pubmed
Dooley,
Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum.
2005,
Pubmed
Feng,
Molecular cloning and functional analysis of polymeric immunoglobulin receptor gene in orange-spotted grouper (Epinephelus coioides).
2009,
Pubmed
Flajnik,
Origin and evolution of the adaptive immune system: genetic events and selective pressures.
2010,
Pubmed
Ford,
TREM and TREM-like receptors in inflammation and disease.
2009,
Pubmed
Fu,
Identification of Two Nonrearranging IgSF Genes in Chicken Reveals a Novel Family of Putative Remnants of an Antigen Receptor Precursor.
2019,
Pubmed
Ghumra,
Structural requirements for the interaction of human IgM and IgA with the human Fcalpha/mu receptor.
2009,
Pubmed
Hamuro,
A teleost polymeric Ig receptor exhibiting two Ig-like domains transports tetrameric IgM into the skin.
2007,
Pubmed
Heimroth,
Effects of Experimental Terrestrialization on the Skin Mucus Proteome of African Lungfish (Protopterus dolloi).
2018,
Pubmed
Hendrickson,
Altered hepatic transport of immunoglobulin A in mice lacking the J chain.
1995,
Pubmed
Hohman,
Sequence and expression pattern of J chain in the amphibian, Xenopus laevis.
1997,
Pubmed
,
Xenbase
Hohman,
J chain in the nurse shark: implications for function in a lower vertebrate.
2003,
Pubmed
Honda,
Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice.
2009,
Pubmed
Horton,
Effect of early thymectomy on the cellular changes occuring in the spleen of the clawed toad following administration of soluble antigen.
1974,
Pubmed
,
Xenbase
Hsu,
Studies on Xenopus immunoglobulins using monoclonal antibodies.
1984,
Pubmed
,
Xenbase
Hsu,
A third immunoglobulin class in amphibians.
1985,
Pubmed
,
Xenbase
Kaetzel,
The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.
1991,
Pubmed
Karimi,
Xenbase: a genomic, epigenomic and transcriptomic model organism database.
2018,
Pubmed
,
Xenbase
Kasahara,
Genome dynamics of the major histocompatibility complex: insights from genome paralogy.
1999,
Pubmed
Klesney-Tait,
The TREM receptor family and signal integration.
2006,
Pubmed
Kortum,
Differential expression and ligand binding indicate alternative functions for zebrafish polymeric immunoglobulin receptor (pIgR) and a family of pIgR-like (PIGRL) proteins.
2014,
Pubmed
Kubagawa,
Functional Roles of the IgM Fc Receptor in the Immune System.
2019,
Pubmed
Kubagawa,
Identity of the elusive IgM Fc receptor (FcmuR) in humans.
2009,
Pubmed
Kühn,
The membrane receptor for polymeric immunoglobulin is structurally related to secretory component. Isolation and characterization of membrane secretory component from rabbit liver and mammary gland.
1981,
Pubmed
Kumar,
Structure of the secretory immunoglobulin A core.
2020,
Pubmed
Kurita,
Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules.
2009,
Pubmed
Lang,
Involvement of Toso in activation of monocytes, macrophages, and granulocytes.
2013,
Pubmed
Lewis,
IgA in the horse: cloning of equine polymeric Ig receptor and J chain and characterization of recombinant forms of equine IgA.
2010,
Pubmed
Li,
Structural insights into immunoglobulin M.
2020,
Pubmed
Mantis,
Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut.
2011,
Pubmed
Mashoof,
Ancient T-independence of mucosal IgX/A: gut microbiota unaffected by larval thymectomy in Xenopus laevis.
2013,
Pubmed
,
Xenbase
Mathias,
N-Glycans on secretory component: mediators of the interaction between secretory IgA and gram-positive commensals sustaining intestinal homeostasis.
2011,
Pubmed
McCumber,
A comparative study of J chain structure and stoichiometry in human and nurse shark IgM.
1976,
Pubmed
Montgomery,
Teleost IgSF immunoregulatory receptors.
2011,
Pubmed
Mostov,
Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms.
1980,
Pubmed
Mostov,
Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA.
1986,
Pubmed
Mostov,
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains.
,
Pubmed
Mussmann,
Is Xenopus IgX an analog of IgA?
1996,
Pubmed
,
Xenbase
Neely,
"Double-duty" conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells.
2018,
Pubmed
,
Xenbase
Nei,
Concerted and birth-and-death evolution of multigene families.
2005,
Pubmed
Nei,
Selectionism and neutralism in molecular evolution.
2005,
Pubmed
Niu,
The polymeric immunoglobulin receptor-like protein from Marsupenaeus japonicus is a receptor for white spot syndrome virus infection.
2019,
Pubmed
Ohta,
Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics.
2019,
Pubmed
,
Xenbase
Qin,
Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response.
2000,
Pubmed
Ribeiro,
A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite.
2011,
Pubmed
Rombout,
Expression of the polymeric Immunoglobulin Receptor (pIgR) in mucosal tissues of common carp (Cyprinus carpio L.).
2008,
Pubmed
Rumfelt,
Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish.
2004,
Pubmed
Sakamoto,
A novel Fc receptor for IgA and IgM is expressed on both hematopoietic and non-hematopoietic tissues.
2001,
Pubmed
Sela,
GUIDANCE2: accurate detection of unreliable alignment regions accounting for the uncertainty of multiple parameters.
2015,
Pubmed
Sheng,
Polymeric Immunoglobulin Receptor Mediates Immune Excretion of Mucosal IgM-Antigen Complexes Across Intestinal Epithelium in Flounder (Paralichthys olivaceus).
2018,
Pubmed
Shibuya,
Immune regulation by Fcα/μ receptor (CD351) on marginal zone B cells and follicular dendritic cells.
2015,
Pubmed
Shima,
Identification of TOSO/FAIM3 as an Fc receptor for IgM.
2010,
Pubmed
Stadtmueller,
The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins.
2016,
Pubmed
Stet,
Novel immunoglobulin-like transcripts in teleost fish encode polymorphic receptors with cytoplasmic ITAM or ITIM and a new structural Ig domain similar to the natural cytotoxicity receptor NKp44.
2005,
Pubmed
Tadiso,
Analysis of polymeric immunoglobulin receptor- and CD300-like molecules from Atlantic salmon.
2011,
Pubmed
Trifinopoulos,
W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis.
2016,
Pubmed
Turnbull,
Cutting edge: TREM-2 attenuates macrophage activation.
2006,
Pubmed
van der Poel,
Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB.
2019,
Pubmed
Venkatesh,
Elephant shark genome provides unique insights into gnathostome evolution.
2014,
Pubmed
Vernet,
Evolutionary study of multigenic families mapping close to the human MHC class I region.
1993,
Pubmed
,
Xenbase
Wang,
Human Fcalpha/muR and pIgR distribute differently in intestinal tissues.
2009,
Pubmed
Wang,
Emerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune Homeostasis.
2016,
Pubmed
Yoshizawa,
Involvement of Fcα/μR (CD351) in autoantibody production.
2014,
Pubmed
Zhang,
Characterization of IgM-binding protein: A pIgR-like molecule expressed by intestinal epithelial cells in the common carp (Cyprinus carpio L.).
2015,
Pubmed
Zhang,
The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells.
2000,
Pubmed
Zimmerman,
Zebrafish immunoglobulin IgD: unusual exon usage and quantitative expression profiles with IgM and IgZ/T heavy chain isotypes.
2011,
Pubmed
