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Cells
2022 Jan 11;112:. doi: 10.3390/cells11020234.
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SCF Ligases and Their Functions in Oogenesis and Embryogenesis-Summary of the Most Important Findings throughout the Animal Kingdom.
Kinterová V
,
Kaňka J
,
Bartková A
,
Toralová T
.
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SCF-dependent proteolysis was first discovered via genetic screening of budding yeast almost 25 years ago. In recent years, more and more functions of SCF (Skp1-Cullin 1-F-box) ligases have been described, and we can expect the number of studies on this topic to increase. SCF ligases, which are E3 ubiquitin multi-protein enzymes, catalyse protein ubiquitination and thus allow protein degradation mediated by the 26S proteasome. They play a crucial role in the degradation of cell cycle regulators, regulation of the DNA repair and centrosome cycle and play an important role in several diseases. SCF ligases seem to be needed during all phases of development, from oocyte formation through fertilization, activation of the embryonic genome to embryo implantation. In this review, we summarize known data on SCF ligase-mediated degradation during oogenesis and embryogenesis. In particular, SCFβTrCP and SCFSEL-10/FBXW7 are among the most important and best researched ligases during early development. SCFβTrCP is crucial for the oogenesis of Xenopus and mouse and also in Xenopus and Drosophila embryogenesis. SCFSEL-10/FBXW7 participates in the degradation of several RNA-binding proteins and thereby affects the regulation of gene expression during the meiosis of C. elegans. Nevertheless, a large number of SCF ligases that are primarily involved in embryogenesis remain to be elucidated.
Adhikari,
Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes.
2012, Pubmed
Adhikari,
Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes.
2012,
Pubmed
Aoki,
Regulation of transcriptional activity during the first and second cell cycles in the preimplantation mouse embryo.
1997,
Pubmed
Avilés-Pagán,
Identification of New Regulators of the Oocyte-to-Embryo Transition in Drosophila.
2020,
Pubmed
Bai,
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
1996,
Pubmed
Barckmann,
Control of maternal mRNA stability in germ cells and early embryos.
2013,
Pubmed
Benesova,
Characterization of SCF-Complex during Bovine Preimplantation Development.
2016,
Pubmed
Benesova,
Potential Involvement of SCF-Complex in Zygotic Genome Activation During Early Bovine Embryo Development.
2017,
Pubmed
Bennett,
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
2010,
Pubmed
Cheng,
F-box protein FBXO30 mediates retinoic acid receptor γ ubiquitination and regulates BMP signaling in neural tube defects.
2019,
Pubmed
Collart,
Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition.
2017,
Pubmed
,
Xenbase
Cui,
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
2011,
Pubmed
Cunha-Ferreira,
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
2013,
Pubmed
Daldello,
Correction: Control of Cdc6 accumulation by Cdk1 and MAPK is essential for completion of oocyte meiotic divisions in Xenopus (doi:10.1242/jcs.166553).
2018,
Pubmed
,
Xenbase
Dealy,
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.
1999,
Pubmed
De La Chesnaye,
Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary.
2008,
Pubmed
Galan,
Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.
1999,
Pubmed
Glickman,
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.
2002,
Pubmed
Guan,
SKP1 drives the prophase I to metaphase I transition during male meiosis.
2020,
Pubmed
Hansen,
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.
2004,
Pubmed
,
Xenbase
Higuchi,
Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway.
2019,
Pubmed
Jackson,
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.
2000,
Pubmed
Jia,
RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival.
2009,
Pubmed
Jia,
RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins.
2011,
Pubmed
Jin,
Fbxo30 regulates chromosome segregation of oocyte meiosis.
2019,
Pubmed
Jones,
GLD-1, a cytoplasmic protein essential for oocyte differentiation, shows stage- and sex-specific expression during Caenorhabditis elegans germline development.
1996,
Pubmed
Jones,
A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.
2008,
Pubmed
Jukam,
Zygotic Genome Activation in Vertebrates.
2017,
Pubmed
Kanka,
Gene expression during minor genome activation in preimplantation bovine development.
2009,
Pubmed
Kepkova,
Transcriptomic analysis of in vivo and in vitro produced bovine embryos revealed a developmental change in cullin 1 expression during maternal-to-embryonic transition.
2011,
Pubmed
Kim,
Skp1 Dimerization Conceals Its F-Box Protein Binding Site.
2020,
Pubmed
Kinterova,
Inhibition of Skp1-Cullin-F-box complexes during bovine oocyte maturation and preimplantation development leads to delayed development of embryos†.
2019,
Pubmed
Kisielnicka,
MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression.
2018,
Pubmed
Kline,
Repetitive calcium transients and the role of calcium in exocytosis and cell cycle activation in the mouse egg.
1992,
Pubmed
Knowles,
Molecular control of the oocyte to embryo transition.
2003,
Pubmed
Laurincík,
A detailed analysis of pronucleus development in bovine zygotes in vitro: cell-cycle chronology and ultrastructure.
1998,
Pubmed
Mandel,
Targeting SKP1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease.
2012,
Pubmed
Marangos,
Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1).
2007,
Pubmed
Margottin-Goguet,
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.
2003,
Pubmed
,
Xenbase
Mendez,
Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction.
2002,
Pubmed
,
Xenbase
Minami,
Zygotic gene activation and maternal factors in mammals.
2007,
Pubmed
Morimoto,
Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability.
2003,
Pubmed
Moshe,
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.
2004,
Pubmed
,
Xenbase
Muzzopappa,
Multiple roles of the F-box protein Slimb in Drosophila egg chamber development.
2005,
Pubmed
Noureddine,
Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase.
2002,
Pubmed
Ohta,
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
1999,
Pubmed
Peel,
The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.
2012,
Pubmed
Petroski,
Function and regulation of cullin-RING ubiquitin ligases.
2005,
Pubmed
Piva,
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
2002,
Pubmed
Rauh,
Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation.
2005,
Pubmed
,
Xenbase
Sako,
Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C.
2014,
Pubmed
,
Xenbase
Sánchez,
Molecular control of oogenesis.
2012,
Pubmed
Sasagawa,
Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis.
2003,
Pubmed
Schmidt,
Cytostatic factor: an activity that puts the cell cycle on hold.
2006,
Pubmed
,
Xenbase
Setoyama,
Mechanism of degradation of CPEB during Xenopus oocyte maturation.
2007,
Pubmed
,
Xenbase
Shimuta,
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition.
2002,
Pubmed
,
Xenbase
Solc,
CDC25A phosphatase controls meiosis I progression in mouse oocytes.
2008,
Pubmed
Spike,
The TRIM-NHL protein LIN-41 and the OMA RNA-binding proteins antagonistically control the prophase-to-metaphase transition and growth of Caenorhabditis elegans oocytes.
2014,
Pubmed
Spike,
Multiple Mechanisms Inactivate the LIN-41 RNA-Binding Protein To Ensure a Robust Oocyte-to-Embryo Transition in Caenorhabditis elegans.
2018,
Pubmed
Sun,
Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.
2020,
Pubmed
Sun,
Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development.
2014,
Pubmed
,
Xenbase
Swain,
ART failure: oocyte contributions to unsuccessful fertilization.
2008,
Pubmed
Toralova,
The neglected part of early embryonic development: maternal protein degradation.
2020,
Pubmed
Tsunematsu,
Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
2006,
Pubmed
Tung,
A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.
2005,
Pubmed
,
Xenbase
Wang,
Proteome of mouse oocytes at different developmental stages.
2010,
Pubmed
Wang,
Cloning and characterization of a novel oocyte-specific gene encoding an F-Box protein in rainbow trout (Oncorhynchus mykiss).
2013,
Pubmed
Wang,
Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E.
1999,
Pubmed
Watanabe,
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.
2005,
Pubmed
Welcker,
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
2008,
Pubmed
Yang,
The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition.
2017,
Pubmed
Ying,
Transcriptome profiles of pre-pubertal and adult in vitro matured ovine oocytes obtained from FSH-stimulated animals.
2021,
Pubmed
Zeng,
New insights into the roles of CUL1 in mouse placenta development.
2021,
Pubmed
Zhang,
New insights into the function of Cullin 3 in trophoblast invasion and migration.
2015,
Pubmed
Zhao,
FBXO34 Regulates the G2/M Transition and Anaphase Entry in Meiotic Oocytes.
2021,
Pubmed
Zhao,
PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition.
2020,
Pubmed
Zheng,
Ubiquitin Ligases: Structure, Function, and Regulation.
2017,
Pubmed
