Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-58936
Methods Mol Biol 2022 Jan 01;2444:105-123. doi: 10.1007/978-1-0716-2063-2_7.
Show Gene links Show Anatomy links

Approaches to Monitor Termination of DNA Replication Using Xenopus Egg Extracts.

Kavlashvili T , Dewar JM .


???displayArticle.abstract???
DNA replication is crucial for cell viability and genome integrity. Despite its crucial role in genome duplication, the final stage of DNA replication, which is termed termination, is relatively unexplored. Our knowledge of termination is limited by cellular approaches to study DNA replication, which cannot readily detect termination. In contrast, the Xenopus laevis egg extract system allows for all of DNA replication to be readily detected. Here we describe the use of this system and assays to monitor replication termination.

???displayArticle.pubmedLink??? 35290634
???displayArticle.link??? Methods Mol Biol
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis

References [+] :
Arias, Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. 2005, Pubmed, Xenbase