Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
The nuclear environment changes dramatically over the course of early development. Histones are core chromatin components that play critical roles in regulating gene expression and nuclear architecture. Additionally, the embryos of many species, including Drosophila, Zebrafish, and Xenopus use the availability of maternally deposited histones to time critical early embryonic events including cell cycle slowing and zygotic genome activation. Here, we review recent insights into how histones control early development. We first discuss the regulation of chromatin functions through interaction of histones and transcription factors, incorporation of variant histones, and histone post-translational modifications. We also highlight emerging roles for histones as developmental regulators independent of chromatin association.
Akdogan-Ozdilek,
Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag.
2022, Pubmed
Akdogan-Ozdilek,
Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag.
2022,
Pubmed
Almouzni,
Constraints on transcriptional activator function contribute to transcriptional quiescence during early Xenopus embryogenesis.
1995,
Pubmed
,
Xenbase
Almouzni,
Replication-coupled chromatin assembly is required for the repression of basal transcription in vivo.
1993,
Pubmed
,
Xenbase
Amodeo,
Histone titration against the genome sets the DNA-to-cytoplasm threshold for the Xenopus midblastula transition.
2015,
Pubmed
,
Xenbase
Attar,
The histone H3-H4 tetramer is a copper reductase enzyme.
2020,
Pubmed
,
Xenbase
Bannister,
Regulation of chromatin by histone modifications.
2011,
Pubmed
Blythe,
Coordinating Cell Cycle Remodeling with Transcriptional Activation at the Drosophila MBT.
2015,
Pubmed
Chan,
Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation.
2019,
Pubmed
Chari,
Histone concentration regulates the cell cycle and transcription in early development.
2019,
Pubmed
Cheung,
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation.
2021,
Pubmed
Cutter,
A brief review of nucleosome structure.
2015,
Pubmed
Dimitrov,
Chromatin transitions during early Xenopus embryogenesis: changes in histone H4 acetylation and in linker histone type.
1993,
Pubmed
,
Xenbase
Dorighi,
Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.
2017,
Pubmed
Ferrari,
Intestinal differentiation involves cleavage of histone H3 N-terminal tails by multiple proteases.
2021,
Pubmed
Günesdogan,
A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes.
2010,
Pubmed
Hainer,
Profiling of Pluripotency Factors in Single Cells and Early Embryos.
2019,
Pubmed
HIRSCH,
Bactericidal action of histone.
1958,
Pubmed
Hödl,
Transcription in the absence of histone H3.3.
2009,
Pubmed
Johnson,
Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos.
2018,
Pubmed
Joseph,
Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos.
2017,
Pubmed
Kaya-Okur,
CUT&Tag for efficient epigenomic profiling of small samples and single cells.
2019,
Pubmed
Khorasanizadeh,
The nucleosome: from genomic organization to genomic regulation.
2004,
Pubmed
Kornberg,
Primary Role of the Nucleosome.
2020,
Pubmed
Li,
Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition.
2014,
Pubmed
Lindeman,
Prepatterning of developmental gene expression by modified histones before zygotic genome activation.
2011,
Pubmed
Loppin,
Histone Variants: The Nexus of Developmental Decisions and Epigenetic Memory.
2020,
Pubmed
Luger,
Crystal structure of the nucleosome core particle at 2.8 A resolution.
1997,
Pubmed
Miller,
ANTIBACTERIAL PROPERTIES OF PROTAMINE AND HISTONE.
1942,
Pubmed
Müller,
Expression of a linker histone-like gene in the primordial germ cells in zebrafish.
2002,
Pubmed
Murphy,
Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming.
2018,
Pubmed
Pálfy,
Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation.
2020,
Pubmed
Pérez-Montero,
The embryonic linker histone H1 variant of Drosophila, dBigH1, regulates zygotic genome activation.
2013,
Pubmed
Prioleau,
Competition between chromatin and transcription complex assembly regulates gene expression during early development.
1994,
Pubmed
,
Xenbase
Rickels,
Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.
2017,
Pubmed
Saeki,
Linker histone variants control chromatin dynamics during early embryogenesis.
2005,
Pubmed
,
Xenbase
Sakai,
Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.
2009,
Pubmed
Santos-Rosa,
Histone H3 tail clipping regulates gene expression.
2009,
Pubmed
Sato,
Live-cell imaging probes to track chromatin modification dynamics.
2021,
Pubmed
Sato,
Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis.
2019,
Pubmed
Schulz,
Mechanisms regulating zygotic genome activation.
2019,
Pubmed
Seller,
Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila.
2019,
Pubmed
Shimada,
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.
2008,
Pubmed
Shindo,
Dynamics of Free and Chromatin-Bound Histone H3 during Early Embryogenesis.
2019,
Pubmed
Shindo,
Excess histone H3 is a competitive Chk1 inhibitor that controls cell-cycle remodeling in the early Drosophila embryo.
2021,
Pubmed
Shindo,
Modeling the role for nuclear import dynamics in the early embryonic cell cycle.
2021,
Pubmed
Sitbon,
Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway.
2020,
Pubmed
,
Xenbase
Skene,
An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites.
2017,
Pubmed
Smith,
Expression of a histone H1-like protein is restricted to early Xenopus development.
1988,
Pubmed
,
Xenbase
Strong,
Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio.
2020,
Pubmed
Syed,
The nuclear to cytoplasmic ratio directly regulates zygotic transcription in Drosophila through multiple modalities.
2021,
Pubmed
Szenker,
A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus.
2012,
Pubmed
,
Xenbase
Talbert,
Histone variants on the move: substrates for chromatin dynamics.
2017,
Pubmed
Talbert,
Histone variants at a glance.
2021,
Pubmed
van der Weide,
Developing landscapes: genome architecture during early embryogenesis.
2019,
Pubmed
Vastenhouw,
Chromatin signature of embryonic pluripotency is established during genome activation.
2010,
Pubmed
Vastenhouw,
The maternal-to-zygotic transition revisited.
2019,
Pubmed
Veil,
Pou5f3, SoxB1, and Nanog remodel chromatin on high nucleosome affinity regions at zygotic genome activation.
2019,
Pubmed
Vossaert,
Identification of histone H3 clipping activity in human embryonic stem cells.
2014,
Pubmed
Weber,
Histone variants: dynamic punctuation in transcription.
2014,
Pubmed
Wibrand,
Linker histone H1M transcripts mark the developing germ line in zebrafish.
2002,
Pubmed
Woodland,
The synthesis and storage of histones during the oogenesis of Xenopus laevis.
1977,
Pubmed
,
Xenbase
Yuan,
TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos.
2016,
Pubmed
Yuan,
Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.
2016,
Pubmed
Yue,
Oocyte-specific H2A variant H2af1o is required for cell synchrony before midblastula transition in early zebrafish embryos.
2013,
Pubmed
Zhang,
Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells.
2020,
Pubmed
