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Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna.
Shindyapina AV
,
Cho Y
,
Kaya A
,
Tyshkovskiy A
,
Castro JP
,
Deik A
,
Gordevicius J
,
Poganik JR
,
Clish CB
,
Horvath S
,
Peshkin L
,
Gladyshev VN
.
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Development is tightly connected to aging, but whether pharmacologically targeting development can extend life remains unknown. Here, we subjected genetically diverse UMHET3 mice to rapamycin for the first 45 days of life. The mice grew slower and remained smaller than controls for their entire lives. Their reproductive age was delayed without affecting offspring numbers. The treatment was sufficient to extend the median life span by 10%, with the strongest effect in males, and helped to preserve health as measured by frailty index scores, gait speed, and glucose and insulin tolerance tests. Mechanistically, the liver transcriptome and epigenome of treated mice were younger at the completion of treatment. Analogous to mice, rapamycin exposure during development robustly extended the life span of Daphnia magna and reduced its body size. Overall, the results demonstrate that short-term rapamycin treatment during development is a novel longevity intervention that acts by slowing down development and aging, suggesting that aging may be targeted already early in life.
Arneson,
A mammalian methylation array for profiling methylation levels at conserved sequences.
2022, Pubmed
Arneson,
A mammalian methylation array for profiling methylation levels at conserved sequences.
2022,
Pubmed
Bazopoulou,
Developmental ROS individualizes organismal stress resistance and lifespan.
2019,
Pubmed
Bitto,
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
2016,
Pubmed
Brown-Borg,
Dwarf mice and the ageing process.
1996,
Pubmed
Cho,
Intelligent high-throughput intervention testing platform in Daphnia.
2022,
Pubmed
Choo,
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.
2008,
Pubmed
Clancy,
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
2001,
Pubmed
Coschigano,
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.
2003,
Pubmed
Cox,
Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling.
2018,
Pubmed
Dobin,
STAR: ultrafast universal RNA-seq aligner.
2013,
Pubmed
Fang,
Effects of rapamycin on growth hormone receptor knockout mice.
2018,
Pubmed
Flurkey,
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production.
2001,
Pubmed
Fornasiero,
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.
2018,
Pubmed
Fushan,
Gene expression defines natural changes in mammalian lifespan.
2015,
Pubmed
Guevara-Aguirre,
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
2011,
Pubmed
Harrison,
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
2009,
Pubmed
He,
Shorter men live longer: association of height with longevity and FOXO3 genotype in American men of Japanese ancestry.
2014,
Pubmed
Houde,
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue.
2010,
Pubmed
Junnila,
Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females.
2016,
Pubmed
Kenyon,
A C. elegans mutant that lives twice as long as wild type.
1993,
Pubmed
Kunugi,
Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans.
2019,
Pubmed
Kwon,
Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1.
2016,
Pubmed
Lipman,
Is late-life caloric restriction beneficial?
1995,
Pubmed
Lu,
A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.
2021,
Pubmed
Ma,
Molecular signatures of longevity: Insights from cross-species comparative studies.
2017,
Pubmed
Martinez-Miguel,
Increased fidelity of protein synthesis extends lifespan.
2021,
Pubmed
McCarthy,
Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation.
2012,
Pubmed
Miller,
Differential longevity in mouse stocks selected for early life growth trajectory.
2000,
Pubmed
Miller,
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
2014,
Pubmed
Mozhui,
Genetic loci and metabolic states associated with murine epigenetic aging.
2022,
Pubmed
Panici,
Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice.
2010,
Pubmed
Rockwood,
A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice.
2017,
Pubmed
Roux,
Signaling Pathways Involved in the Regulation of mRNA Translation.
2018,
Pubmed
Samaras,
Shorter height is related to lower cardiovascular disease risk - a narrative review.
2013,
Pubmed
Schultz,
Age and life expectancy clocks based on machine learning analysis of mouse frailty.
2020,
Pubmed
Selman,
Ageing: it's a dog's life.
2013,
Pubmed
Siegmund,
Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.
2017,
Pubmed
Sun,
Longevity is impacted by growth hormone action during early postnatal period.
2017,
Pubmed
Sun,
Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth.
2022,
Pubmed
Sun,
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.
2013,
Pubmed
Sun,
Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age.
2009,
Pubmed
Tatar,
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
2001,
Pubmed
Toyama,
Identification of long-lived proteins reveals exceptional stability of essential cellular structures.
2013,
Pubmed
Tyshkovskiy,
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.
2019,
Pubmed
Williams,
Life histories of myeloproliferative neoplasms inferred from phylogenies.
2022,
Pubmed
Yang,
Longevity extension of worker honey bees (Apis mellifera) by royal jelly: optimal dose and active ingredient.
2017,
Pubmed
Yu,
clusterProfiler: an R package for comparing biological themes among gene clusters.
2012,
Pubmed
